Metabolic Effects of Polyunsaturated Fatty Acids in Chickens: A Review
محورهای موضوعی : Camelب. نوبدشاد 1 , م. رویان 2 , ع. اخلاقی 3
1 - Department of Animal Science, University of Mohaghegh Ardabili, Ardabil, Iran
2 - Department of Genomics and Animal, Agricultural Biotechnology Research Institute (ABRI), Rasht, Iran
3 - Department of Animal Science, Faculty of Agriculture, Shiraz University, Shiraz, Iran
کلید واژه: chicken, Gene expression, metabolism, polyunsaturated fatty acids,
چکیده مقاله :
Chicken has been used as a suitable model for lipid metabolism studies, because dietary modifications especially dietary fat type can change chicken body composition. Fats act as a condense source of energy and certain fatty acids such as polyunsaturated fatty acids (PUFAs) are required for both animal and human health. The n-3 PUFAs, especially, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) are well known for their favourable effects on human health. The n-3 PUFAs act as feed originated modulators of fatty acid oxidation and are feedback inhibitors of new fatty acid synthesis. This regulatory mechanism not only decreases overall liver lipid content and VLDL secretion, but also removes excessive very long-chain PUFA from cell membranes that may cause oxidant stress or damage membrane integrity. This paper reviews in brief the most important metabolic effects of PUFA in chickens.
مرغ به عنوان مدلی مناسب برای مطالعات متابولیسم لیپید مورد استفاده قرار گرفته است، زیرا تغییرات جیره‌ای به ویژه نوع چربی جیره می‌توانند ترکیب بدن مرغ را تغییر دهند. چربی‌ها به عنوان منبعی از انرژی و برخی اسیدهای چرب نظیر اسیدهای چرب با چند پیوند دوگانه (PUFAs) مورد نیاز حیوان و انسان عمل مینمایند. اسیدهای چرب با چند پیوند دوگانه از نوع n-3، به خصوص اسید آیکوزاپنتوانوئیک (EPA) و اسید دوکوزاهگزاانوئیک (DHA) اثرات مطلوب شناخته شدهای بر سلامت انسان دارند. اسیدهای چرب با چند پیوند دوگانه از نوع n-3 به عنوان محرک‌های با منشاء غذایی اکسیداسیون اسید چرب عمل نموده و مهار کننده برگشتی سنتز اسیدهای چرب جدید هستند. این سازوکارهای تنظیمی نه تنها میزان لیپید کبد و ترشح لیپوپروتئین با چگالی خیلی پایین (VLDL) را کاهش میدهند، بلکه مقادیر اضافه اسیدهای چرب بلند زنجیر با چند پیوند دوگانه را که ممکن است منجر به تنش اکسیداسیونی یا آسیب رساندن با یکپارچگی غشاء شوند را از غشاء سلولی حذف مینمایند. این مقاله به اختصار به مهمترین اثرات متابولیکی اسیدهای چرب با چند پیوند دوگانه در مرغ میپردازد.
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