Effect of ellagic acid on oxidative stress duo to brain ischemia/hypoperfusion in male rat
الموضوعات : مجله گیاهان دارویی
مریم رفیعی راد
1
,
خدیجه قاسم زاده دهکردی
2
1 - گروه زیست شناسی دانشگاه ازاد اسلامی واحد ایذه، خوزستان
2 - گروه زیست شناسی، دانشگاه آزاد اسلامی واحد سنندج
الکلمات المفتاحية: Malondialdehyde, Oxidative stress, thiol, ellagic acid, Brain Ischemia,
ملخص المقالة :
Background & Aim: Free radicals are produced in ischemic processes. Nerve damage caused by free radicals may play a role in neurological diseases and antioxidants are protective activity. Ellagic acid is a polyphenol compound with antioxidant properties which is found in fruits like pomegranate, blackberry, and all types of mulberry. This study aimed to evaluate the effect of 14 days of oral administration of ellagic acid (50 mg/kg) on brain oxidative stress indices after permanent bilateral common carotid artery occlusion or ischemia/hypoperfusion in male adult rats. Experimental: A number of 30 rats were divided into test and control groups. To make animal model of permanent cerebral hypo perfusion/ischemia, carotid arteries were ligatured as upper and lower and cut bilaterally. Rat brain tissue was extracted to separate hippocampus and measure malondialdehyde, and thiol (-Sh) groups. Results & Discussion: Our results indicated that malondialdehyde and thiol in ischemia group has significantly increased (p < 0.001) than to control group. In addition, the rate of malondialdehyde and thiol in ischemia group receiving the ellagic acid has significantly decreased (p < 0.001), than to ischemia group. Recommended applications/industries: Ellagic acid possibly with powerful antioxidant properties, can improve the effect of ischemia such as production of free radicals.
Accardo-Palumbo, A., D'Amelio, L., Pileri, D., D'Arpa, N., Mogavero, R., Amato, G., Cataldo, V., Napoli, B., Ciccia, F., Lombardo, C. and Conte, F., 2010. Reduction of plasma granzyme A correlates with severity of sepsis in burn patients. Journal of the International Society for Burn Injuries., 36: 811-818.
Acikgoz, O., Gonenc, S., Kayatekin, B. M., Uysal, N., Pekcetin, C. Semin, I. and Gure, A., 1998. Methamphetamine causes lipid peroxidation and an increase in superoxide dismutase activity in the rat striatum. Brain Research., 813: 200-202.
Allahbakhshi, E., Rafieirad, M. and Zangeneh Nezhad, Z., 2014. Neuroprotective effects of oral ellagic acid on locomotor activity and anxiety-induced by ischemia/hypoperfusion in rat., Advances in Environmental Biology., 8: 83-88.
Ascacio-Valdes J.A., Aguilera-Carbo, A., Martínez-Hernandez, J.J., Rodríguez-Herrera, R. and CN, A. 2010. Euphorbia antisyphilitica residues as a new source of ellagic acid. Chemical Papers., 64: 528- 532.
Balu, M., Sangeetha, P., Murali, G. and Panneerselvam, C., 2005. Age-related oxidative protein damages in central nervous system of rats: modulatory role of grape seed extract. International Journal of Developmental Neuroscience., 23: 501-507.
Balu, M., Sangeetha, P., Murali, G. and Panneerselvam, C., 2005. Age-related oxidative protein damages in central nervous system of rats: modulatory role of grape seed extract. International Journal of Developmental Neuroscience., 23: 501-507.
Bouayed, J., Desor, F. and Soulimani, R., 2009. Subacute oral exposure to benzo [alpha] pyrene (B[alpha]P) increases aggressiveness and affects consummatory aspects of sexual behavior in male mice. Journal of Hazardous Materials., 169: 581-585.
Bouayed, J., Rammal, H. and Soulimani, R. 2009b. Oxidative stress and anxiety: relationship and cellular pathways. Oxidative Medicine and Cellular Longevity., 2: 63-67.
Casanova, E., Garcia-Mina, J. M. and Calvo, M. I., 2008. Antioxidant and antifungal activity of Verbena officinalis L. leaves. Plant Foods for Human Nutrition., 63: 93-97.
Chao, P. C., Hsu C. C. and Yin, M. C., 2009. Anti-inflammatory and anti-coagulatory activities of caffeic acid and ellagic acid in cardiac tissue of diabetic mice. Nutrition & Metabolism (Lond)., 6: 33.
Eaton, P., Jones, M. E., McGregor, E., Dunn, M. J., Leeds, N., Byers, H. L., Leung, K. Y., Ward, M. A., Pratt J. R. and Shattock, M. J., 2003. Reversible cysteine-targeted oxidation of proteins during renal oxidative stress. Journal of the American Society of Nephrology., 14: S290-296.
Eichenbaum, H., 2004. Hippocampus: cognitive processes and neural representations that underlie declarative memory. Neuron., 44: 109-120.
Farkas, E., Luiten P. G. and Bari, F., 2007. Permanent, bilateral common carotid artery occlusion in the rat: a model for chronic cerebral hypoperfusion-related neurodegenerative diseases. Brain Research Reviwe., 54: 162-180.
Gil, M. I., Tomas-Barberan, F. A., Hess-Pierce, B., Holcroft, D. M. and Kader, A. A., 2000. Antioxidant activity of pomegranate juice and its relationship with phenolic composition and processing. Journal of Agricultural and Food Chemistry., 48: 4581-4589.
Girish, C., Raj, V., Arya, J. and Balakrishnan, S., 2013. Involvement of the GABAergic system in the anxiolytic-like effect of the flavonoid ellagic acid in mice. European Journal of Pharmacology., 710: 49-58.
Hazelton, J. L., Balan, I., Elmer, G. I., Kristian, T., Rosenthal, R. E., Krause, G., Sanderson, T. H. and Fiskum, G., 2010. Hyperoxic reperfusion after global cerebral ischemia promotes inflammation and long-term hippocampal neuronal death. Journal Neurotrauma., 27: 753-762.
Huetz, P., Mavaddat, N. and Mavri, J., 2005. Reaction between ellagic acid and an ultimate carcinogen. Journal of Chemical Information Modeling., 45: 1564-1570.
Ito, H., Miyake, M., Nishitani, E., Mori, K., Hatano, T., Okuda, T., Konoshima, T., Takasaki, M., Kozuka, M. Mukainaka, T. Tokuda, H. Nishino, H. and Yoshida, T., 1999. Anti-tumor promoting activity of polyphenols from Cowania mexicana and Coleogyne ramosissima. Cancer Letterer., 143: 5-13.
Lu, S. C. 2000. Regulation of glutathione synthesis. Current Topics in Cellular Regulation., 36: 95-116.
Mansouri, M. T., Farbood, Y., Sameri, A. Sarkaki, M. J. Naghizadeh, B. and Rafeirad, M., 2013. Neuroprotective effects of oral gallic acid against oxidative stress induced by 6-hydroxydopamine in rats. Food Chemistry., 138: 1028-1033.
Motamedi, F., Rafiei Rad, M., Sarkaki, A., Hoseini, E. and Farbood, Y., 2011. The Effect of Grape seed extract on lipid peroxidation duo to ischemia/hypoperfusion in male rat striatum. Journal of Animal Biology., 3: 37-44.
Motamedi, H., Darabpour, E., Gholipour, M. and Seyyed Nejad, S. M., 2010. In vitro assay for the anti-Brucella activity of medicinal plants against tetracycline-resistant Brucella melitensis. Journal of Zhejiang University Science B., 1: 506-511.
Puyal, J., Ginet, V. and Clarke, P. G. 2013. Multiple interacting cell death mechanisms in the mediation of excitotoxicity and ischemic brain damage: a challenge for neuroprotection. Progress in Neurobiology., 105: 24-48.
Rafiei Rad, M., Sarkaki, A., Hoseini, E., Farbood, Y. and Mansouri, S.M.T., 2011: The effect of grape seed extract on lipid peroxidation duo to ischemia/hypoperfusion in male rat striatum. Journal of Animal Biology., 3: 37-44.
Rafieirad, M., Zangeneh Nezhad, Z. and Allahbakhshi, E., 2014a. Neuroprotective effects of oral ellagic acid on locomotor activity and anxiety-induced by ischemia/hypoperfusion in rat. Advances in Environmental Biology., 8: 83-88.
Rafieirad, M., Zangeneh Nezhad, Z. and Eydipour, Z., 2014b. Effects of oral Ferulago angulata hydroalcoholic extract on lipid peroxidation induced by ischemia/hypoperfusin in the hippocampus rat. International Journal of Biology, Pharmacy and Allied Sciences, 3, 157-164.
Rammal, H., Bouayed J. and Soulimani, R. 2007. A direct relationship between aggressive behavior in the resident/intruder test and cell oxidative status in adult male mice. European Journal of Pharmacology., 627: 173-176.
Sarkaki, A., Rezaiei, M., Gharib Naseri, M. and Rafieirad, M., 2013. Improving active and passive avoidance memories deficits due to permanent cerebral ischemia by pomegranate seed extract in female rats. Malaysian Journal of Medical Sciences., 20: 25-34.
Sopala, M. and Danysz, W., 2001. Chronic cerebral hypoperfusion in the rat enhances age-related deficits in spatial memory. Journal of Neural Transmission., 108: 1445-1456.
Spencer, W. A., Jeyabalan, J., Kichambre, S. and Gupta, R. C., 2011. Oxidatively generated DNA damage after Cu (II) catalysis of dopamine and related catecholamine neurotransmitters and neurotoxins: Role of reactive oxygen species. Free Radical Biology and Medicine., 50: 139-147.
Uzar, E., Alp, H., Cevik, M. U., Firat, U., Evliyaoglu, O., Tufek, A. and Altun, Y. 2012. Ellagic acid attenuates oxidative stress on brain and sciatic nerve and improves histopathology of brain in streptozotocin-induced diabetic rats. Neurol Science., 33: 567-574.
