Ameliorative potentials of Aju Mbaise extract (AME) on Dutasteride induced oxidative stress and hepatic injury in rats
الموضوعات : مجله گیاهان دارویی
Robert Uroko
1
,
Elisha Ogwo
2
,
Paul Nweje-Anyalowu
3
,
Ikenna Obiwuru
4
,
Chinomso Aaron
5
,
Obinna Mba
6
1 - Department of Biochemistry, College of Natural Sciences, Michael Okpara University of Agriculture, Umudike, Abia State, Nigeria;
2 - Department of Human Physiology, College of Medicine and Health Sciences, Abia State University, Uturu, Nigeria;
3 - Department of Biochemistry, Faculty of Science, Clifford University, Owerrinta, Abia State, Nigeria;
4 - Department of Biochemistry, Faculty of Biological and Physical Sciences, Abia State University, Uturu, Nigeria;
5 - Department of Biochemistry, Faculty of Biological and Physical Sciences, Abia State University, Uturu, Nigeria;
6 - Department of Biochemistry, College of Natural Sciences, Michael Okpara University of Agriculture, Umudike, Abia State, Nigeria;
الکلمات المفتاحية: Oxidative stress, antioxidants, Aju Mbaise, Dutasteride, Hepatic injury, Liver markers,
ملخص المقالة :
Background & Aim: Aju Mbaiseis a polyherbal extract with nutraceuticalproperties that helps to replenish the volume of blood lost during childbirth and improves breast milk secretion and the general wellbeing of the mother. This study evaluated the ameliorative potentials of Aju Mbaise extract (AME) on Dutasteride-induced oxidative stress and hepatic injury in rats. Twenty-one rats were used to assess the acute toxicity of AME.Experimental: The study for the hepatoprotective effects of AME had five groups of rats, including normal control, Dutasteride only, AME only, Dutasteride + AME (500 mg/kg) and Dutasteride+ AME (1000 mg/kg).Results: The acute toxicity result showed that AME is relatively safe for consumption. Dutasteride caused significant elevation of liver marker enzymes, including aspartate transaminase (AST), alanine transaminase (ALT), transaminase (AST), alkaline phosphatase (ALP), total bilirubin, malondialdehyde (MDA) and significantly reduced catalase, superoxide dismutase (SOD), glutathione peroxidase (GPx), reduced glutathione (GSH), total proteins, albumin, and globulin levels in the rats received only Dutasteride. In contrast, Dutasteride induced rats treated with AME showed a significant decline in the AST, ALT, ALP, MDA, and bilirubin and significantly increased SOD, GSH, GPx, total proteins, albumin, and globulin levels compared to Dutasteride induced untreated rats. The AME-treated rats showed normal liver histo-architecture, unlike the Dutasteride-induced untreated rats that showed mild to moderate vacuolar degeneration of the hepatocytes.Recommended applications/industries: The findings show that AME ameliorates Dutasteride caused rats oxidative stress and hepatic injury.
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