Synthesis of New Glycine Cephalexin Condensed Polymer as Peptide Biopolymer for Controlled Release of Cephalexin

الموضوعات :

Aseel K.Al-Saffar ¹ , Ahamed M. Abbas ² , Dawood Salman ³

1 - College of Pharmacy, Al-Mustansiriyah University, Baghdad, Iraq
2 - Department of Chemistry, College of Science, University of Misan, Maysan, Iraq
3 - Department of Chemistry, College of Science, University of Misan, Maysan, Iraq

تاريخ الإرسال : 13 الثلاثاء , شوال, 1442 تاريخ التأكيد : 12 الجمعة , محرم, 1443 تاريخ الإصدار : 24 الأربعاء , محرم, 1443

الکلمات المفتاحية: Characterization, glycine, Physical properties, Cephalexin, biopolymer,

ملخص المقالة :

A new peptide-based polymer was synthesized via polymerization of cephalexin acid chloride with glycine acid chloride with molar ratio 1:1 in condensed polymer solution. This Glycine Cephalexin peptide biopolymer was characterized by different analyses of UV, FT-IR and 1H NMR spectroscopy. Also, physical properties of new synthesized Glycine Cephalexin peptide biopolymer were studied with measurement of its intrinsic viscosity at 30°C, swelling percentage in water and studying drug release in pH 4-10 at 37°C.

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