Effect of Aqua Training on Cortisol and Plasma Insulin in Patients with Panic Disorder
الموضوعات : Report of Health Care
Shiva Olamazadeh
1
(Department of Sport Physiology, Science and Research Branch, Islamic Azad University, Tehran, Iran)
Khosro Ebrahim
2
(Department of Sport Physiology, Science and Research Branch, Islamic Azad University, Tehran, Iran)
Farshad Ghazalian
3
(Department of Sport Physiology, Science and Research Branch, Islamic Azad University, Tehran, Iran)
Majid Barekatain
4
(Department of Neurology, Isfahan University of Medical Sciences, Isfahan, Iran)
الکلمات المفتاحية: Cortisol, Training, Insulin, Panic Disorder,
ملخص المقالة :
Introduction: Cortisol is reported to be a factor for the hypothalamic–pituitary–adrenal axis (HPA axis) in patients affected by panic disorders. On the other hand, HPA disorders can increase insulin resistance. The effect of intense aerobic exercise on the cortisol levels has also been reported on the patients with mental disorders. However, no study has yet investigated the effects of exercises in water on the cortisol and blood insulin levels in the patients affected by panic disorder. Hence, the purpose of this article was to review the effects of aqua training on cortisol and insulin levels of patients with panic disorder. Methods: Thirty six women affected by panic disorder with the average (age 38.6 ± 6.45 years and weight 70.64 ± 11.04 kg) were randomly divided in two groups of aqua training group (n=18) and the control group (n=18).The aqua training group participated in a 12-week program for water exercises (three sessions a week, each session lasting one hour, and with the intensity of 50- 85 % of maximum heart rate) and the control group continued their normal life. Pretest and posttest blood samples were taken for measuring the cortisol and blood insulin levels. Data were statistically analyzed by independent and paired sample t tests (p≤0.05). Results: The results showed that aqua training has significant effect on reduction of insulin of patients with panic disorder (p=0.001), nevertheless it has no significant effect on cortisol of patients with panic disorder (p=0.52). Conclusion: It appears that aqua training could improve the insulin levels of patients with panic disorder.
1. Skapinakis P, Lewis G, Davies S, Brugha T, Prince M, Singleton N. Panic disorder and subthreshold panic in the UK general population: epidemiology, comorbidity and functional limitation. Eur Psy. 2011; 26 (6): 354- 362.
2. Grant BF, Hasin DS, Stinson FS, Dawson DA, Goldstein RB, Smith S, et al. The epidemiology of DSM-IV panic disorder and agoraphobia in the United States: results from the National Epidemiologic Survey on Alcohol and Related Conditions. J Clin Psy. 2006; 67 (3): 363- 374.
3. Kaiya H, Sugaya N, Iwasa R, Tochigi M. Characteristics of fatigue in panic disorder patients. J Psy Clin Neur. 2008; 62 (2): 234- 237.
4. Jakuszkowiak- Wojten K, Landowski J, Wiglusz MS, Cubała WJ. Cortisol as an indicator of hypothalmic-pitituary-adrenal axis dysregulation in patients with panic disorder: a literature review. Psyc Dan. 2015; 27 (1): 445- 451.
5. Nash JR, Sargent PA, Rabiner EA, Hood SD, Argyropoulos SV, Potokar JP et al. Serotonin 5-HT1A receptor binding in people with panic disorder: positron emission tomography study. Br J Psy. 2008; 193: 229- 234.
6. Siegmund A, Koster L, Meves AM, Plag J, Stoy M, et al. Stress hormones during flooding therapy and their relationship to therapy outcome in patients with panic disorder and agoraphobia. J Psy Res. 2011; 45: 339- 346.
7. Goldstein S, Halbreich U, Asnis G, Endicott J, Alvir J. The hypothalamic (pituitary) adrenal system in panic disorder. Am J Psy. 1987; 144: 1320- 1323.
8. Bandelow B, Wedekind D, Sandvoss V, Broocks A, Hajak G, Jutta P, et al. Diurnal variation of cortisol in panic disorder. Psy Res .2000; 95: 245- 250.
9. Uhde TW, Joffe RT, Jimerson DC, Post RM. Normal urinary free cortisol and plasma MHPG in panic disorder: Clinical and theoretical implications. Bio Psy.1988; 6 (23): 575- 585.
10. Bauer M, Jeckel CMM, Luz C .The role of stress factors during aging of the immune system. Ann NY Sci. 2009; 1153: 139- 152.
11. Pauli R, Souza L, Rogatto G, Gomes R, Luciano E .Glicocorticóides e síndrome metabólica: aspectos favoráveis do exercício físico nesta patofisiologia. Rev Port Cien Desp. 2006; 6: 217- 228.
12. Watts M. Endosulfan pesticide action network. Asia Pacific. 2008; 1- 41.
13. Ehlert U, Gaab J, Heinrichs M. Psychoneuroendocrinological contributions to the etiology of depression, posttraumatic stress disorder, and stress-related bodily disorders: The role of the hypothalamus- pituitary- adrenal axis. Bio Psy. 2001; 57: 141- 152.
14. Pull CB, Damsa C. Pharmacotherapy of panic disorder. Neu Dis Tre. 2008; 4 (4): 779- 795.
15. Strohle A, Graetz B, Scheel M, Wittmann A, Feller C, Heinz A, et al. The acute antipanic and anxiolytic activity of aerobic exercise in patients with panic disorder and healthy control subjects. J Psy Res. 2009; 43 (12): 1013- 1017.
16. Esquivel G, Dı´az-Galvis J, Schruers K, Berlanga C, Lara-Mun˜oz C, Griez E. Acute exercise reduces the effects of a 35 % CO2 challenge in patients with panic disorder. J Aff Dis. 2008; 107 (1-3): 217- 220.
17. Frohman AF, Okuda DT, Beh S, Treadaway K, Mooi C, Davis SL, et al. Aquatic training in MS: neurotherapeutic impact upon quality of life. Ann Clin Tra Neur. 2015; 2 (8): 864- 872.
18. Aggon E, Kiyici F, Ucan I, Colak M, Agirbas O, Hackney AC. The effect of
wrestling training and sauna practice on cortisol and insulin hormones. Adv Phys Edu. 2016; 7: 303- 310.
19. Ketabi Pour M. The effect of an aerobic exercise course on cysteine and cardiovascular risk factors on postmenopausal women. MSc Thesis. Shiraz University. 2010.
20. Iwase S, Kawahara Y, Nishimura N, Takada H, Nagata M, Niimi Y, Miwa C. Effects of dry and mist saunas on circulatory and thermoregulatory functions in humans. Hea J. 2013; 5: 267- 273.
21. Pilch W, Pokora I, Szyguła Z, Pałka T, Pilch P, Cisoń T, et al. Effect of a single finnish sauna session on white blood cell profile and cortisol levels in athletes and non- athletes. Jou Hum Kin. 2013; 39: 127- 135.
22. Staufenbiel SM, Pennix BW, Spijker AT, Elzinga BM, van Rossum EF. Hair cortisol, stress exposure, and mental health in humans: a systematic review. Psy J. 2013; 38: 1220- 1235.
23. Rhardt A, Ising M, Unschuld PG, Kern N, Lucae S, Putz B, et al. Regulation of the hypothalamic-pituitary- adrenocortical system in patients with panic disorder. Neu Psy. 2006; 31: 2515- 2522.
24. Gomes RM, Sardinha A, Soares de Arau Jo CG, Nardi AE, Deslandes AC. Aerobic training intervention in panic disorder: a case-series study. Med Xpr. 2014; 1 (4): 195- 201.
25. Broocks A, Bandelow B, Pekrun G, George A, Meyer T, Bartmann U, et al. Comparison of aerobic exercise, clomipramine, and placebo in the treatment of panic disorder. Am J Psy. 1998; 155 (5): 603- 609.
26. Wedekind D, Sprute A, Broocks A, Huther G, Engel K, Falkai P, et al. Nocturnal urinary cortisol excretion over a randomized controlled trial with paroxetine vs. placebo combined with relaxation training or aerobic exercise in panic disorder. Cur Pha Des. 2008; 14 (33): 3518- 3524.
27. Wedekind D, Broocks A, Weiss N, Engel K, Neubert K, Bandelow B. A randomized, controlled trial of aerobic exercise in combination with paroxetine in the treatment of panic disorder. Wor J Bio Psy. 2010; 11 (7): 904- 913.
28. Ratamess NA, Hoffman JR, Kraemer WJ, Ross RE, Tranchina CP, Rashti SL, Faigenbaum AD. Effects of a competitive wrestling season on body composition, endocrine markers, and anaerobic exercise performance in NCAA collegiate wrestlers. Eur J App Phys. 2013; 113: 1157- 1168.
29. Sadegh S, Golestany A. Effects of 10 weeks of aerobic training in water on chemerin and insulin resistance in women with multiple sclerosis. Hor Med Sci J. 2016; 23: 229- 234.
30. Kasprzak Z, Pilaczyńska-Szcześniak L. Effects of regular physical exercises in the water on the metabolic profile of women with abdominal obesity. J Hum Kin. 2014; 41:71- 79.
31. Roemmich JN, Sinning WE. Weight loss and wrestling training: effects on growth- related hormones. J App Phy. 1997; 82: 1760- 1764.
32. Daly W, Seegers C, Timmerman S, Hackney AC. Peak cortisol response to exhausting exercise: effects of blood sampling schedule. Med Spo. 2004; 8: 17- 20.
33. Santos JM, Ribero SB, Gaya AR, Appell HJ, Duarte JA. Skeletal muscle pathways of concentration-enhanced glucose uptake. Int J Spo Med. 2008; 29 (10): 785- 794.
34. Farese RV. Function and dysfunction of a PKC isoforms for glucose transport in insulin-sensitive and insulin resistance states. Am J Phy End Met. 2002; 283: E1- E11.
35. Fuerger PT, Bracy DP, Malabanan CM, Pencek RR, Wasermann DH. Distributed control of glucose uptake by working muscles of conscious mice: role of transport and phosphorylation. Am J Phy End Met. 2004; 286: 77- 84.
36. McGee SL, Hargreaves M. Exercise and skeletal muscle glucose transporter 4 expression: molecular mechanisms. Clin Exp Pha Phy. 2006; 33 (4): 395- 399.
37. Pauli R, Souza L, Rogatto G, Gomes R, Luciano E .Glicocorticoides e sindrome metabolica: aspectos favoraveis do exercise fisico nesta patofisiologia. Rev Port Cien Desp. 2006; 6: 217- 228.
