اثر تمرین تناوبی شدید و مصرف مکمل کندر بر سطح سایتوکاین¬های التهابی و فاکتور نوروتروفیک مشتق از مغز در بافت هیپوکامپ موش‌های پیر
الموضوعات : فصلنامه زیست شناسی جانوری
جعفر قربانی
1
,
سیدرضا عطارزاده حسینی
2
,
امیر رشید لمیر
3
,
محمد مسافری ضیاءالدینی
4
1 - گروه فیزیولوژی ورزشی، دانشکده علوم ورزشی دانشگاه فردوسی مشهد، ایران
2 - گروه فیزیولوژی ورزشی، دانشکده علوم ورزشی دانشگاه فردوسی مشهد، ایران
3 - گروه فیزیولوژی ورزشی، دانشکده علوم ورزشی دانشگاه فردوسی مشهد، ایران
4 - گروه فیزیولوژی ورزشی، دانشکده علوم ورزشی دانشگاه فردوسی مشهد، ایران
الکلمات المفتاحية: پیری, تمرین تناوبی شدید, کندر, التهاب نورونی, فاکتور نوروتروفیک,
ملخص المقالة :
امروزه از فعالیت ورزشی و مصرف گیاهان دارای خاصیت ضداکسایشی به عنوان تعدیل کننده التهاب پیری برای پیشگیری و درمان بیماریهای وابسته به التهاب نام میبرند. هدف تحقیق حاضر، بررسی اثر تمرین تناوبی شدید و مصرف مکمل کندر بر سطح سایتوکاینهای التهابی و فاکتورنوروتروفیک مشتق از مغز در بافت هیپوکامپ موش‌های پیر بود. نمونه آماری تحقیق شامل 28 سر موش صحرایی نرنژاد ویستار در چهار گروه تمرین تناوبی+ دارونما، تمرین تناوبی+ مکمل کندر، مکمل کندر و شم قرارگرفتند. تمرین تناوبی شدید روی تردمیل، پنج روز در هفته به مدت شش هفته اجرا شد. گروه‌های مکمل، طی دوره مداخله 50 میلیگرم (به ازای هر کیلوگرم وزن بدن) محلول کندر به صورت گاواژ دریافت کردند. پس از بیهوشی، کالبد شکافی انجام و سطوح TNF-α، IL-6و BDNF بافت هیپوکامپ اندازهگیری شد. نتایج نشان داد که براساس آزمون تحلیل کروسکال والیس تفاوت رتبههای بین گروهی سطوح TNF-α، IL-6 و BDNF بافت هیپوکامپ موش‌های صحرایی پیر نر به لحاظ آماری معنی دار نبود (05/0 <p ). درنتیجه به نظر میرسد تمرین تناوبی شدید و مصرف مکمل کندر نمی‌تواند تاثیر معناداری بر سطوح سایتوکاین های التهابی و فاکتور نوروتروفیک مشتق از مغز بافت هیپوکامپ ایجاد نماید.
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