تثبيت داروي دوکسوروبيسين بر بستر نانو سيستم گرافن اکسايد و مطالعه شبيه سازي رايانه اي (In-Silico) بر آنزيم توپوايزومراز II
الموضوعات : فصلنامه علمی - پژوهشی مواد نوینصدیقه پرگاله بروجني 1 , نورالدین گودرزیان 2 , ندا حسن زاده 3 , محمد کاظم محمدی 4
1 - گروه شيمي ، واحد علوم و تحقيقات خوزستان، دانشگاه آزاد اسلامي، اهواز، ايران
2 - گروه شيمي ، واحد شيراز، دانشگاه آزاد اسلامي، شيراز، ايران
3 - گروه شيمي ، واحد علوم و تحقيقات خوزستان، دانشگاه آزاد اسلامي، اهواز، ايران
4 - گروه شیمی، واحد اهواز، دانشگاه آزاد اسلامی، اهواز، ایران
الکلمات المفتاحية: دوکسوروبيسين, گرافن اکسايد, آنزيم توپوايزومراز 2, رهايش, نانو سيستم,
ملخص المقالة :
نتيجه گيري: بر طبق داده هاي طيف XRD، در GO پيک قوي مشاهده شد، که مربوط به فاصله بين لايه‌اي (d-spacing) و نشان‌دهنده ساختار لايه‌اي و وجود گروه‌هاي اکسيژن در سطح GO بود. از سوي ديگر در طيف XRD-rGO نيز شاهد پيک در حدود ۲۶-۲۷ درجه بوديم که بيانگر کاهش فاصله بين لايه‌اي (d-spacing) مي باشد که به دليل حذف گروه‌هاي اکسيژن و افزايش يکنواختي ساختار است. در الگوي پراش rGO شاهد طيفي ساده‌تر و يکنواخت‌تر بوديم که نشان‌دهنده ساختار بلوري بهبود يافته و کاهش نواقص سيستمي بود. با توجه به نتايج مطلوب داد هاي دستگاهي و مطالعه درون رايانه اي بر روي آنزيم توپوايزومراز ۲ و اهميت بالاي زيست‌سازگاري حامل‌هاي دارويي، ارجحيت داروي تثبيت شده دوکسوروبيسين بر بستر نانو سيستم گرافن اکسايد، نسبت به داروي اوليه مشهود مي باشد و ترکيبات اخير مي‌توانند به عنوان کانديداي مناسبي جهت بهبود هر چه بيشتر بيماران سرطاني و کنترل بيماري آن‌ها استفاده گردند.
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