سیانوباکتری ها منبعی غنی از داروهای ضد سرطانی
الموضوعات :
بهاره نوروزی
1
(گروه بیوتکنولوژی، دانشکده علوم و فناوری¬های همگرا، واحد علوم و تحقیقات، دانشگاه آزاد اسلامی، تهران، ایران)
الکلمات المفتاحية: سرطان, سیانوباکتری ها, ریز جلبکها, متابولیتهای ثانویه, ترکیبات بیواکتیو,
ملخص المقالة :
افزایش میزان مرگ و میر سرطان در نتیجه استفاده بیش از حد از داروهای شیمیایی، آن را به یکی از مرگبارترین بیماری ها در سراسر جهان تبدیل کرده است. به همین دلیل امروزه بیشترین تحقیقات امروزه روی محصولات دارویی طبیعی متمرکز است. در نتیجه هدف از این مقاله، مروری بر خواص ضد سرطانی سیانوباکتری ها در صنعت دارو و درمان است. برای نگارش این مقاله، هم از تجربیات و مقالات نویسندگان مقاله و هم از جدیدترین مقالات موجود در پایگاه های اطلاعاتی Web of Science، Pub Med، Google Scholar، Scopus و ScienceDirect استفاده گردیده است. فرآورده های طبیعی، منبع مهمی از ترکیب های جدید دارویی که نه تنها خود دارای ارزش دارویی هستند، بلکه به عنوان مدل های ساختمانی برای ایجاد آنالوگ های سنتتیک نیز به کار می روند. در این میان، متابولیت های دریایی ثانویه مستخرج از سیانوباکتری ها به عنوان منبع مطلوبی از ترکیبات فعال دارویی بالقوه جدید، دارای تنوع ساختاری و فعالیت های بیولوژیکی متنوع از قبیل خاصیت ضد التهاب، ضد ویروس، ضد میکروب و ویژگی¬های ضد توموری هستند. این مقاله مروری، پتانسیل ترکیبات و متابولیتهای سیانوباکتری ها را به عنوان داروهای ضد سرطان بررسی کرده و ساختار شیمیایی و مکانیسم‌های عمل آن ها را بررسی می‌کند.
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