Molecular Dynamics Simulation of Water Transportation through Aquaporin-4 in Rat Brain Cells
الموضوعات : Journal of Physical & Theoretical Chemistry
F. Kaveh
1
(-)
K. zare
2
(-)
S. Salemi
3
(-)
A. R. Illchani
4
(-)
N. Khodayari
5
(-)
الکلمات المفتاحية: Aquaporin-4, Brain edema, Molecular Dynamics, CHARMM,
ملخص المقالة :
This paper investigates the mechanism of water transportation through aquaporin-4(AQP4) of ratbrain cells by means of molecular dynamics simulation with CHARMM software. The AQP4 wasembedded into a bilayer made of Dimystroilphosphatylcholine (DMPC). The results illustrate thatwater molecules move through AQP4's channel with change of orientation of oxygen of eachwater molecule.
