بررسی متابولیت ها و اثرات دارویی گیاه دارویی Salvia rhytidea Benth.
الموضوعات :
شهرزاد فولادی
1
(بخش بیوشیمی.دانشکده علوم. دانشگاه پیام نور. واحد تهران)
الکلمات المفتاحية: دارویی, اثرات, متابولیت, گیاه دارویی,
ملخص المقالة :
گونه های مختلف جنس Salvia از خانواده نعنائیان در طب سنتی به عنوان گیاهان دارویی در مناطق متفاوتی از جهان استفاده می شوند. همین امر باعث شده که پژوهشگران به کاوش در زمینه مواد موثره این گیاهان بپردازند. یکی از گونه های این جنس گیاه Salvia rhytidea Benth.است که از گونه های بومی مناطق شرقی ایران است و در این مناطق به صورت وحشی می روید.این گیاه سابقه استفاده در طب سنتی را داشته و هم اکنون هم به عنوان محرک جریان خون, برطرف کننده لخته خون, پایین اورنده قند خون و انتی اکسیدان استفاده می شود.اخیرا محققان تحقیقاتی را در زمینه کشف متابولیت ها وخواص دارویی این گیاه انجام داده اند . تحقیقات پژوهشگران دراین زمینه تا به امروز حاکی از وجود فلاونوئیدها و تانن ها و ترکیب فنولی رزمارینیک اسید در عصاره متانولی سرشاخه های گلدار و وجود دیترپنوئیدهای متفاوت در عصاره اتری ریشه این گیاه می باشد. از عصاره متانولی سرشاخه های گلدار این گیاه خاصیت ضد قارچی به اثبات رسیده است بعلاوه از عصاره متانولی اندامهای هوایی این گونه شامل سرشاخه های گلدار و برگها و ساقه های جوان خاصیت پایین اورندگی قند خون و خاصیت مهارکنندگی انزیم الفاگلوکزیداز گزارش شده است. قابل ذکر است که خواص دارویی متعددی از جمله خاصیت ضد باکتریایی ,ضد پروتوزوایی, ضد قارچی ,ضد انگل مولد بیماری سالک ,ضد میکروارگانیزمهای مولد بیماری مالاریا و بیماری خواب ,ضد توموری ,ضد سرطانی ,مهارکنندگی انزیمی ,انتی اکسیدانی ,سیتوتوکسیک, پایین اورندگی فشار خون ,انتی کولین استرازی وافت کشی از ریشه این گیاه به اثبات رسیده است.
1) Abd-Elmageed, M.A. and B.A, Hussein. 2008. Cytotoxicity and antimicrobial activity of Salvia officinalis L. flowers. Sudan Journal of Medical Sciences. 3(2): 127-132.
2) Abou Dahab, M.A., El-Bahr, M.K., Taha, H.S., Habib, A.M., Bekheet, S.A., Gabr, A.M.M. and A, Refaat. 2007. Cytotoxic activity of Taxodium calli extracts on rat liver cells. J Appl Sci Res. 3(12): 1987-1996.
3) Akaberi, M., Mehri, S. and M, Iranshahi. 2015. Multiple pro-apoptotic targets of abietane diterpenoids from Salvia species. Fitoterapia. 100: 118-132.
4) Ansari, M., Sharififar, F., Arabzadeh, A.M., Mehni, F., Mirtadzadini, M., Iranmanesh, Z. and N, Nikpour. 2014. In vitro evaluation of anti-herpes simplex-1 activity of three standardized medicinal plants from Lamiaceae. Ancient science of life. 34(1): 33.
5) Arabi, S., Arshami, J. and A.R, Haghparast. 2014. Effects of Salvia Officinalis L. Extract on Biochemical Blood Parameters in Male Rats. J Adv Med Biomed Res. 22(94): 34-43.
6) Badiee, P., Nasirzadeh, A.R. and M, Motaffaf. 2012. Comparison of Salvia officinalis L. essential oil and antifungal agents against candida species. J. Pharm. Technol. Drug Res. 1(7).
7) Bahadori, M.B., Valizadeh, H., Asghari, B., Dinparast, L., Farimani, M.M. and S, Bahadori. 2015. Chemical composition and antimicrobial, cytotoxicity, antioxidant and enzyme inhibitory activities of Salvia spinosa L. Journal of Functional Foods. 18: 727-736.
8) Baricevic, D., Sosa, S., Della Loggia, R., Tubaro, A., Simonovska, B., Krasna, A. and A, Zupancic. 2001. Topical anti-inflammatory activity of Salvia officinalis L. leaves: the relevance of ursolic acid. Journal of ethnopharmacology. 75(2-3): 125-132.
9) Bonito, M.C., Cicala, C., Marcotullio, M.C., Maione, F. and N, Mascolo. 2011. Biological activity of bicyclic and tricyclic diterpenoids from Salvia species of immediate pharmacological and pharmaceutical interest. Natural product communications. 6(8). :1934578X1100600839.
10) Burmistrova, O., Simões, M.F., Rijo, P., Quintana, J., Bermejo, J. and F, Estevez. 2013. Antiproliferative activity of abietane diterpenoids against human tumor cells. Journal of natural products. 76(8): 1413-1423.
11) da Cruz Araújo, E.C., Lima, M.A.S., Montenegro, R.C., Nogueira, M., Costa-Lotufo, L.V., Pessoa, C., de Moraes, M.O. and E.R, Silveira. 2006. Cytotoxic abietane diterpenes from Hyptis martiusii Benth. Zeitschrift für Naturforschung C. 61(3-4): 177-183.
12) Dal Pra, V., Bisol, L.B., Detoni, S., Denti, M., Grando, J., Pollo, C., Pasquali, T.R., Hoffmann, A.E., Mazutti, M.A. and S.M, Macedo. 2011. Anti-inflammatory activity of fractionated extracts of Salvia officinalis. Journal of Applied Pharmaceutical Science. 1(7): 67.
13) de Melo, G.A.N., Fonseca, J.P., Farinha, T.O., do Pinho, R.J., Damiatilde, M.J., Grespan, R., da Silva, E.L., Bersani-Amado, C.A. and R.K.N, Cuman. 2012. Anti-inflammatory activity of Salvia officinalis L. Journal of Medicinal Plants Research. 6(35): 4934-4939.
14) Dellavalle, P.D., Cabrera, A., Alem, D., Larrañaga, P., Ferreira, F. and M, Dalla Rizza. 2011. Antifungal activity of medicinal plant extracts against phytopathogenic fungus Alternaria spp. Chilean journal of agricultural research. 71(2): 231.
15) Ebrahimi, S.N., Farimani, M.M., Mirzania, F., Soltanipoor, M.A., De Mieri, M. and M, Hamburger. 2014. Manoyloxide sesterterpenoids from Salvia mirzayanii. Journal of natural products. 77(4): 848-854.
16) Ebrahimi, S.N., Zimmermann, S., Zaugg, J., Smiesko, M., Brun, R. and M, Hamburger. 2013. Abietane diterpenoids from Salvia sahendica–antiprotozoal activity and determination of their absolute configurations. Planta medica. 29(2): 150-156.
17) Efferth, T., Kahl, S., Paulus, K., Adams, M., Rauh, R., Boechzelt, H., Hao, X., Kaina, B. and R, Bauer. 2008. Phytochemistry and pharmacogenomics of natural products derived from traditional Chinese medicine and Chinese materia medica with activity against tumor cells. Molecular Cancer Therapeutics. 7(1): 152-161.
18) Eghtesadi, F., Farimani, M.M., Hazeri, N. and J, Valizadeh. 2016. Abietane and nor-abitane diterpenoids from the roots of Salvia rhytidea. SpringerPlus. 5(1): 1-6.
19) Farimani, M.M. and Z, Mazarei. 2014. Sesterterpenoids and other constituents from Salvia lachnocalyx Hedge. Fitoterapia. 98: 234-240.
20) Farimani, M.M. and M, Miran. 2014. Labdane diterpenoids from Salvia reuterana. Phytochemistry, 108: 264-269.
21) Farimani, M.M., Moghaddam, F.M., Esmaeili, M.A. and G, Amin. 2012. A lupane triterpenoid and other constituents of Salvia eremophila. Natural product research, 26(21): 2045-2049.
22) Fiore, G., Massarelli, P., Sajeva, M. and G.G, Franchi. 2012. Anti-tumor activity of the methanolic extracts of Salvia menthifolia. Revista Brasileira de Farmacognosia. 22: 381-387.
23) Fooladi, S., Ansari, M., Sharififar, F., Pournourmohammadi, S., Rad, B.L. and N, Mohamadi. 2016. Effect of Salvia rhytidea Benth. extract on serum glucose, gut alphaglucosidase in healthy and streptozotocin-induced diabetic rats. Journal of Ayurvedic and Herbal Medicine. 2(2): 40-42.
24) Fronza, M., Murillo, R., Ślusarczyk, S., Adams, M., Hamburger, M., Heinzmann, B., Laufer, S. and I, Merfort. 2011. In vitro cytotoxic activity of abietane diterpenes from Peltodon longipes as well as Salvia miltiorrhiza and Salvia sahendica. Bioorganic & medicinal chemistry. 19(16): 4876-4881.
25) Ginda, H., Kusumi, T., Ishitsuka, M.O., Kakisawa, H., Weijie, Z., Jun, C. and G.Y, Tian. 1988. Salviolone, a cytotoxic bisnorditerpene with a benzotropolone chromophore from a chinese drug dan-shen (Salvia miltiorrhiza). Tetrahedron letters, 29(36): 4603-4606.
26) González, A.G., Aguiar, Z.E., Grillo, T.A. and J.G, Luis. 1992. Diterpenes and diterpene quinones from the roots of Salvia apiana. Phytochemistry. 31(5): 1691-1695.
27) Habibi, Z., Yousefi, M., Aghaie, H.R., Salehi, P., Masoudi, S. and A, Rustaiyan. 2008. Chemical composition of essential oil of Salvia persepolitana Boiss. and Salvia rhytidea Benth. from Iran. Journal of Essential Oil Research. 20(1): 1-3.
28) Haghjoo, R. and M, Tadjalli. 2015. The effect of the oral administration of Salvia rhytidia extract on neural cell numbers of cerebral cortex and hippocampus following ischemia-reperfusion in rat. Armaghane danesh. 20(2): 138-148.
29) Hanson, R.L., Lardy, H.A. and Kupchan, S.M., 1970. Inhibition of phosphofructokinase by quinone methide and α-methylene lactone tumor inhibitors. Science. 168(3929): 378-380.
30) Ikeshiro, Y., Hashimoto, I., Iwamoto, Y., Mase, I. and Y, Tomita. 1991. Diterpenoids from Salvia miltiorrhiza. Phytochemistry. 30(8): 2791-2792.
31) Janicsák, G., Zupkó, I., Nikolova, M.T., Forgo, P., Vasas, A., Máthé, I., Blunden, G. and J, Hohmann. 2011. Bioactivity-guided study of antiproliferative activities of Salvia extracts. Natural product communications. 6(5): 1934578X1100600501.
32) Jassbi, A.R., Eghtesadi, F., Hazeri, N., Ma’sumi, H., Valizadeh, J., Chandran, J.N., Schneider, B. and I.T, Baldwin. 2017. The roots of Salvia rhytidea: a rich source of biologically active diterpenoids. Natural product research. 31(4): 477-481.
33) Jassbi, A.R., Mehrdad, M., Eghtesadi, F., Ebrahimi, S.N. and I.T, Baldwin. 2006. Novel rearranged abietane diterpenoids from the roots of Salvia sahendica. Chemistry & biodiversity. 3(8): 916-922.
34) Jassbi, A.R., Zare, S., Firuzi, O. and J, Xiao. 2016. Bioactive phytochemicals from shoots and roots of Salvia species. Phytochemistry reviews. 15(5): 829-867.
35) Jirovetz, L., Wlcek, K., Buchbauer, G., Gochev, V., Girova, T., Stoyanova, A., Schmidt, E. and M, Geissler. 2007. Antifungal activities of essential oils of Salvia lavandulifolia, Salvia officinalis and Salvia sclarea against various pathogenic Candida species. Journal of essential Oil Bearing Plants. 10(5): 430-439.
36) Kintzios, S.E. 2000. Sage: the genus Salvia. CRC Press.
37) Klepser, T.B. and M.E, Klepser. 1999. Unsafe and potentially safe herbal therapies. American Journal of Health-System Pharmacy. 56(2): 125-138.
38) Kolak, U., Kabouche, A., Öztürk, M., Kabouche, Z., Topçu, G. and A, Ulubelen. 2009. Antioxidant diterpenoids from the roots of Salvia barrelieri. Phytochemical analysis. 20(4): 320-327.
39) Kupchan, S.M., Karim, A. and C, Marcks. 1969. Tumor inhibitors. XLVIII. Taxodione and taxodone, two novel diterpenoid quinone methide tumor inhibitors from Taxodium distichum. The Journal of organic chemistry. 34(12): 3912-3918.
40) Kusumoto, N., Ashitani, T., Hayasaka, Y., Murayama, T., Ogiyama, K. and K, Takahash. 2009. Antitermitic activities of abietane-type diterpenes from Taxodium distichum cones. Journal of chemical ecology. 35(6): 635-642.
41) Mahmoudi, E. and A, Ahmadi. 2013. Evaluation of Salvia officinalis antifungal properties on the growth and morphogenesis of Alternaria alternata under in-vitro conditions. Technical Journal of Engineering and Applied Sciences. 3(17): 2062-2069.
42) Michavila, A., Fernández-Gadea, F. and B, Rodríguez. 1985. Abietane diterpenoids from the root of Salvia lavandulaefolia. Phytochemistry. 25(1): 266-268.
43) Moghddam, F.M., Farimani, M.M., Taheri, S., Tafazoli, M. and G, Amin. 2008. Chemical constituents from Salvia macrosiphon. Chemistry of natural compounds. 44(4): 518-519.
44) Moridi Farimani, M., Nejad Ebrahimi, S., Salehi, P., Bahadori, M.B., Sonboli, A., Khavasi, H.R., Zimmermann, S., Kaiser, M. and M, Hamburger. 2013. Antitrypanosomal triterpenoid with an ε-lactone E-ring from Salvia urmiensis. Journal of natural products. 76(9): 1806-1809.
45) Mosafa, E., Yahyaabadi, S. and M, Doudi. 2014. In-vitro antibacterial properties of sage (Salvia officinalis) ethanol extract against multidrug resistant Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa and Klebsiella pneumoniae. Zahedan Journal of Research in Medical Sciences. 16(10): 42-46.
46) Moujir, L., Gutiérrez‐Navarro, A.M., San Andrés, L. and J.G, Luis. 1996. Bioactive diterpenoids isolated from Salvia mellifera. Phytotherapy Research. 10(2): 172-174.
47) Acosta, B., Pascual Villalobos, M.J. and B, Rodríguez. 2008. The antifeedant activity of natural plant products towards the larvae of Spodoptera littoralis.
48) Plants, I.M., The 23nd Iranian Seminar of Organic Chemistry.
49) Rechinger, K.H., Browicz, K., Persson, K. and P, Wendelbo. 1982. Flora Iranica, Akademische Druck-U. Verlagsanstalt, Graz. 150(2): 108-216.
50) Rustaiyan, A., Akhgar, M.R., Masoudi, S. and F, Nematollahi. 2005. Chemical Composition of Essential Oils of Three Salvia Species Growing Wild in Iran: Salvia rhytidea Benth., S. limbata CA Mey. and S. palaestina Benth. Journal of Essential Oil Research, 17(5): 522-524.
51) Saijo, H., Kofujita, H., Takahashi, K. and T, Ashitani. 2015. Antioxidant activity and mechanism of the abietane-type diterpene ferruginol. Natural product research. 29(18): 1739-1743.
52) Sajjadi, S.E. and A.L.I.R.E.Z.A, Ghannadi. 2005. Essential oil of Persian sage, Salvia rhytidea Benth. ACTA PHARMACEUTICA-ZAGREB. 55(3): 321.
53) Salari, S., Bakhshi, T., Sharififar, F., Naseri, A. and P.G.N, Almani. 2016. Evaluation of antifungal activity of standardized extract of Salvia rhytidea Benth.(Lamiaceae) against various Candida isolates. Journal de mycologie medicale. 26(4): 323-330.
54) Salimpour, F., Mazooji, A., Mazaher, F. and G, Barzin. 2014. Comparative study of antibacterial properties of four species of Salvia L. as a medicinal plant.
55) Shaheen, U.Y., Hussain, M.H. and H.A, Ammar. 2011. Cytotoxicity and antioxidant activity of new biologically active constituents from Salvia Lanigra and Salvia Splendens. Pharmacognosy Journal. 3(21): 36-48.
56) Swarup, V., Ghosh, J., Ghosh, S., Saxena, A. and A, Basu. 2007. Antiviral and anti-inflammatory effects of rosmarinic acid in an experimental murine model of Japanese encephalitis. Antimicrobial agents and chemotherapy. 51(9): 3367-3370.
57) Tan, N., Kaloga, M., Radtke, O.A., Kiderlen, A.F., Öksüz, S., Ulubelen, A. and H, Kolodziej. 2002. Abietane diterpenoids and triterpenoic acids from Salvia cilicica and their antileishmanial activities. Phytochemistry, 61(8): 881-884.
58) Topcu, G., Eriş, C. and A, Ulubelen. 1996. Rearranged abietane diterpenes from Salvia limbata. Phytochemistry. 41(4): 1143-1147.
59) Topcu, G. and A.C, Gören. 2007. Biological activity of diterpenoids isolated from Anatolian Lamiaceae plants. Records of Natural Products. 1(1): 1.
60) Topcu, G., Kolak, U., Ozturk, M., Boga, M., Damla Hatipoglu, S., Bahadori, F., Culhaoglu, B. and T, Dirmenci. 2013. Investigation of anticholinesterase activity of a series of Salvia extracts and the constituents of Salvia staminea. The Natural Products Journal. 3(1):3-9.
61) Ulubelen, A. 2003. Cardioactive and antibacterial terpenoids from some Salvia species. Phytochemistry. 64(2): 395-399.
62) Ulubelen, A., Öksüz, S., Kolak, U., Birman, H. and W, Voelter. 2000. Cardioactive terpenoids and a new rearranged diterpene from Salvia syriaca. Planta medica. 66(07): 627-629.
63) Ulubelen, A., Öksüz, S., Kolak, U., Tan, N., Bozok-Johansson, C., Çelik, C., Kohlbau, H.J. and W, Voelter. 1999. Diterpenoids from the roots of Salvia bracteata. Phytochemistry, 52(8): 1455-1459.
64) Ulubelen, A., Topçu, G., Chai, H.B. and J.M, Pezzuto. 1999. Cytotoxic activity of diterpenoids isolated from Salvia hypargeia. Pharmaceutical biology. 37(2): 148-151.
65) Ulubelen, A., Topcu, G., Tan, N., Lin, L.J. and G.A, Cordell. 1992. Microstegiol, a rearranged diterpene from Salvia microstegia. Phytochemistry. 31(7): 2419-2421.
66) Wu, Y.B., Ni, Z.Y., Shi, Q.W., Dong, M., Kiyota, H., Gu, Y.C. and B, Cong. 2012. Constituents from Salvia species and their biological activities. Chemical reviews. 112(11): 5967-6026.
67) Yang, Z., Kitano, Y., Chiba, K., Shibata, N., Kurokawa, H., Doi, Y., Arakawa, Y. and M, Tada. 2001. Synthesis of variously oxidized abietane diterpenes and their antibacterial activities against MRSA and VRE. Bioorganic & medicinal chemistry. 9(2): 347-356.
68) Yong, Z.J.H. 1995. Two new diterpenoids, prtoketolactone and neoprionitone, from Salvia prionitis. Nat Prod Res Develop. 4(1).
69) Zaghloul, A.M., Gohar, A.A., Naiem, Z.A.A.M. and F.M.A, Bar. 2008. Taxodione, a DNA-binding compound from Taxodium distichum L.(Rich.). Zeitschrift für Naturforschung C. 63(5-6): 355-360.
