A new structure for microchip capillary electrophoresis with high velocity and resolution and efficiency
الموضوعات : Majlesi Journal of Telecommunication Devices
Seyyedeh Sepideh Taheri Otaghsara
1
()
Bahram Azizollah Ganji
2
()
Morteza Fathipur
3
()
الکلمات المفتاحية: resolution, separation time, Efficiency, en, microchip capillary electrophoresis,
ملخص المقالة :
Separation of charged particles is a major problem in biological and chemical researches. There are several techniques for separate charged particles, one of them is electrophoresis. electrophoresis separates electrically charged particles by applying external uniform electric field. In recent years,conventionalcross-form of geometry has been used for microchip electrophoresis. this paper represents new cross-form geometry of microchip capillary electrophoresis with low separation time and high resolution and efficiency and are respectively equal to 100s,3.1,1166.5 while these values for conventional geometries are respectively equal to 120s,2.85,1004.8. these geometries are simulated by comsol.
[1] P. S. Dittrich, K. Tachikawa and A. Manz, “Micro total analysis systems. Latest advancements and trends, ”
Analytical Chemistry, vol.78,pp.3887,jun. 2006.
[2] W. K. T. Coltro, E. Piccin, E. Carrilho, D. P. de Jesus, J. A. F. da Silva, H. D. T. da Silva and C. L. do Lago, Quim, “A toner-mediated lithographic technology for rapid prototyping of glass microchannels, ” lab on chip, vol.30, pp.1986, Nova. 2007.
[3] J. West, M. Becker, S. Tombrink and A. Manz, “ Micro total analysis systems. latest achievements, ” Analytical Chemistry, vol.80,pp.4403 , 2008.
[4] A. Arora, G. Simone, G. B. Salieb-Beugelaar, J. T. Kim and A. Manz, “ Latest developments in micro total analysis systems, Analytical Chemistry, vol. 82, pp.4830, 2010.
[5]DongqingLi, “Electrokinetics in Microfluidics, ”, ELSEVIER ,pp. 28, 2004.
[6]Laugere, F., Guijt, R.M., Bastemeijer, J., Van Der Steen, G.,Berthold, A., Baltussen, E., Sarro, P., Van Dedem,
G.W.K.,Vellekoop, M.J., and Bossche, “On-chip contactless four-electrode conductivity detection for capillary electrophoresis devices, ” Analytical Chemistry,vol. 75,pp.306–312, Jan .2003.
[7]Berthold, A., Laugere, F., Schellevis, H., de Boer, C.R.,Laros, M., Guijt, R.M., Sarro, P.M., and Vellekoop, M.J “Capillary electrophoresis and microchip capillary electrophoresis ”, Electrophoresis ,vol.22,pp. 3511–3519,2001.
[8]Chien-HsiungTsai , Ruey-Jen Yang,Chang-Hsien Tai , Lung-Ming Fu, “Numerical simulation of electrokinetic injection techniques in capillary electrophoresis microchips, ”, electrophoresis,vol.26,pp.674-686, 2005.
[9]chiang , “principle of electrophoresis, ”, mai university,pp.13-17,1994.
[10]Marko stojkovic, Peter C. Hauser, Edwin C. Constable , “Further Development and Applications of Capillary Electrophoresis with Capacitively Coupled ContactlessConductivity Detection and
Sequential Injection Analysis in Analytical Chemistry, ”,pp.13,2013.
[11]Sergey V. Ermakov, Stephen C. Jacobson, and J. Michael Ramsey, “Computer Simulations of Electrokinetic Injection Techniques in Microfluidic Devices, ”, Analytical Chemistry, pp.3512-3517,2000.
[12]H. Niazmand, J. Jamaati, M. Renlsizbulut, “ Investigation of electrokinetic mixing in 3D non-homogenous microchannels, ” Journal Of Computational And Applied Research In Mechanical Engineering,Vol. 3, No. 1, pp. 41-52, 2013.
[13]J.Jamaati, A. R. Farahinia, H. Niazmand, “ Numerical Investigate of Electroosmotic Flow in Heterogeneous Microchannels, ”, ModaresMechanical Engineering,Vol. 15, No. 3, pp. 260-270,2015.
[14]J. H. Masliyah , “Electrokinetik transport phenomena, ” Alberta Oil Sands Tecnology and Research Authority, 1994.
[15]Rajiv Bharadwaj, Juan G. Santiago,Bijan Mohammadi, “Design and optimization of on-chip capillary
electrophoresis, ” Chemical Engineering Department, electrophoresis,pp.2729-2731, 2002.
[16] McCabe, L. W., Smith, J. C., Harriott, P., “ Unit Operations of
Chemical Engineering, ”, McGraw-Hill Book Co., Singapore, pp.521–587, 1993.
