Spark Motor Program reduced oxidative stress in boys with Down syndrome
الموضوعات : Journal of Physical Activity and Hormones
Atefeh Jan Mohammadi
1
(MS in Exercise Physiology, Department of Exercise physiology, Marvdasht branch, Islamic Azad University, Marvdasht, Iran.)
Mehrzad Moghadasi
2
(Associate Professor in Exercise Physiology, Department of Exercise physiology, Shiraz branch, Islamic Azad University, Shiraz, Iran)
الکلمات المفتاحية: Malondialdehyde, Oxidative stress, Spark training, Down syndrome,
ملخص المقالة :
Introduction: Oxidative stress (OS) level is higher in individuals with Down syndrome (DS). Malondialdehyde (MDA) is a marker for lipid peroxidation and the effect of exercise training on MDA in DS patients is not well known. The aim of this study was to examine the effects of selected Spark Motor Program on MDA in boys with DS. Material & Methods: Twenty Down syndrome boys aged between 10~14 participated in this study as the subjects. The subjects were randomly divided into experimental group (n=10) or control group (n=10). The experimental group was performed selected Spark Motor Program 3 days a week for 8 weeks. MDA concentration was measured before and 48h after the intervention. Results: The results showed that MDA decreased after 8 weeks selected experimental in compare to the control group. Conclusions: In summary, Spark Motor Program that selected in this study decreases MDA of boys with DS.
References
1. Muchová J, Žitňanová I, Ďuračková Z. Oxidative stress and Down syndrome. Do antioxidants play a role in therapy? Physiol Res 2014; 63: 535-542.
2. World Health Organization. Down syndrome. Genes and human diseases. World Health Organization; 2007.
Available at: http://www.who.int/genomics/public/ geneticdiseases/en/print.html.
3. Kaneshiro NK. Intellectual disability. MedlinePlus, U.S. National Library of Medicine, 2016. Available at: https://medlineplus.gov/ency/article/001523.htm.
4. Faal Moghanlo H, Hosseini F, Mikaili Manee F. Effect of Spark Motor Program on the development of gross motor skills in Down syndrome boys. J Birjand Univers Med Sci 2013; 20: 262-270.
5. Daily DK, Ardinger HH, Holmes GE. Identification and evaluation of mental retardation. Am Fam Physician 2000; 61: 1059-1067.
6. Ribeiro LMA, Jacob CMA, Pastorino AC, KimCA, Fomin AB, Castro AP. Avaliação dos fatores associados a infecções recorrentes e/ou graves empacientes com Síndrome de Down. J Pediatr (Rio J) 2003; 79: 141-148.
7. ShichiriM, Yoshida Y, IshidaN, Hagihara Y, Iwahashi H, TamaiH, et al. α-Tocopherol suppresses lipid peroxidation and behavioral and cognitive impairments in the Ts65Dn mouse model of Down syndrome. Free Radic Biol Med 2011; 15: 1801-1811.
8. Sies H. Oxidative stress, Academic Press, London; 1985, pp: 1-507.
9. Mazza M, Pomponi M, Janiri L, Bria P, Mazza S. Omega-3 fatty acids and antioxidants in neurological and psychiatric diseases: an overview. Prog Neuropsychopharmacol Biol Psychiatry 2007; 31: 12-26.
10. Siti HN, Kamisah Y, Kamsiah J. The role of oxidative stress, antioxidants and vascular inflammation in cardiovascular disease (a review). Vascul Pharmacol 2015; 71: 40-56.
11. Radi E, Formichi P, Battisti C, Federico A. Apoptosis and oxidative stress in neurodegenerative diseases. J Alzheimers Dis 2014; 42: S125-S152.
12. Wruck CJ, Fragoulis A, Gurzynski A, Brandenburg LO, Kan YW, Chan K, et al. Role of oxidative stress in rheumatoid arthritis: insights from the Nrf2-knockout mice. Ann Rheum Dis 2011; 70: 844-850.
13. Maiese K. New insights for oxidative stress and diabetes mellitus. Oxid Med Cell Longev 2015; 2015: 875961.
14. Sosa V, Moliné T, Somoza R, Paciucci R, Kondoh H, LLeonart ME. Oxidative stress and cancer: an overview. Ageing Res Rev 2013; 12: 376-390.
15. Chen Z, Zhong C. Oxidative stress in Alzheimer's disease. Neurosci Bull 2014; 30: 271-281.
16. Shaw PX, Werstuck G, Chen Y. Oxidative stress and aging diseases. Oxid Med Cell Longev 2014; 2014: 569146.
17. Carratelli M, Porcaro L, Ruscica M, De Simone E, Bertelli AA, Corsi MM. Reactive oxygen metabolites and prooxidant status in children with Down's syndrome. Int J Clin Pharmacol Res 2001; 21: 79-84.
18. Flore P, Bricout VA, van Biesen D, Guinot M, Laporte F, Pépin JL, et al. Oxidative stress and metabolism at rest and during exercise in persons with Down syndrome. Eur J Cardiovasc Prev Rehabil 2008; 15: 35-42.
19. Zambrano JC, Marquina R, Sulbarán N, Rodríguez-Malaver AJ, Reyes RA. Aerobic exercise reduced oxidative stress in saliva of persons with Down syndrome. Res Sports Med 2009; 17: 195-203.
20. Barnhart RC, Connolly B. Aging and Down syndrome: implications for physical therapy. Phys Ther 2007; 87: 1399-1406.
21. Takahashi M, Miyashita M, Kawanishi N, Park JH, Hayashida H, Kim HS, et al. Low-volume exercise training attenuates oxidative stress and neutrophils activation in older adults. Eur J Appl Physiol 2013; 113: 1117-1126.
22. Li G, Liu JY, Zhang HX, Li Q, Zhang SW. Exercise training attenuates sympathetic activation and oxidative stress in diet-induced obesity. Physiol Res 2015; 64: 355-367.
23. Dodd KJ, Shields N. A systematic review of the outcomes of cardiovascular exercise programs for people with Down syndrome. Arch Phys Med Rehabil 2005; 86: 2051-2058.
24. Lotan M. Quality physical intervention activity for persons with Down syndrome. ScientificWorldJournal 2007; 7: 7-19.
25. Ulrich DA. Test of gross motor development-2. Austin, T.X.: Prod-Ed Press; 2000.
26. Rezvankhah Golsefidi N, Emami Hashemi SA. Effect of Selected Spark Motor Program on anxiety of children with asperger. Physic Treat 2015; 5: 83-88.
27. Gulesserian T, Seidl R, Hardmeier R, Cairns N, Lubec G. Superoxide dismutase SOD1, encoded on chromosome 21, but not SOD2 is overexpressed in brains of patients with Down syndrome. J Investig Med 2001; 49: 41-46.
28. Muchova J, Sustrova M, Garaiova I, Liptakova A, Blazicek P, Kvasnicka P, et al. Influence of age on activities of antioxidant enzymes and lipid peroxidation products in erythrocytes and neutrophils of Down syndrome patients. Free Radic Biol Med 2001; 31: 499-508.
29. Pallardo FV, Degan P, d’Ischia M, Kelly FJ, Zatterale A, Calzone R, et al. Multiple evidence for an early age pro-oxidant state in Down syndrome patients. Biogerontology 2006; 7: 211-220.
30. Sinet PM. Metabolism of oxygen derivatives in Down’s syndrome. Ann N Y Acad Sci 1982; 396: 83-94.
31. Casado A, López-Fernández ME, Ruíz R. Lipid peroxidation in Down syndrome caused by regular trisomy 21, trisomy 21 by Robertsonian translocation and mosaic trisomy 21. Clin Chem Lab Med 2007; 45: 59-62.
32. Gustaw-Rothenberg K, Kowalczuk K, Stryjecka-Zimmer M. Lipids' peroxidation markers in Alzheimer's disease and vascular dementia. Geriatr Gerontol Int 2010; 10: 161-166.
33. Meguid NA, Eltohamy AM, Anwar M, Hashish AF, Elnahry A. Efficacy of selected treadmill training programme on oxidative stress in adolescents with Down syndrome. East Mediterr Health J 2014; 19: S131-S137.
34. Javier Ordonez F and Rosety-Rodriguez M. Regular exercise attenuated lipid peroxidation in adolescents with Down's syndrome. Clin Biochem 2007; 40: 141-2.
35. Brites F, Zago V, Verona J, Muzzio ML, Wikinski R, Schreier L. HDL capacity to inhibit LDL oxidation in well-trained triathletes. Life Sci 2006; 78: 3074-3081.
36. Apor P and Rádi A. Physical exercise, oxidative stress and damage. Orv Hetil 2006; 147: 1025-1031.
