تاثیر دویدن روی چرخ دوار پیچیده بر بتا آمیلوئید، نپریلیسین خون، بیان کبدی LRP1 و PPARγ در موش های صحرایی مدل بیماری آلزایمر
تاثیر دویدن بر بتا آمیلوئید، نپریلیسین LRP1 و PPARγ در آلزایمر
الموضوعات :
نادیا تاجوانچی
1
(دانشجوی دکتری تخصصی فیزیولوژی ورزشی دانشگاه آزاد تبریز)
رسول اسدی هاشم کندی
2
(عضو هیأت علمی گروه علوم ورزشی، واحد تبریز، دانشگاه آزاد اسلامی)
رقیه پوزش
3
(استادیارگروه تربیت بدنی دانشگاه آزاد تبریز)
فرزاد زهساز
4
(هیئت علمی آزاد تبریز)
کریم آزالی علمداری
5
(دانشگاه شهید مدنی)
الکلمات المفتاحية: چرخ دوار پیچیده, بتا آمیلوئید, نپریلیسین خون, بیان کبدی LRP1, PPARγ, بیماری آلزایمر,
ملخص المقالة :
زمینه و هدف: ورزش و فعالیت بدنی می تواند در به تاخیر انداختن آلزایمر نقش موثری داشته باشد. مکانیسم های مولکولی متعددی توسط فعالیت های بدنی مختلف فعال می شوند که شاخص های زوال عقل را تقلیل می دهند و هدف از پژوهش حاضر بررسی تاثیر دویدن روی چرخ دوار پیچیده بر بتا آمیلوئید، نپریلیسین خون، بیان کبدی LRP1 و PPARγ در موش های صحرایی مدل بیماری آلزایمر بود. مواد و روش ها: 24 موش صحرایی به صورت تصادفی انتخاب و در سه گروه: کنترل سالم، گروه کنترل آلزایمری و گروه آلزایمر+ تمرین چرخ گردان پیچیده تقسیم شدند. گروه تمرینی به اجرای 12 هفته تمرین پرداختند وگروه کنترل نیز به مدت 12 هفته در قفس نگهداری شدند و در هيچ تمرينی شركت داده نشدند. تمرین موش ها روی چرخ دوار پیچیده و به مدت 12 هفته بود، همچنین در انتهای هفته 12 موش ها مبتلا به آلزایمر شده و از آن ها تست های شاتل باکس جهت اطمینان از القا بیماری آلزایمر گرفته شد. در این تحقیق به منظور بررسی تغییرات کبدی متغییر های یاد شده به روش آلایزا مورد بررسی قرار گرفت. به منظور تجزیه و تحلیل داده‌ها از آزمون تحلیل واریانس یک راهه استفاده شد. نتایج: نتایج نشان داد تفاوت معنی داری بین بتا آمیلوئید و بیان کبدی LRP1 موش های صحرایی گروه آلزایمر کنترل با بتا آمیلوئید و بیان کبدی LRP1 موش های صحرایی گروه تمرین چرخ پیچیده وجود ندارد. اما تفاوت معنی داری بین نپریلیسین خون PPARγ موش های صحرایی گروه آلزایمر کنترل با نپریلیسین خون و PPARγ موش های صحرایی گروه تمرین چرخ پیچیده وجود دارد. نتیجه گیری: استفاده از فعالیت بدنی می تواند نپریلیسین خون و PPARγ را در موش های صحرایی بهبود بخشد اما بهبود بتا آمیلوئید و بیان کبدی LRP1 نیازمند پژوهش های بیشتر می باشد. کلمات کلیدی: چرخ دوار پیچیده، بتا آمیلوئید، نپریلیسین خون، بیان کبدی LRP1، PPARγ، بیماری آلزایمر
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