A Novel protocol for synthesis of Hantzsch 1, 4- dihydropyridines using PEG-400 as a reaction medium and under catalyst-free condition
الموضوعات : International Journal of Heterocyclic Chemistry
Ali Ezabadi
1
(Department of Chemistry, Faculty of Sciences, Islamic Azad University, Central Tehran Branch, Sanat Square, Iran)
Fatemeh Tosan
2
(Department of Chemistry, Faculty of Sciences, Islamic Azad University, Central Tehran Branch, Sanat Square, Iran)
الکلمات المفتاحية: Hantzsch 1, 4 – dihydropyridines, PEG-400, Three-component reaction, catalyst-free, Aldehydes, ethyl acetoacetate, ammonium acetate,
ملخص المقالة :
An efficient and expeditious catalyst-free procedure was developed for the one- pot synthesis of 1, 4-dihydropyridine derivatives via the three-component reaction of various aldehydes, ethyl acetoacetate, and ammonium acetate in PEG-400. The reaction was carried out at 110°С and the products were obtained in good to high yields.
