Novel synthesis of Pyrimido[4,5- e] [1,3,4] thiadiazines

الموضوعات : International Journal of Heterocyclic Chemistry

Abdolhassan Doulah ¹ , Hamid Sadeghian ²

1 - Department of Nursing, Faculty of Nursing and Midwifery, Islamic Azad University, Ahvaz Branch, Ahvaz
2 - Department of Laboratory Sciences, School of Paramedical Sciences, Mashhad University of Medical Sciences, Mashhad, Iran

تاريخ الإرسال : 18 الأربعاء , شعبان, 1437 تاريخ التأكيد : 18 الأربعاء , شعبان, 1437 تاريخ الإصدار : 27 الأحد , جمادى الأولى, 1432

الکلمات المفتاحية: 1-(5-bromo-2-chloro-6-methylpyrimidin-4-yl)-1-methylhydrazine, pyrimidothiadiazine, dimethylthiocarbamoylchloride, 15- lipoxygenase,

ملخص المقالة :

Treatment of 1-(5-bromo-2-chloro-6-methylpyrimidin-4-yl)-1-methylhydrazine with dimethylthiocarbamoylchloride gave 7-chloro-N,N,1,5-tetramethyl-1H-pyrimido[4,5-e][1,3,4]thiadiazin-3-amine in basic acetonitrile. The latter compounds were reacted with secondary amines in boiling ethanol to afford the related 7-amino derivatives.