Biginelli Synthesis and Theoritical Study of Dihydropyrimidinone Compounds

الموضوعات : International Journal of Heterocyclic Chemistry

Mohammad Hosein Farjam ¹ , Ramin Rezaei ²

1 - Department of Chemistry , Firoozabad Branch, Islamic Azad University,Firoozabad, Iran
2 - Department of Chemistry , Firoozabad Branch, Islamic Azad University,Firoozabad, Iran

تاريخ الإرسال : 12 الأربعاء , صفر, 1439 تاريخ التأكيد : 02 الجمعة , جمادى الأولى, 1439 تاريخ الإصدار : 13 الخميس , جمادى الثانية, 1439

الکلمات المفتاحية:

ملخص المقالة :

An effective one-pot synthesis of dihydropyrimidinonoes in solvent free conditions using CuCl2 as an inexpensive and readily available reagent through Biginelli condensation reaction of aldehyde derivatives, 1,3-dicarbonyl compounds and urea is described. Excellent yields, short reaction times for formation of the products and simple work-up are attractive features of this green protocol.