A novel investigation on the characterization of bioactive glass cement and chitosan-gelatin membrane for jawbone tissue engineering
الموضوعات : Journal of NanoanalysisFarhad Ghomi 1 , َAzadeh Asefnejad 2 , Morteza Daliri 3 , Vahabeddin Godarzi 4 , Mehran Hemati 5
1 - Faculty of Biomedical Engineering, Islamic Azad University, Science and Research Branch, Tehran, Iran
2 - Assistant professor of biomedical engineering
3 - School of Chemical Engineering, College of Engineering, University of Tehran, Tehran, Iran
4 - 2 School of Chemical Engineering, College of Engineering, University of Tehran, Tehran, Iran
3 Applied Biotechnology Research Center, Baqiyatallah University of Medical Science, Tehran, Iran.
5 - 4 Dental School, Shiraz University of Medical Sciences, Shiraz, Iran.
الکلمات المفتاحية: sol-gel, Tissue Engineering, bioactive glass, Chitosan-gelatin membrane,
ملخص المقالة :
The aim of this work was to investigate the characterization of a bioactive glass(BG) ceramic prepared by sol-gel technique and chitosan-gelatin membranesprepared by lyophilization technique containing 0, 1, and 2 vol.% ethanol. Earlyabsorbingand late-absorbing bone substitutes in practice constitute the mainvolume of bone substitutes used by dentists and orthopedic surgeons. Whenthe graft is to be gradually replaced by normal bone, the important issue is theduration and rate of graft absorption. The prepared samples were characterizedusing Fourier transformed infrared spectroscopy (FTIR) and X-ray diffraction (XRD)analysis. The presence of Ag nanoparticles in bioactive glass was evaluated.Porous membranes were examined under scanning electron microscopy (SEM)to estimate the size of the pores and analysis the morphological behavior. Thepore diameter could be controlled within the range of 10–30 μm by adjusting thepercentage of ethanol. The formation of needle-like hydroxyapatite (HA) crystals onthe surface of the membrane after 7 days of immersion in the ringer's solution wasalso assessed using SEM images. The SEM image results illustrated the porousstructures in the membranes. The average pore size for chitosan-gelatin membranewith 2% ethanol was 30±6.3 μm. Finally, these obtained results suggest thatthe developed membrane with 2% ethanol possesses the prerequisites for tissueengineering and can be used for jawbone tissue engineering applications.
