مروری بر تأثیر اعتیاد به مواد مخدر بر روی عملکرد و ساختار مغز بر مبنای تحلیل سیگنال‌های الکتروانسفالوگرام

عاطفه توبیها ¹ (دانشکده مهندسی برق- واحد نجف‌آباد، دانشگاه آزاد اسلامی، نجف‌آباد، ایران) ندا بهزادفر ² (مرکز تحقیقات پردازش دیجیتال و بینایی ماشین- واحد نجف‌آباد، دانشگاه آزاد اسلامی، نجف‌آباد، ایران)
محمد رضا یوسفی ³ (مرکز تحقیقات ریزشبکه‌های هوشمند- واحد نجف‌آباد، دانشگاه آزاد اسلامی، نجف‌آباد، ایران)
همایون مهدوی نسب ⁴ (دانشکده مهندسی برق- واحد نجف‌آباد، دانشگاه آزاد اسلامی، نجف‌آباد، ایران)

تاريخ الإرسال : 22 الجمعة , شوال, 1444 تاريخ التأكيد : 19 الأربعاء , ربيع الأول, 1445

الکلمات المفتاحية: اعتیاد, استخراج ویژگی, سیگنال الکتروانسفالوگرام, طیف قدرت,

ملخص المقالة :

اعتیاد به مواد مخدر سبب ایجاد تغییرات ساختاری و عملکردی در مغز انسان می گردد و می توان آن را به عنوان یک بیماری مزمن در نظر گرفت. تاکنون مطالعات مختلفی جهت بررسی اعتیاد بر روی سیگنال الکتروانسفالوگرام (EEG) انجام شده که از نظر روش، شرایط تجربی، نمونه ها و نتایج متفاوت هستند. بررسی مطالعات قبلی و روش های تجربی جهت بررسی بهتر مسائل و چالش های موجود در طراحی مطالعات اعتیاد ضروری است. سیگنال الکتروانسفالوگرام، به عنوان یک ابزار غیرتهاجمی دارای توانایی بالقوه جهت بررسی فعالیت عملکردی و شناختی مغز است. از الکتروانسفالوگرام می توان جهت بررسی ارتباط تغییرات ایجاد شده در مغز در اثر مصرف مواد مخدر استفاده کرد. در این مقاله به بررسی تغییرات ایجاد شده در سیگنال الکتروانسفالوگرام در اثر مصرف مواد و همچنین پس از ترک مواد مخدر اشاره خواهد شد. نتایج نشان می دهد که مصرف مواد مخدر سبب کاهش پردازش توجه و ایجاد اختلالات عملکردی و ناهنجاری های مغزی می گردد. در افراد معتاد افزایش فعالیت زیرباندهای بتا و دومین زیرباند آلفا، تأخیر در رخداد و کاهش دامنه P300 مشاهده شده است. همچنین نسبت توان زیرباند آلفا به تتا در T6 کاهش نشان داده و اختلاف معنا دار در زیرباند دلتا به زیرباند آلفا در نسبت توان مشاهده شده است. یافته ها نشان می دهند که ولع و سابقه مصرف مواد افراد بر توان سیگنال الکتروانسفالوگرام تأثیر می گذارد. فعالیت عصبی در زیرباند آلفای افرادی که اعتیاد را ترک کرده اند نیز به طور معنی داری در لوب پاریتال (BA3 و BA7)، لوب فرونتال (BA4 و BA6) و لوب لیمبیک (BA24) ضعیف تر است.

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