اثر کاربرد اسانس گیاه آویشن در بافت شناسی روده موش صحرایی

Subject Areas : Journal of Medicinal Herbs, "J. Med Herb" (Formerly known as Journal of Herbal Drugs or J. Herb Drug)

حشمت سپهری مقدم ¹ , مژده عمادی ² , الهام ملاشاهی ³

1 - گروه کشاورزی، دانشگاه پیام نور تهران، تهران، ایران
2 - گروه کشاورزی، دانشگاه پیام نور تهران، تهران، ایران
3 - گروه کشاورزی، دانشگاه پیام نور تهران، تهران، ایران

Received: 2014-05-25 Accepted : 2014-06-09 Published : 2014-04-01

Keywords: آویشن, روده کوچک, ایندومتاسین,

Abstract :

مقدمه و هدف:  داروهای ضدالتهاب غیراستروئیدی در پزشکی بالینی استفاده می شوند. اگرچهگاهی اثرات خاصی در دستگاه گوارش ایجاد می­نمایند. استفاده خوراکی داروی ایندومتاسین باعث بروز استرس اکسیداتیو در روده کوچک می­شود. روش تحقیق:  تاثیر آویشن که دارای خصوصیات آنتی­اکسیدانی است بر موش­هائی که با ایندومتاسین تغذیه اجباری شده­بودند, بررسی شد.مواد موثره آویشن از طریق اسپکتوفتومتری گاز کروماتوگرافی تعیین شد. نتایج و بحث: ارتفاع پرز, عرض پرز, ارتفاع کریپت و عرض کریپت در دئودنوم, ژژنوم و ایلئوم موش­­های تغذیه شده با ایندومتاسین و تیمار شده با آویشن در مقایسه با موش­های تغذیه شده با ایندومتاسین بهبود معنی­داری نشان داد. توصیه کاربردی/ صنعتی: تیمول حاصل از انسانس آویشن به عنوان ماده ای موثر در جهت کاهش اثرات زیانبار داروی ایندومتاسین توصیه می­شود.

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