Inhibitory effects of Behind the scenes medicine extract (Physalis alkekengi) on prostate cancer caused by DMBA injection in mice

Subject Areas : Developmental biology of plants and animals , development and differentiation in microorganisms

Maryam Teimouri ¹ (Biology..islamic azad university Roudehen branch. Tehran.Iran)
fariba khosravinejad ² (گروه زیست شناسی، واحد تهران شمال، دانشگاه آزاد اسلامی، تهران، ایران)

Received: 2021-02-28 Accepted : 2021-06-17 Published : 2021-05-22

Keywords: anticancer, physalis alkekengi, DMBA, prostate cancer,

Abstract :

Introduction: Although many clinical and pre-clinical studies have widely demonstrated the therapeutic effects of hydroalcoholic extract of the puppet pup on several diseases, there is little information on the therapeutic properties of this plant's hydroalcoholic extract on prostate cancer. In this study, we evaluated the therapeutic effects of hydroalcoholic extract of Physalis alkekengi extract on prostate cancer induced by injection of 12.7-dimethylbenzanthracene (DMBA) (a carcinogenic drug) on mouse modelMaterials and Methods: After induction of anesthesia, DMBA was injected directly into the prostate gland of male rats and after 14 days, rats received different amounts of puppet extract every 48 hours and by the end of day 21, intraperitoneal injection of puppet extract. In the control group, intraperitoneal injection of normal saline was performed.Results: The results showed that the puppet extract significantly reduced prostate weight, especially at two concentrations (100 mg, 500, and 1000). Histopathological changes were also observed in the prostate tumors of p.alkekengi extract treated groups compared to the control group.Conclusion: It is suspected that the hydroalcoholic extract of the p.alkekengi inhibits abnormal growth, precancerous lesions, and DMBA-induced carcinoma in the BALB / c mouse prostate.