Review of the photodynamic therapy with the approach of different photosensitizers
Subject Areas : Developmental biology of plants and animals , development and differentiation in microorganismsParnia Hemmati 1 , Seyed Mehdi Tabaie 2 , Mina sadat Naderi 3
1 - Department of Biology, Faculty of Biological Sciences, North Tehran Branch, Islamic Azad University, Tehran, Iran.
2 - Department of Medical Laser, Medical Laser Research Center, Yara Institute, Academic Center for Education Culture and Research ACECR), Tehran, Iran.
3 - Department of Biophysics, Faculty of Biological Sciences, North Tehran Branch, Islamic Azad University, Tehran, Iran
Keywords: cancer, Skin, Photodynamic therapy, optical sensors, low-power laser,
Abstract :
Photodynamic therapy is a minimally invasive treatment for diseases such as cancer. The photosensitizer, which acts as a catalyst upon absorption of light, converts oxygen into cytotoxic reactive oxygen species that destroy malignant cells through apoptosis or necrosis, destroy tumor vasculature, and Stimulate immunity. An active photosensitizer activated by a specific biomarker is able to distinguish healthy from diseased cells, thereby reducing off-target photodamage. The purpose of this study is to introduce and evaluate the performance of different types of photosensitizers in the treatment of various diseases, including skin diseases and skin cancer with the photodynamic therapy method. In this review study, the articles of the last 10 years on the sites google scholar, PubMed, science direct, and Scopus, with the titles of photosensitizers, photodynamic therapy, cancer, skin, and low-power laser were reviewed. There are different treatment methods for cancer, and photodynamic therapy is a promising treatment method for all types of cancer. One of the advantages of this method is the use of non-ionizing radiation, which leads to minimal damage to DNA and surrounding tissues, so this method can improve the method by using different photosensitizers with different optical wavelengths according to the target tissue. treatments with their unique mechanism to have a helpful effect.
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