Synthesis and characterization of conductive hydrogel nanocomposite for controlled drug delivery of cis-platin

Subject Areas :

حسن فتحی نژاد جیرندهی ¹ (استادیار شیمی آلی، گروه شیمی، واحد فراهان، دانشگاه آزاد اسلامی، فراهان، ایران)
مروارید نباتی احمدی ² (کارشناسی ارشد مهندسی شیمی، گروه شیمی، واحد فراهان، دانشگاه آزاد اسلامی، فراهان، ایران)
معصومه مسکین فام ³ (استادیار شیمی معدنی، گروه شیمی، واحد لاهیجان، دانشگاه آزاد اسلامی، لاهیجان، ایران)

Received: 2017-04-27 Accepted : 2018-01-27 Published : 2019-02-20

Keywords: Carbon nanotubes, Guar, Drug release, Conductivity, Hydrogel nanocomposite,

Abstract :

The present work is including synthesis and characterization of conductivity of a super-absorbent conductive hydrogelnanocomposte and its controlled drug release. For this purpose, superabsorbent conductive hydrogel by Guar gum was synthesized based on grafting copolymerization of acrylic acid monomer and proximity of some carbon nanotubes; in addition, polymerization reaction was done in aqueous phase )distilled water( and in the presence of ammonium persulfate as initiator and Methylene bisacrylamide as cross-linked. The results were assessed by FT-IR, cyclic Voltammetry and Scanning Electron microscope. However, the effect of carbonnanotube’s amount on nanocomposite was characterized by increasing this amount, the gel content, equilibrium swelling in distilled water, pH sensitivity, and conductivity increases. In the second stage, cisplatin drug was loaded in hydrogelnao composite and the percentage of drug release in phosphate buffer solution )PBS( was measured by appropriate electrical stimulation. The results show that the synthesized hydrogel is reasonable option for controlled drug release

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