Synthesis of tin oxide-maghemite magnetic nanocomposite coated with chitosan pH-sensitive polymer and investigation of quercetin loading and release conditions

Subject Areas :

Maziar Ashouri ¹ (دانشجوی کارشناسی ارشد مهندسی شیمی، دانشکده مهندسی شیمی، دانشگاه صنعتی نوشیروانی، بابل، ایران)
mohsen ghorbani ² (دانشیار مهندسی شیمی، دانشکده مهندسی شیمی، دانشگاه صنعتی نوشیروانی، بابل، ایران)
sohrab kazemi ³ (استادیار گروه فارماکولوژی، دانشکده پزشکی، دانشگاه علوم پزشکی، بابل، ایران)

Received: 2021-02-15 Accepted : 2021-02-15 Published : 2021-02-19

Keywords: nanocomposite, Quercetin, Drug loading, Nanocarrier,

Abstract :

The aim of this study was to investigate the loading and release conditions of quercetin using a pH-sensitive nanocarrier. Initially, tin oxide nanoparticles and magnetic nanocomposites were synthesized; then, chitosan biopolymer functionalized with folic acid was used to coat the magnetic nanocomposite. In order to optimize the nanocarrier, loading times (4, 3, 2, 1 and 5 hours), the amount of nanocarrier (10.5 and 15 mg), drug concentration (15, 25, 35, and 50 ppm), and solvent (methanol and Ethanol) were investigated with an iron to tin ratio of 0.2. Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), scanning electron microscopy (SEM), and particle size distribution were used to investigate the properties of nanoparticles, and according to the results, synthesized nanocomposites had a homogenous structure with particle size between 5 to 25 nm, the amount of carrier was 10 mg, the concentration of the drug was 15 ppm with methanol solvent and the loading time was 4 hours with a maximum loading efficiency of 85% and was selected as the optimal nanocarrier. The maximum adsorption capacity was obtained based on the Langmuir model and Sips were 36.2322 mg / g and 37.3915 mg / g, respectively. Absorption synthetic studies have shown that quercetin adsorption has followed second-degree synthetics. In order to evaluate the intelligent release of the drug, its release in laboratory conditions using phosphate salt solution with buffer properties in different pHs was investigated and the synthesized nanocarrier showed complete release in the acidic pH of 2.5.

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