UV-Visible spectrophotometry of Repaglinide in bulk and in formulation by using methyl orange as reagents
Subject Areas : Journal of the Iranian Chemical ResearchSmita Sharma 1 , Mukesh Sharma 2
1 - Department of Chemistry Chodhary Dilip Singh Kanya Mahavidyalya Bhind (M.P) 477001, India
2 - School of Pharmacy, Devi Ahilya Vishwavidyalaya, Indore (M.P)-452001, India
Keywords:
Abstract :
[1] M.D.Rockville, United States Pharmacopoeia; 25th (Eds) United States Pharmacopoeial Convention
Inc, (2002) 2150.
[2] S.Budavari, the Merck Index. 13th (eds) Whitehouse Station (NJ, USA) Merck and Co Inc (2001) 790.
[3] J.E.F Reynolds, Martindale, 33 rd ed. (London), the Complete Drug Reference Pharmaceutical Press,
(2002) 334.
[4] M.D. Rockville, United State Pharmacopoeia, (Asian Eds) USP Convention Inc, (2003) 623.
[5] A.B. Ruzilawati, M.S. Wahab, A. Imran, Z. Ismail, S.H. Gan, J. Pharm. Biomed. Anal. 43 (2007)
1831-1835.
[6] M. Gandhimathi, T.K. Ravi, S.K. Renu, Anal. Sci. 19 (2002) 1675-1677.
[7] R.H. Khan, S. Talegaonkar, R.M. Singh, S.C. Mathur, R. Shiv, G.N. Singh, Indian Drugs 44 (2007)
428-433.
[8] A. Gumieniczek, A. Berecka, H. Hopkała, J. Planar Chromatogr. 18 (2005) 155-159.
Parameters Repaglinide
Method I Method II
Working λ (nm) 485.2 nm
618.9 nm
Beer’s law limit (μg mL-1) 5-35 5-35 5-35 0-45
Correlation coefficient * 0.9965 0.9994 0.9998 0.9999
Intercept * 0.0003 0.0014 0.0043 0.0021
Slope * 0.0143 0.0221 0.0651 0.0765
Limit of detection, μg mL-1 2.17 -0.74
Limit of quantification, μg mL-1 1.08 0.18
S. Sharma & M.Ch. Sharma / J. Iran. Chem. Res. 4 (2011) 69-76
76
[9] A. Goyal, I. Singhvi, Indian. J. Pharm. Sci. 68 (2006) 656-657.
[10] ICH, Stability Testing of New Drug Substances and Products, in: Proceeding of the International
Conference on Harmonisation, IFPMA, Geneva, (2003).
[11] M. Bakshi, S. Singh, J. Pharm. Biomed. Anal. 28 (2003) 1011-1040.
[12] A.B. Thomas, M.R. Patankar, K.R. Deshmukh, L.P. Kothapalli, S.J. Jangam, S.H. Bodkhe, A.D.
Deshpande, Indian Drugs 44 (2007) 745-750.
[13] S.B. Chepurwar, A.A. Shirkhedkar, S.B. Bari, S.J. Surana, S.J. Indian Drugs 43 (2006) 803-806
[14] A.G. Davison, A.H. Beckette, J.B. Stenlake, Practical Pharmaceutical Chemistry, CBS Publishers
and distributors, New Delhi.275 (1997).