Kisspeptin, GnRH, Prolactin and Ovarian Hormones Levels in Hyperprolactinemia, Type 1 Diabetes and Obesity Women

Subject Areas : Journal of Chemical Health Risks

Nakaa Qassim Ghali ¹ (Department of Biology, College of Science, University of Misan, Maysan, Iraq)
Zainab Abduljabbar Ridha Al-Ali ² (Department of Biology, College of Science, University of Misan, Maysan, Iraq)
Saba Jassim Al Heshimi ³ (College of Medicine, University of Misan, Maysan, Iraq)

Received: 2023-08-11 Accepted : 2024-03-16 Published : 2024-05-06

Keywords: Women, Hyperprolactinemia, Kisspeptin, Obesity, GnRH,

Abstract :

Kisspeptin is a peptide that plays a crucial function in the regulation of puberty initiation, by sexual immaturity and slowed puberty advancement. Infertility is a result of hyperprolactinemia, which inhibits the pulsatile release of GnRH from the brain and lowers the pulsatile production of LH from the pituitary. In type 1 diabetes, also known as autoimmune diabetes, pancreatic cells die off and the body cannot produce enough insulin, leading to high blood sugar levels. Obese people are more likely to suffer from hyperinsulinemia, hyperlipidemia, hyperleptinemia, chronic inflammation, menstrual abnormalities, pregnancy troubles, and infertility. So, this study aims to know the reproductive status of women by estimating kisspeptin and other hormones. The study was conducted on 92 women, ages (20-40) years, Samples were collected from the AL-Sader Teaching Hospital, Maysan for Child and Birth Hospital, the specialized Centre for Diabetes and Endocrinology and some private clinics and centres, the period June 2022 to February of 2023. The women were divided equally into four groups: control group (with regular menstrual cycles), hyperprolactinemia group (hyper serum prolactin), obesity group (have a BMI over 30 kg.m–2), and type 1 diabetes group. The results showed the values of kisspeptin did not differ significantly (P>0.05) in all groups, values of GnRH in hyperprolactinemia, obesity and type 1 DM groups increased significantly (P≤0.05) compared with the control group, Prolactin, estradiol and progesterone in the hyperprolactinemia group increased significantly (P≤0.05) in comparison with other groups. According to the above results, we conclude that high levels of prolactin, also obesity and type 1 DM influence the reproductive hormones in women.

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