The Effect of Oral Cyclosporine on Plasma Levels of Parathormone and Calcitonin in Adult Male Rat
Subject Areas : Journal of Animal Biology
حمیده افتخاری
1
(دانشگاه آزاد اسلامی، واحد ارسنجان، گروه زیست شناسی، ارسنجان، ایران)
Keywords: Osteoporosis, Cyclosporine, Calcitonin, Parathormone,
Abstract :
Today, osteoporosis is a popular disorder especially among old people and menopause women, and there are a lot of pathogenic factors which are effective in osteoporosis. Some scientific studies show that those who have to use cyclosporine continuously in a long term, will affected with osteogenesis. Indeed, parathormone and calcitonin can effect on osteogenesis as well. In this study, the researchers try to investigate the relationship between cyclosporine and the mentioned hormones. We have used 60 rats in this study to take their blood only for one time and, we have achieved 6 groups for our statistical analysis. The cyclosporine, saluted in olive oil with dosage of 15 mg/Kg/day, has prescribed to the rats to be taken orally for six weeks. Then we injected only olive oil to the other two remained groups (control) have received nothing. The serum is taken from the samples before and after prescribing the drug. The amounts of mentioned hormones are measured by ELISA method. The final result indicate that the difference of the plasma levels of parathormone between control group and the group that has taken the cyclosporine in Pandlt; 0.05 was not significant. However the plasma level of calcitonin in control group shows a significant decrease to the group that has taken the cyclosporine in Pandlt; 0.05. Osteoporesis that induces with drug is a preventable disease that often hasnandrsquo;t cared about it. Diagnosis of drug causes, treatment via controlling and use preventing parameters could recover of the patients. Investigations suggest some pathways for determine the cellular mechanism of cyclosporine on the osteoporosis. The results indicate that cyclosporine may operate mechanisms with decrease calcitonin and disturb the balance between osteoblast and osteoclast so finally cause osteoporosis.
