The Effects of Hydroalcohlic Walnut Extract of Juglans regia Male Flower on Blood Sugar Level and Liver Enzymes Activity in Intact and Diabetic Adult Male Rat
Subject Areas : Journal of Animal Biology
سید ابراهیم حسینی
1
(دانشگاه آزاد اسلامی، واحد علوم و تحقیقات، گروه زیست شناسی، فارس، ایران)
کاظم کریم زاده
2
(دانشگاه آزاد اسلامی، واحد علوم و تحقیقات، گروه زیست شناسی، فارس، ایران)
Keywords: liver enzymes, Diabetes, Male rat, Streptozotocin, hydroalcoholic extract male flowers walnuts,
Abstract :
Diabetes is a metabolic disorder with hyperglycemia due to defects in secretion, insulin function or both are specified. Walnut nutritional purposes in addition to traditional medicine in Iran is also used to treat diabetes, so this study examines the effect of male flowers on some walnut diabetes on diabetic male rats by measuring the amount of blood sugar and liver enzymes. The study on 80 male rats with 200 to 225 grams weight, which accidentally in three groups were performed. The first group: Control, Second: Diabetic 32 and next Group: Non-diabetic 32 over each of the groups to four are divided into eight categories: (A) The control group received normal saline, (B) treated with experimental group received the extract 2g/kg,) C) Received the extract 4g/kg, (D) Extract the downloaded 6g/kg. Eight rats were used for determination of lethal doses of LD50. For diabetes as IP 60mg/kg of streptozotocin were used. Rat daily for 15 days as a single dose extracts were treated at the end of the fifteenth day from the ventricular blood sampling were performed.Results showed a significant reduction blood sugar and ASAT,ALP in diabetics than non-diabetic group receiving thehydroalcoholic extractof male flowers walnut. However this effect is not dependent dose. In this study hydroalcoholic extract useful effect of male flowers Walnut liver damage due to inhibition and reduced blood sugar and liver enzymes levels, non-dose dependent, was observed.
