The Effect of Q10 on Reducing of Induced Diabetic Kidney Tissue Injury and Improvement of the Serum Levels of Renal Functional Factors in Rat
Subject Areas : Journal of Animal Biology
1 - گروه علوم پایه، دانشکده دامپزشکی، واحد تبریز، دانشگاه آزاد اسلامی، تبریز، ایران
Keywords: Q10, nephropathy, Rat, Diabetes, Alloxan,
Abstract :
The present study was conducted to evaluate the protective effects of Q10 on the damage of kidney tissue as well as serum factor levels due to diabetes induction in Alloxan-induced diabetic rats. The experimental model of diabetes type A in rats was induced by intraperitoneally injection of 120 mg Alloxan monohydrate per kg/bw. Physiology serum was used as Alloxan solvent. Control group rats received buffer citrate 0.05 M (pH= 4.5), intraperitoneally. The Q10- treatment group received 75 mg/kg Q10 via gavage for one month. In Alloxan-Q10 treatment group, the rats at first were diabetic and then they received 75 mg/kg Q10 via gavage for one month. Severe tissue damage was observed in the obtained tissue samples from diabetic rats. The tissue damages were in the forms of acute tubular necrosis, interstitial tubular nephrosis, vacuolar alterations, and atherosclerosis. The obtained results from urea, uric acid, and creatinine levels in understudied rats demonstrated a significant difference between diabetic-treatment group and diabetic-Q10 group (p
