Effects of Lavandula officinalis Aqueous Extract on Ovaries Balb/c Adult Female Mouse

Subject Areas : Journal of Animal Biology

F. Soheili ¹ , P. Torabzadeh ² , M. Ramezani ³

1 - Department of Biology, Karaj Branch, Islamic Azad University, Karaj, Iran
2 - Department of Biology, Karaj Branch, Islamic Azad University, Karaj, Iran
3 - Department of Biology, Central Tehran Branch, Islamic Azad University, Tehran, Iran

Received: 2017-08-30 Accepted : 2017-08-30 Published : 2017-08-23

Keywords: Infertility, Mice, Follicle, Ovary, Lavendula officinalis,

Abstract :

Lavendula officinalis has sedative properties of aqueous extract. It is effective on diabetes and depression and has antimicrobial properties and manage. However, its effect on reproductive system has not been reviewed yet. Therefore, in this study, the effect of L. officinalis aqueous extract on ovaries BALB/c adult female mouse was stdied. After preparation of aqueous extract and when we observed lack of lethal symptoms, experiments were continued with selected doses as follows: 6 (group1: 15 mice), 12 (group2: 15 mice), 18 (group3:15mice) g/kg.bw. Intraperitoneally injections were done for 12 d on 65 mice. Results were compared with the control group (non-injection: 10 mice) and sham (injection of normal saline: 10 mice). For reliability, experiences were repeated 2 times. Data was checked with SPSS 20 and Duncan test and ANOVA with condition (P<0.05) and (P<0.001). The experimental groups1 and 2, showed a significant decrease in large and small diameters of ovaries (P<0.05). In experimental group3 showed a significant increase in numbers of primary follicles (P<0.05). All experimental groups showed a significant decrease of growing, Graafian follicle and corpus luteum.L. officinalis aqueous extract has detrimental effect on female ovaries and may be use as a contraceptive pill in the future.

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