Effect of Ketamine-Xylazine repetitive administration on open wound healing in rabbits- A clinical and histopathological evaluation

Subject Areas : clinical veterinary science

M. Abarkar ¹ (Department of clinical science, faculty of veterinary medicine, Karaj branch, Islamic Azad University, Karaj, Iran)
S. M Foroud ² (faculty of veterinary medicine, Karaj branch, Islamic Azad University, Karaj, Iran and faculty of veterinary medicine, Shiraz university, Shiraz, Iran)
فریبرز Moayer ³ (Department of pathobiology, faculty of veterinary medicine, Karaj branch, Islamic Azad University, Karaj, Iran)
مصطفی Darestani Farahani ⁴ ()

Received: 2016-11-11 Accepted : 2016-11-11 Published : 2012-03-20

Keywords: Rabbit, Ketamine, Xylazine, restrain, Wound,

Abstract :

Open wound medication needs repeated chemical restriction for changing bandages in small animal medicine.combination of ketamine-xylazine is one of the most popular chemical restrain agents which decreases heart and respiratory rate and increase blood glucose.no previous study was seen in literature review about systemic effects of this drug combination on wound healing.An experimental study was designed on twelve New Zealand white rabbits with spuare shape incisional wounds in the back region during the 21 day trial.rabbits were divided into two equal groups and bandage change was performed every 48 hours for both groups,one anesthetized with ketamine-xylazine combination during wound medication and other just physically restrained.heart and respiratory rate,O2 saturation of hemoglobin,and blood glucose were ,easured and recorded during each wound bandage.histopathological and macromorphological evaluations were accomplished by taking tissue sampling and photography of wounds.total wound,granulation and epithelial tissue area were measured by computer analysis for two groups as macromorphological evaluation. the data was anslyzed using SPSS(Version 16.00). heart and respiratory rates were decreased in rabbits which anesthetized during bandage change(p<0.05).but no significant difference was seen in O2 satruration of hemoglobin, and macromorphological measurmentes between the two groups.In descriptive and numerical comparisons between the groups no difference was seen in histopatological evaluation.the results of this study indicated that repeated anesthesia with ketamine-xylazine combination had no detrimental effect on wound healing.