The trend of studies by Iranian researchers in the field of simultaneous effect of aerobic exercises and natural and synthetic antioxidant supplements on liver tissue apoptosis: bibliometric analysis
Subject Areas : Physical Activity and Health
Elahe Brati Elahe Brati
1
(Department of exercise physiology, Central, Tehran Branch, Islamic Azad University, Tehran.Iran)
محمد علی آذربایجانی
2
(Department of exercise physiology, Central, Tehran Branch, Islamic Azad University, Tehran. Iran)
Shahin Riyahi Malayeri
3
(Department of exercise physiology, East, Tehran Branch, Islamic Azad University, Tehran. Iran)
maghsoud peeri
4
(department of physiology, Central Tehran Branch, Islamic Azad University, Tehran, Iran)
Hoseyn Fatolahi
5
(Department of exercise physiology, Pardis Branch, Islamic Azad University, Pardis.Iran)
Keywords: apoptosis, antioxidant supplements, aerobic exercise, bibliometric analysis,
Abstract :
The current study examines the trend of studies by Iranian researchers in the field of the simultaneous effect of aerobic exercises and natural and synthetic antioxidant supplements on liver tissue apoptosis: a bibliographic analysis. In order to carry out this study, keywords including aerobic exercise or endurance exercise and apoptosis or organized cell death and liver or hepatocyte were selected. Then these key words were entered in the database of the recipients to search for articles. Then, the obtained articles were converted with the RIS format from the database of the receivers and outputted from it and entered into the VOSviewer software for further analysis. The results showed that 55 authors published 14 articles, with an average of 3.92 ± 0.61 authors per article. Based on the organizational affiliation of the responsible author, out of 14 published articles, 11 articles were written by faculty members of Islamic Azad University (78%), 2 articles by faculty members of Mazandaran University (15%) and one article by faculty members of Shahid Chamran University of Ahvaz. 7%) has been published. Out of fourteen published articles, twelve articles (85%) have been published in the journals of medical sciences universities and two articles (15%) have been published in the journals of the Ministry of Science. The results of this study showed that both aerobic exercise and antioxidant supplements have reduced the process of liver tissue apoptosis in disease and poisoning conditions.
1-Sun M, Zhao X, Li X, Wang C, Lin L, Wang K, Sun Y, Ye W, Li H, Zhang Y, Huang C. Aerobic Exercise Ameliorates Liver Injury in Db/Db Mice by Attenuating Oxidative Stress, Apoptosis and Inflammation Through the Nrf2 and JAK2/STAT3 Signalling Pathways. J Inflamm Res. 2023 Oct 24;16:4805-4819.
2-Zou Y, Qi Z. Understanding the Role of Exercise in Nonalcoholic Fatty Liver Disease: ERS-Linked Molecular Pathways. Mediators Inflamm. 2020 Jul 25;2020:6412916.
3-Yuniartha R, Arfian N, Setyaningsih WAW, Kencana SMS, Sari DCR. Accelerated Senescence and Apoptosis in the Rat Liver during the Progression of Diabetic Complications. Malays J Med Sci. 2022 Dec;29(6):46-59.
4-Fathi R, Nasiri K, Akbari A, Ahmadi-KaniGolzar F, Farajtabar Z. Exercise protects against ethanol-induced damage in rat heart and liver through the inhibition of apoptosis and activation of Nrf2/Keap-1/HO-1 pathway. Life Sci. 2020;256:117958.
5- Hu SJ, Jiang SS, Zhang J, Luo D, Yu B, Yang LY, Zhong HH, Yang MW, Liu LY, Hong FF, Yang SL. Effects of apoptosis on liver aging. World J Clin Cases. 2019 Mar 26;7(6):691-704.
6-Egnatchik RA, Leamy AK, Jacobson DA, Shiota M, Young JD. ER calcium release promotes mitochondrial dysfunction and hepatic cell lipotoxicity in response to palmitate overload. Mol Metab. 2014 May 22;3(5):544-53.
7- Jou J, Choi SS, Diehl AM. Mechanisms of disease progression in nonalcoholic fatty liver disease. Semin Liver Dis. 2008 Nov;28(4):370-9.
8- Muro I, Qualman AC, Kovacs EJ, Idrovo JP. Burn-Induced Apoptosis in the Livers of Aged Mice Is Associated With Caspase Cleavage of Bcl-xL. J Surg Res. 2023 Oct;290:147-155.
9- Li S, Tan HY, Wang N, Zhang ZJ, Lao L, Wong CW, Feng Y. The role of oxidative stress and antioxidants in liver diseases. Int J Mol Sci. 2015;16:26087–26124.
10- Pomacu MM, Trașcă MD, Pădureanu V, Bugă AM, Andrei AM, Stănciulescu EC, Baniță IM, Rădulescu D, Pisoschi CG. Interrelation of inflammation and oxidative stress in liver cirrhosis. Exp Ther Med. 2021 Jun;21(6):602.
11- Wong VW, Wong GL, Chan RS, Shu SS, Cheung BH, Li LS, Chim AM, Chan CK, Leung JK, Chu WC, Woo J, Chan HL. Beneficial effects of lifestyle intervention in non-obese patients with non-alcoholic fatty liver disease. J Hepatol. 2018 Dec;69(6):1349-1356.
12- Li L, Liu R, Niu M, Zhou T. Effect of Aerobic Exercise on Liver Tissue in Rats with NAFLD. Biomed Res Int. 2022 Sep 10;2022:4165839.
13- Zolfagharzadeh F, Roshan VD. Pretreatment hepatoprotective effect of regular aerobic training against hepatic toxicity induced by Doxorubicin in rats. Asian Pac J Cancer Prev. 2013;14(5):2931-6.
14- Ilyas U, Katare DP, Aeri V, Naseef PP. A Review on Hepatoprotective and Immunomodulatory Herbal Plants. Pharmacogn Rev. 2016 Jan-Jun;10(19):66-70.
15- Ali M, Khan T, Fatima K, Ali QUA, Ovais M, Khalil AT, Ullah I, Raza A, Shinwari ZK, Idrees M. Selected hepatoprotective herbal medicines: Evidence from ethnomedicinal applications, animal models, and possible mechanism of actions. Phytother Res. 2018 Feb;32(2):199-215.
16- Uboh FE, Ebong PE, Umoh IB. Comparative Hepatoprotective Effect of Vitamins A and E Against Gasoline Vapor Toxicity in Male and Female Rats. Gastroenterology Res. 2009 Oct;2(5):295-302.
17- Hoseini Z, Behpour N, Hoseini R. Aerobic training with moderate or high doses of vitamin D improve liver enzymes, LXRα and PGC-1α levels in rats with T2DM. Sci Rep. 2024 Mar 17;14(1):6409.
18- Aghaei F, Wong A, Zargani M, Sarshin A, Feizolahi F, Derakhshan Z, Hashemi M, Arabzadeh E. Effects of swimming exercise combined with silymarin and vitamin C supplementation on hepatic inflammation, oxidative stress, and histopathology in elderly rats with high-fat diet-induced liver damage. Nutrition. 2023 Nov;115:112167.
19- Słomko J, Zalewska M, Niemiro W, Kujawski S, Słupski M, Januszko-Giergielewicz B, Zawadka-Kunikowska M, Newton J, Hodges L, Kubica J, Zalewski P. Evidence-Based Aerobic Exercise Training in Metabolic-Associated Fatty Liver Disease: Systematic Review with Meta-Analysis. J Clin Med. 2021 Apr 13;10(8):1659.
20- van Eck N. J., Waltman L. (2017). Citation-based clustering of publications using CitNetExplorer and VOSviewer. Scientometrics, 111(2), 1053–1070.
21- van Eck N. J., Waltman L. (2018). Manual for VOSviewer version 1.6.9. Leiden, the Netherlands: Universiteit Leiden.
22- Hamideh Tavoli, Hossein Abednatanzi, Mohammad Ali Azarbayejani,Alireza Iranbakhsh. The Effect of Aerobic Exercise and Pineapple Extract on Bax and Bcl2 Gene Expression and Bax/Bcl2 Ratio in Liver Tissue of Mice with Melanoma. Nafas,9(3) 2022,16-28.(Persian).
23-Nader Afravi, Hossein Abednatanzi , Helalizadeh Masoumeh, Mandana Gholami. Gene Expression Changes of Pro and Anti-Apoptotic Indices in Liver Tissue and Insulin Resistance Index after HIIT and Thyme Extract in Obese Type 2 Diabetic Rats, Sport Physiology, 13(52),2022, 61-84. (Persian).
24-Akram Azhandeh, Yaser Kazemzadeh , Ali Gorzi, Shahedi Valiollah, (2021). The effect of propolis and chicory consumption during eight weeks of resistance training on some indicators of liver tissue apoptosis in female mice consuming testosterone enanthate, Medical Journal of Mashhad University of Medical Sciences, 64(1), 2248-2258. (Persian).
25-Fatemeh Shayesteh Rad, Parvin Farzanegi , Masoumeh Habibian, Hadi Alinejad, (2017). The effect of regular swimming training and garlic extract on apoptosis of liver cells in doxorubicin-induced aging rat, Daneshvar Medicine, 24(129), 65-74. (Persian).
26-Solmaz Sadeghian, Yaser Kazemzadeh, Yahya Mohammadnejadpanah Kandi, Sanaz Mirzayan Shanjani, Saeed Sedaghati, (2022). The Effect of Aerobic Exercise with Curcumin Consumption on Tissue Apoptosis Indices in the Liver Tissue of Rats Induced by Breast Cancer in the Doxorubicin Treatment Phase: An Experimental Study, Journal of Rafsanjan University Of Medical Sciences, 21(4), 433-448. (Persian).
27-Amir Haj Ghasem, Parvin Farzanegi, Zohreh Mazaheri, (2019). Effects of combined therapy with resveratrol, continuous and interval exercises on apoptosis and lipid profiles in the liver of rats with nonalcoholic fatty liver disease, Koomesh, 21(3), 540-548. (Persian).
28-Hasan Delroz, Ahmad Abdi, Alireza Barari, Parvin Farzanegi, (2020). The Effect of Eight Weeks of Aerobic Training Combined With Resveratrol on MFn1 and MFn2 Expression in Cardiac Myocytes in a Non-alcoholic Fatty Liver Animal Model, Complementary Medicine Journal of faculty of Nursing & Midwifery, 9(4), 3878-3889. (Persian).
29-Sh. Mirdar Harijani, N. Musavi, Gh.R. Hamidian, H.A. Oliaei, (2014). Effect of Endurance Swimming Training and Silymarin Treatment on Changes in Liver Apoptotic Index in Pregnant Rats Exposed to Cadmium, Journal of Rafsanjan University Of Medical Sciences, 13(8), 705-714. (Persian).
30-Shadmehr Mirdar Harijani, Hossein Aliasgharzade Oliaei, Gholamreza Hamidian, Narges Musavi, (2015). The effect of swimming endurance training and silymarin supplementation during pregnancy on maternal cadmium exposure - induced apoptosis in hepatocytes of rat neonates, Journal of practical studies of Biosciences in Sport, 2(3), 9. (Persian).
31-Moradi M, Shakerian S, Nikbakht M. Effect of eight weeks of high intensity interval training and crocin consumption on the apoptotic genes expression in the liver tissue of male rats under chronic doxorubicin induction. J Birjand Univ Med Sci. 2020; 27 (4) :323-335. (Persian).
32-Esmaeil Jabbari, Mandana Gholami, Hojatollah Nikbakht, Nader Shakeri, Farshad Ghazaliyan, (2019). Effect of aerobic training and L-carnitine supplementation on some apoptotic factors in diabetic rat liver, Razi Journal of Medical Sciences, 26(7), 131-140. (Persian).
33-Mozhgan Ahmadi, Asieh Abbassi Daloii, Samira Salehi Kiasari, (2020). Response of Liver Tissue Bax and Bcl-2 Gene Expression to Aerobic Training with L-Carnitine Supplementation in Rats Toxicated by Boldenone, Complementary Medicine Journal of faculty of Nursing & Midwifery, 9(4), 3890-3901. (Persian).
34-Hamidreza Etemadi, Sajad Arshadi, Abdolali Baneifar, Mohammadali Azarbayjani, (2021). The Effect of Aerobic Exercise and Vitamin D Supplementation on Hepatic Fas and c-FLIP Levels in Rats Exposed to Oxygenated Water, Journal of Knowledge & Health, 15(4), 20-27. (Persian).
35-Etemadi H R, Arshadi S, Banaeifar A, azarbayjani M. The effect of aerobic exercise and vitamin D supplementation on hepatic Apoptosis levels in rats exposed to oxygenated water. RJMS 2021; 28 (2) :23-32. (Persian).
