Effect of Interval Training with Different Intensity on Serum Levels of Spexin and Asprosin in Women with Type II Diabetes

Subject Areas : Journal of Animal Biology

Mozhgan Baghaei-Barzabadi ¹ , Zahra Ahadi ² , Mohammad Karimi ³ , Fatemeh Akhlaghi ⁴

1 - Department of Physical Education and sport sciences, Qom University of Technology, Qom, Iran
2 - Department of Physical Education and sport sciences, Qom University of Technology, Qom, Iran
3 - Department of Physical Education and sport sciences, Qom University of Technology, Qom, Iran
4 - Department of Physical Education and sport sciences, Qom University of Technology, Qom, Iran

Received: 2024-05-22 Accepted : 2024-08-08 Published : 2025-01-12

Keywords: Diabetes, Interval training, Spexin, Asprosin.,

Abstract :

Spexin and Asprosin as multifunctional peptides, play a role in glucose metabolism. This study aimed to investigate the response of these two peptides to different intensities of interval training in women with type 2 diabetes. This study was a quasi-experimental type with a pre-test to post-test design. 30 women with type 2 diabetes, aged 30 to 40 years, were randomly divided into three equal groups (n=10) including; Control, moderate intensity interval training (MIIT), and high intensity interval training (HIIT). The training protocol consisted of 12 weeks, three sessions per week, and with intensities of 70-75% and 80-95% of maximum heart rate, respectively. Before and after exercise intervention, serum levels of spexin and asprosin were evaluated by ELISA method. Intragroup changes were analyzed using a paired t-test and intergroup changes were analyzed using a one-way analysis of variance test with Tukey's post hoc test. The significant level was considered to be p≤0.05. The results indicated that in training groups, following 12 weeks of interval training, the serum levels of spexin increased significantly (p = 0.0001) and asprosin decreased significantly (p = 0.0001). Also, the insulin resistance index showed a significant decrease (p = 0.0001). In conclusion, it seems that HIIT and MIIT exercises can cause positive changes in the amount of spexin and asprosin, along with improving insulin resistance in women with type 2 diabetes. Based on the findings of the present study, HIIT exercises have better effects than MIIT training

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