The effect of 10 weeks of aerobic exercise on nitric oxide and vascular endothelial growth factor to earobic exercise after transplantation of mesenchymal stem cells in myocardial infarction model rats.
Subject Areas : Physiology of Fitness
fatemeh kolbadinezhad
1
,
Seyed Abdollah Hashemvarzi
2
,
abdollreza jafari
3
1 -
2 - Islamic Azad University, Sari Branch
3 - Department of Physical Education, Sports Physiology, Faculty of Humanities, Azad University of Sari
Keywords: aerobic exercise, mesenchymal stem cell, nitric oxide, VEGF, myocardial infarction.,
Abstract :
Introduction and purpose: heart infarction as the most common cause of heart failure is one of the most common cardiovascular diseases and the purpose of this research is to determine the response of nitric oxide and vascular endothelial growth factor during 10 weeks of aerobic exercise after cell transplantation. Mesenchymal stem cells in heart infarction model mice.
Materials and methods: In this experimental study, 60 male Wistar rats with an age range of 7-8 weeks were used. The subjects were divided into 6 groups of 10 each. healthy group, patient control, sham, cell, exercise and cell + exercise. To cause cardiac infarction, the artery was completely blocked using 0.6 silk thread. After extracting the stem cells, about 106 cells were injected for each mouse through the vein. The exercise program consisted of running on a treadmill for 50 minutes for 5 days a week. To determine the normality of the data distribution, the Kolmogorov-Smirnov test and the one-way analysis of variance test were used for significance, and Tukey's post hoc test was used to location of the difference.
Findings: The findings of this study showed that the induction of myocardial infarction caused a significant increase in the levels of VEGF and NO in the stem cell group compared to the patient control group (p<0.001).
Conclusion: These findings show that the levels of VEGF and NO in the experimental group increased after 10 weeks of treatment with aerobic exercises and stem cells through a paracrine mechanism.
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