The Role of Plasma Chemistry Parameters in Cancer Therapy by Plasma Jet

Subject Areas : Medicinal Chemistry

Elahesadat Torabibashkani ¹ , Kiomars Yasserian ² , Majid Borghei ³ , Hamideh Mahmoodzadeh Hosseini ⁴ , Amir Hossein Sari ⁵

1 - Department of Physics, Karaj Branch, Islamic Azad University, Karaj, Iran
2 - Department of Physics, Karaj Branch, Islamic Azad University, Karaj, Iran
3 - Department of Physics, Karaj Branch, Islamic Azad University, Karaj, Iran
4 - Applied Microbiology Research Center, Biomedicine Technologies Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran
5 - Plasma Physics Research Center, Sciences and Research Branch, Islamic Azad University, Tehran, Iran

Received: 2024-02-23 Accepted : 2024-05-05 Published : 2024-12-22

Keywords: Plasma Chemistry Parameters, Atmospheric Pressure Plasma Jet, Plasma Cancer Therapy, Helium Plasma, Argon Plasma,

Abstract :

Atmospheric pressure plasma jet (APPJ) is one of the efficient methods to treat cancer cells. It is known that by setting the plasma parameters such as plasma density and temperature by variation of applied voltage on the plasma jet device, the plasma can induce apoptosis in cancer cells and reduce tumor growth without significant influence on healthy cells. To gain deeper insights into the influence of voltage variations and the type of working gas, a simulation of APPJ was conducted using Comsol Multiphysics software. To complete the simulation, various chemical features were considered, such as surface reactions, elastic collision cross-sections, and ionization and excitation cross-sections, which depend on the plasma energy. The dependence of the plasma temperature and density on the applied voltage and types of working gas was also investigated. It was found that higher voltage results in an increase in the plasma temperature and electron density. As the input voltage increased, both the plasma pressure and its spatial nonuniformity within the plasma tube showed a noticeable rise. In addition, the overall values of the electric potential for gas working of He is higher than the argon gas.