Study of the ketoprofen and phenylbutazone effects in the healing process of experimental rabbit bone defect based on radiology and histopathology findings
Subject Areas : Journal of Comparative PathobiologyُSamasadat Rezaii 1 , ُُSiamak Alizadeh 2 , Mohammadreza Hosseinchi 3
1 - D.V.M. Graduate, Faculty of Meterinary Medicine, Urmia Branch, Islamic Azad University, Urmia, Iran.
2 - Department of Clinical Sciences, Faculty of veterinary medicine, Naghadeh Branch, Islamic Azad University, Naghadeh, Ir
3 - Department of Basic Sciences, Faculty of veterinary medicine, Urmia Branch, Islamic Azad University, Urmia, Iran.
Keywords: Experimental deficiency, Histopathology, Ketoprofen, Phenylbutazone, Rabbit. ,
Abstract :
Non-steroidal anti-inflammatory drugs such as ketoprofen and phenylbutazone are common drugs for pain management during and after surgery in humans and animals. The current study aimed to evaluate the effects of these two drugs on the normal healing process of rabbit radius bone following the experimental defect. In this cross-sectional descriptive study used 15 New Zealand white male rabbits in the control, ketoprofen and phenylbutazone groups. Following anesthetization of the animal, a defect with a diameter and depth of 3 mm was created in its right radius. Defect healing was evaluated by preparing histopathology samples and taking radiographs on days 7, 14, 21, 35 and 42. According to the results of this study, the beginning of the process of filling the defect in the control and ketoprofen groups was on the 14th day and in the phenylbutazone group on the 21st day after surgery. The amount of callus formation in the control group on day 35 was significantly higher than days 14 and 21 (p≤0.05), while no significant difference was observed in other groups. On days 14 and 21, in terms of callus formation and defect filling, the ketoprofen group had a higher mean score than the phenylbutazone group. This average score in the phenylbutazone group on day 35 was more than the ketoprofen group, and after that this ratio was higher in the ketoprofen group until the end of the study. This study showed that ketoprofen was less effective in delaying bone healing than phenylbutazone.
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