Evaluation of the clinical, analgesic and Sedative Effects of tramadol with acepromazine in the Horse
Subject Areas : Journal of Comparative Pathobiology
Fadaeifar, R., Asghari, A., Ozmaie, S., Sakha, M. .
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Keywords: Tramadol, Acepromazine, Analgesia, Sedation, Horse,
Abstract :
A variety of analgesic and sedative agents are available, and which one can be used in horses is a highly controversial issue. The purpose of this study was to evaluate the analgesic and sedative effects and effect on vital signs and probable side effects of administered tramadol with acepromazine in the horse. Ten healthy mix breed horses 2-10 years of age, weighing 250-350 kg were randomly divided into two groups. One group received combination of tramadol (1 mg/kg, IV) and acepromazine (0/05 mg/kg, IV). The second control group received a saline placebo (1ml/45 kg bwt, IV). Heart rate, respiratory rate rectal temperature, systolic and diastolic blood pressure and GI movement were recorded. The records were averaged for the fifteen minutes’ intervals to 6 hours after injection. Analgesia was assessed with pin prick in the tail and perineal region. Data were analyzed statistically by two way of analysis of variance (ANOVA) using repeated measurements and Duncan’s multiple range tests to determine significant differences using P<0.05. In this study tramadol with acepromazine show good sedation but have no analgesic effects. The mean of temperature degree, respiratory rate, heart rate, systolic and diastolic blood pressure and GI movement in the treatment group at the time of 0, 15, 30, 60 and 360 minute did not show significant difference with the control group. Results of this study showed that parenteral administration of tramadol with acepromazine is fast and effective sedation in animals are created and no significant changes in vital signs and does not cause any danger to the animal although it does not reduce pain.
