Effect of Hydro-Ethanolic Extract of Currant on Amount of Anxiety in Adult Male Mice in Plus Maze Model
Subject Areas :Seyyed Ebrahim Hosseini 1 , Yasaman Avazpour 2
1 - گروه زیستشناسی، دانشکده علوم، واحد شیراز، دانشگاه آزاد اسلامی، شیراز. ایران
2 - گروه زیستشناسی، دانشکده علوم، واحد شیراز، دانشگاه آزاد اسلامی، شیراز. ایران
Keywords: Anxiety, Currant, elevated plus maze, Mice,
Abstract :
Inroduction & Objective: Anxiety is one of the most widespread psychological disorders which may lead to functional disorders, chronic diseases and decrease in life style. Considering the side effects caused by chemical drugs, this study was carried out to investigate the effect of hydro-ethanolic extract of currant on amount of stress in adult male mice with the goal of finding a safer way for managing stress.Material and Methods:In this experimental study 40 adult male mice were used falling into 5 groups including: Control (no treatment), Sham (consuming distilled water), and 3 experimental groups (gavaged with three concentrations of hydro-ethanolic extract of currant (200, 100, 400 mg/kg)). The level anxiety was measured by elevated plus maze. The duration and number of presence of each mouse in closed and open arms were determined. The results were analyzed using ANOVA test with Tukey post hoc.Results: Results showed that hydro-ethanolic extract of currant at doses of 100 , 200 and 400 mg/kgBW caused a significant reduction in anxiety.Conclusions:According to the findings, it appears that the extract of currant with flavonoids compounds as GABA receptor agonists and increase serotonin may reduce anxiety in elevated plus maze
