The Effect of Glyphosate Herbicide on Oogenesis and Ovary in Adult Rats
Subject Areas :Parivash Karimi 1 , Habib allah jowhary 2 , Vahid Hemayatkhah Jahromi 3 , Esmaiel Fattahi 4
1 - کارشناسی ارشد گروه زیست شناسی، واحد جهرم، دانشگاه آزاد اسلامی، جهرم. ایران.
2 - استادیار گروه زیست شناسی، واحد داراب، دانشگاه آزاد اسلامی، داراب. ایران.
3 - استادیار گروه زیست شناسی ، واحد جهرم، دانشگاه آزاد اسلامی، جهرم. ایران.
4 - گروه زیست شناسی ، واحد آیت الله آملی، دانشگاه آزاد اسلامی، آمل. ایران.
Keywords: Oogenesis, Ovary, Rat, Glyphosate,
Abstract :
Inroduction & Objective:Glyphosate, commercial known as Roundup is a herbicide from phosphonic family (Amine isopropyl salt) which is used as a systemic toxic for controlling all kinds of annual or perennial weed plants. The goal of this study is the effect of glyphosate herbicide on oogenesis and ovary in adult ratsMethods50 female matured rats (Wistar race) with mean weight200±15were prepared and divided into five 10 members groups including control, sham, experimental 1, experimental 2 and experimental 3. The control group didn’t receive any treatments. The sham group has received 0.2 cc distilled water as daily qualities injection and the 1, 2 and 3 groups have received 50,100 and 200 mg/kg glyphosate as intra peritoneum injection during 14 consecutive days. Ovaries were extracted and sliced, tissue sections were studying on the number of secondary follicles, Graffian follicles, corpus luteum and atretic follicles.ResultsThe results of this research showed that nevertheless glyphosate had not significant influence on ovary weight but the secondary, Graffian and atretic follicles and corpus leuteum of experimental groups had significant increase than the control group (pConclusionIt can be concluded that glyphosate can change ovary follicles amount and oogenesis in rats
