Effects of Silymarin in Experimental Inflammatory Pain Induced by Formalin and Relation with Histaminergic System

Subject Areas :

Mitra Gholizade Nikpey1 ¹ , Ali Mojtahedin ² , Reza Seyedsharifi ³

1 - دانش آموخته کارشناسی ارشد فیزیولوژی دام دانشگاه محقق اردبیلی، اردبیل، ایران.
2 - بخش فیزیولوژی، دانشکده کشاورزی و منابع طبیعی مغان، دانشگاه محقق اردبیلی، اردبیل، ایران
3 - گروه علوم دامی، دانشکده کشاورزی و منابع طبیعی، دانشگاه محقق اردبیلی، اردبیل، ایران.

Received: 2017-02-20 Accepted : 2018-08-04 Published : 2016-04-20

Keywords: silymarin, Histaminergic system, Inflammatory pain, Ranitidine,

Abstract :

Inroduction & Objective: The most common pain complaint of patients is one of the oldest forms of human problems.According to the therapeutic effects of medicinal plants,the effects of silymarin, an active ingredient of the Milk thistle, in an experimental model of inflammatory pain induced by formalin and examined its relationship with the histaminergic system.Material and Methods:In this study, 42 male Wistar rats were used.Animals were divided into 7 groups in  each group 6 rats as follows: Group 1(Control): Normal Saline (i.p)+Formalin 1% (intraplantar), Group 2,3,4 and 5 Silymarin (50,100,200 and 400mg/kg, ip) respectively + Formalin 1%, Group 6: Ranitidine (20mg/kg, i.p) + Formalin 1%, Group 7: Ranitidine (20mg/kg, i.p) + Silymarin (200mg/kg, i.p) + Formalin 1%.Results: The results showed that intraplantar injection of formalin 1% significantly (PConclusion:The results revealed that silymarin produced antinociception effect in formalin induced pain and this effect probably will be down by interfering with the H2 histamine receptors.