The Effect of Sertraline on Pituitary–Testis Hormones and Spermatogenesis in Rat

Subject Areas :

لاله پاشا ¹ (دانشجوی دکتری فیزیولوژی جانوری، گروه زیست شناسی، واحدکازرون، دانشگاه آزاداسلامی، کازرون. ایران.)
مختار مختاری ² (استاد فیزیولوژی، گروه زیست شناسی واحد کازرون، دانشگاه آزاد اسلامی، کازرون. ایران)
سعید خاتم ساز ³ (دانشیار فیزیولوژی گروه زیست شناسی، واحد کازرون، دانشگاه آزاداسلامی، کازرون، ایران.)
مهرداد شریعتی ⁴ (دانشیار زیست شناسی سلولی وتکوین، گروه زیست شناسی، واحد کازرون، دانشگاه آزاد اسلامی، کازرون، ایران.)

Received: 2018-03-06 Accepted : 2018-08-04 Published : 2018-01-21

Keywords: Dihydrotestosterone, LH, Testosterone, Rat, FSH, Sertraline, Testis,

Abstract :

v:* {behavior:url(#default#VML);} o:* {behavior:url(#default#VML);} w:* {behavior:url(#default#VML);} .shape {behavior:url(#default#VML);} >1024x768Normal0falsefalsefalseEN-USX-NONEAR-SA /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-qformat:yes; mso-style-parent:""; mso-padding-alt:0in 5.4pt 0in 5.4pt; mso-para-margin:0in; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:11.0pt; font-family:"Calibri","sans-serif"; mso-ascii-font-family:Calibri; mso-ascii-theme-font:minor-latin; mso-fareast-font-family:"Times New Roman"; mso-fareast-theme-font:minor-fareast; mso-hansi-font-family:Calibri; mso-hansi-theme-font:minor-latin; mso-bidi-font-family:Arial; mso-bidi-theme-font:minor-bidi;} >Inroduction & Objective:Sertraline is one of the most widely used antidepressant drug;however ,it has some side effect on different parts of body like endocrine axis.the research have studied the effect of sertraline on the concentration of LH, FSH,Testosterone and Dihydrotetosterone and testicular tissue changes.Material and Methods:In This experimental study 40 adult male rats of wistar were divided in to 4 groups of ten: The control group received normal diet,shame group took group received normal saline as a solvent and experimental groups, received 10, 50 mg per kg body weight serteraline. At the end of 21th days, blood samples and levels of FSH, LH, testosterone and dihydrotestosterone were measured. also preparation of tissue sections of testis tissue. The collected data were analyzed by the SPSS software using ANOVA and t-test.Results: The levels of LH, FSH, Testosterone ,and Dihydrotestosterone in the experimental groups receiving 50, 10 mg/kg Sertraline was significantly decrease compared to the control and sham groups(PConclusion: Sertraline causes male sexual imblances by changing in LH,FSH,testosterone and dihydrotestosterone hormone concentration.