The effects of passive inhalation of cigarette smoke on serum lipid profile in the rat

Subject Areas : Veterinary Clinical Pathology

جعفر Rahmani Kahnamoei ¹

1 - Assistant Professor, Department of Clinical Science, Tabriz Branch, Islamic Azad University, Tabriz, Iran.

Received: 2016-07-15 Accepted : 2016-10-26 Published : 2016-11-21

Keywords: Rat, Cigarette, Passive smoking, Serum lipid profiles,

Abstract :

Passive cigarette smoke contains five times more carbon monoxide and six times more nicotine compared to the main smoke because cigarette filter has a protective role for smokers. Cigarette smoke contains a range of oxidants and free radicals that can directly or indirectly induce oxidative stress in the body. Adding some aromatic ingredients to cigarette may play an important role in increasing damage and free radicals. The aim of this study was to evaluate the effects of passive inhalation of cigarette smoke on serum lipid profile in rats. For this purpose, 16 male Wistar rats were divided randomly into two groups of eight rats, control and treatment. There was no intervention in the control group, but treatment group was exposed to a cigarette passive smoke on a daily basis for a month. After a month, the rat tail vein blood samples were taken and after separation of the sera, serum lipid profiles, including triglycerides, total cholesterol, LDL and HDL was measured and the results were statistically analyzed using t-test. There was a significant (p<0.01) difference between the two groups regarding the serum levels of LDL but no other significant differences were observed. The results showed that cigarette smoke causes an increase in serum LDL, which is considered one of the risk factors for cardiovascular diseases.

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