Post surgical adhesion prevention: Vitamin C or Satureja Khuzestanica

Subject Areas : Veterinary Clinical Pathology

ayda najafian ¹ (متخصص زنان و زایمان، مرکز باروری و ناباروری خلیج فارس، استادیار دانشگاه علوم پزشکی هرمزگان، بندرعباس، ایران.)
azin alavi ² (استادیار دپارتمان بیولوژی دریایی، هیت علمی دانشگاه هرمزگان، بندرعباس، ایران.)
kambiz amjadigolpayegani ³ (دامپزشک، اداره کل دامپزشکی هرمزگان، بندرعباس، ایران.)
sakineh dadipour ⁴ (دانشجوی کارشناسی ارشد، کمیته تحقیقات دانشجویی هرمزگان، بندرعباس، ایران.)
ali safarimoradabadi ⁵ (دانشجوی کارشناسی ارشد، کمیته تحقیقات دانشجویی هرمزگان، بندرعباس، ایران.)
soghra fallahi ⁶ (دانشجوی دکترای تخصصی پژوهشی پزشکی مولکولی، مرکز تحقیقات پزشکی مولکولی، دانشگاه علوم پزشکی هرمزگان، بندرعباس، ایران.)
azita faramarzi ⁷ (دانشجوی دکترای بیولوژی باروری، مرکز تحقیقات درمانی و پژوهشی ناباروری، دانشگاه علوم پزشکی یزد، یزد، ایران.)

Received: 2013-06-17 Accepted : 2013-10-20 Published : 2013-05-22

Keywords: vitamin C, Satureja Khuzestanica, Abdominal Adhesions, Female Rat,

Abstract :

Abstract    Abdominal surgeries can result in intra abdominal adhesions. Since Satureja Khuzestanica is used for its anti oxidant, anti lipid, anti inflammatory and anti bacterial effects, it might also play a role in preventing intra abdominal adhesion. Therefore, this study was conducted in order to assess the effects of this plant compared with vitamin C in the prevention of post surgical intra abdominal adhesions.Forty rats were used for this experimental study and were randomly allocated into 4 groups of 10 rats. Ten ml of 0.9% normal saline, 250 mg/kg vitamin C, 250 mg/kg Satureja Khuzestanica, and both vitamin C plus Satureja Khuzestanica were used for the first, second, third and fourth group, respectively. Mazuji classification and pathology assessment were used to grade the amount of adhesion. According to our findings, vitamin C in addition to Satureja Khuzestanica is effective in preventing abdominal adhesions.

References:

• ·   زرگری، ع. (1371). گیاهان دارویی. چاپ ششم، جلد سوم، نشر دانشگاه تهران. تهران، صفحات: 441-427.

 

• Abad, M.A.J., Bermejo, P., Gonzales, E., Iglesias, I., Irurzun, A. and Carrasco, L. (1999). Antiviral activity of Bolivian plant extracts. General Pharmacology: The Vascular System, 32(4): 499-503.


• Amanlou, M., Dadkhah, F., Salehnia, A., Farsam, H. and Dehpour, A.R. (2005). An anti-inflammatory and anti-nociceptive effects of hydroalcoholic extract of Satureja khuzistanica Jamzad extract. Journal of Pharmacy & Pharmaceutical Sciences, 8(1): 102-106.


• Asadi, I., Khakpour, S., Borzoie, M., Mahmudi, F. and Fallahi, S. (2013). Matricaria Chamomile: Prevention of Abdominal Adhesions. International Electronic Journal of Medicine, 2(1): 3-10.


• Becker, J.M. and Stucchi, A.F. (2004). Intra-abdominal adhesion prevention: are we getting any closer? Annals of Surgery, 240(2): 202.


• Carty, J.L., Bevan, R., Waller, H., Mistry, N., Cooke, M., Lunec, J., et al. (2000). The effects of vitamin C supplementation on protein oxidation in healthy volunteers. Biochemical and Biophysical Research Communications, 273(2): 729-735.


• Ersoy, E., Ozturk, V., Yazgan, A., Ozdogan, M. and Gundogdu, H. (2009). Comparison of the two types of bioresorbable barriers to prevent intra-abdominal adhesions in rats. Journal of Gastrointestinal Surgery, 13(2): 282-286.


• Farsam, H., Amanlou, M., Radpour, M., Salehinia, A. and Shafiee, A. (2004). Composition of the essential oils of wild and cultivated Satureja khuzistanica Jamzad from Iran. Flavour and Fragrance Journal, 19(4): 308-310.


• Haeri, S., Minaie, B., Amin, G., Nikfar, S., Khorasani, R., Esmaily, H., et al. (2006). Effect of Satureja khuzestanica essential oil on male rat fertility. Fitoterapia, 77(7): 495-499.


• Hajhashemi, V., Ghannadi, A. and Pezeshkian, S.K. (2002). Antinociceptive and anti-inflammatory effects of Satureja hortensis L. extracts and essential oil. Journal of Ethnopharmacology, 82(2): 83-87.


• Hooker, G.D., Taylor, B.M. and Driman, D.K. (1999). Prevention of adhesion formation with use of sodium hyaluronate-based bioresorbable membrane in a rat model of ventral hernia repair with polypropylene mesh-A randomized, controlled study. Surgery, 125(2): 211-216.


• Kocak, I., Unlu, C., Akçan, Y. and Yakin, K. (1999). Reduction of adhesion formation with cross-linked hyaluronic acid after peritoneal surgery in rats. Fertility and Sterility, 72(5): 873-878.


• Mazuji, M., Kalambaheti, K. and Pawar, B. (1964). Prevention of adhesions with polyvinylpyrrolidone: Preliminary report. Archives of Surgery, 89(6): 1011.


• Menzies, D. (1992). Peritoneal adhesions. Incidence, cause, and prevention. Surgery Annual 24: 27.


• Menzies, D. (1993). Postoperative adhesions: their treatment and relevance in clinical practice. Annals of the Royal College of Surgeons of England, 75(3): 147.


• Menzies, D. and Ellis, H. (1990). Intestinal obstruction from adhesions--how big is the problem? Annals of the Royal College of Surgeons of England, 72(1): 60.


• Portz, D., Elkins, T., White, R., Warren, J., Adadevoh, S. and Randolph, J. (1991). Oxygen free radicals and pelvic adhesion formation: I. Blocking oxygen free radical toxicity to prevent adhesion formation in an endometriosis model. International Journal of Fertility, 36(1): 39.


• Quintans-Junior, L.J., Guimaraes, A.G., Santana, M.T., Araujo, B.E., Moreira, F.V., Bonjardim, L.R., et al. (2011). Citral reduces nociceptive and inflammatory response in rodents. Revista Brasileira de Farmacognosia, 21(3): 497-502.


• Rehman, A., Collis, C.S., Yang, M., Kelly, M., Diplock, A.T., Halliwell, B., et al. (1998). The effects of iron and vitamin C co-supplementation on oxidative damage to DNA in healthy volunteers. Biochemical and Biophysical Research Communications, 246(1): 293-298.


• Tulandi, T., Hum, H.S. and Gelfand, M.M. (1988). Closure of laparotomy incisions with or without peritoneal suturing and second-look laparoscopy. American Journal of Obstetrics & Gynecology, 158 (3 Pt 1): 536-537.