The Effect of Swimming Training and Trans-cinnamic Acid on Anxiety, Working Memory and Dark Neuron Density of Rat’s Offspring Hippocampus in Prenatal Seizure Model
Subject Areas : Open Access
Mohammad Ali Zarei
1
(Department of Biology, College of Sciences, Shiraz Branch, Islamic Azad University, Shiraz, Iran)
Seyed Ebrahim Hosseini
2
(Department of Biology, College of Sciences, Shiraz Branch, Islamic Azad University, Shiraz, Iran)
Mohammad Amin Edalatmanesh
3
(Department of Biology, College of Sciences, Shiraz Branch, Islamic Azad University, Shiraz, Iran)
Keywords: pregnancy, Swimming, Seizure, Hippocampus, trans-Cinnamic acid,
Abstract :
Introduction: Perinatal seizure cause hippocampal neuronal apoptosis by inducing oxidative stress in the fetal central nervous system. This study evaluates the effect of swimming training (ST) and trans-cinnamic acid (CIN) administration during pregnancy on anxiety, cell damage and density of apoptic neurons in the neonatal hippocampus following penthylentetrazol (PTZ)-induced perinatal seizures. Materials and methods: In this experimental study, neonates from 25 Wistar pregnant rats were randomly divided into 5 healthy control, PTZ+NS, PTZ+CIN, PTZ+ST and PTZ+CIN+ST groups. From embryonic day (ED) 14, the animals were treated with repeated PTZ administration (50 mg / kg, intra- peritoneally) for 5 consecutive days. During pregnancy, moderate intensity swimming (20 min, 3 sessions per week) and CIN gavage (100 mg/kg) were performed daily until term delivery. Anxiety-like behaviors and working memory were assessed with elevated plus maze and Y maze, respectively and dark neurons density was measured in the hippocampus of male neonate at postnatal day (PND) 30. Findings: Significant decrease in alteration behavior and increase in anxiety with high density of dark neuron in different areas of hippocampus were observed in the PTZ+NS group compared to the control group (p ˂ 0.05). On the other hand, in PTZ+CIN+ST group, in comparison with PTZ+NS group, a decrease in anxiety, amelioration of working memory deficit and a decrease in hippocampal dark neuron density were observed (p ˂ 0.05). Conclusion: Interaction of swimming training with trans-cinnamic acid administration ameliorates cognitive-behavioral deficits and cell damage in the hippocampus of rats exposed to maternal seizures.
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