The effect of eight weeks of resistance training after transplantation of stem cells derived from adipose tissue on some apoptotic and anti-apoptotic factors of heart tissue in non-alcoholic fatty liver model rats
Subject Areas : Effect of Physical Activity on DiseasesErfan Gholami 1 , Seyed Abdollah Hashemvarzi 2 , Seyedeh Yasaman Asadi 3
1 - Ph.D Candidate in Exercise Physiology, Department of Exercise Physiology, Faculty of Humanities, Sari Branch, Islamic Azad University, Sari, Iran
2 - Department of Sports Physiology, Sari Branch, Islamic Azad University, Sari, Iran
3 - Assistant Professor of physical education Department, Faculty of Humanities, Sari Branch, Islamic Azad University, Sari, Iran
Keywords: Resistance training, Stem cell, Apoptosis , Non-alcoholic fatty liver,
Abstract :
Introduction: Nonalcoholic fatty liver disease is one of the most common chronic hepatic diseases which may be associated with cardiovascular disease. The study was conducted with the aim of investigating the effect of eight weeks of resistance training after stem cell transplantation in fatty liver model rats. Methods: 36 rats were divided into two groups: control (6 rats) and patients with fatty liver (30 rats). The control group used standard food for 6 weeks, while the animals in the diseased groups used high-fat food to induce fatty liver disease. At the end of the sixth week, to confirm the development of fatty liver disease, blood was randomly drawn from the tails of 3 rats. Then the animals of the patient group were randomly divided into 5 groups Saline, Fatty liver, Exercise, Cell, Exercise + Cell. About 1.5 x 106 stem cells for each mouse were injected into the cell receiving groups through the tail vein. The training program consisted of 8 weeks of climbing the ladder. Results: The amounts of Bax and Bcl-2 of the heart tissue decreased and increased respectively in the treated groups compared to the patient group, but these changes were significant only in the exercise group and exercise + cells compared to the patient group. Conclusion: Non-alcoholic fatty liver disease is significantly associated with cardiac cell apoptosis. Resistance training after stem cell transplantation decreased the Bax and increased the Bcl-2 in heart tissue. Therefore, it seems that this method can be considered as a therapeutic solution.
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