The effect of continuous training with and without caloric restriction on the of tau and amyloid beta gene expressions in aged male rats brain tissue
Subject Areas : Role of Genes in Health
Hourie karimi
1
,
Mahtab Moazzami
2
,
Ali Yaghoubi
3
1 - Ph.D student of Exercise Physiology, Department of Physical Education and Exercise Science, Bojnourd Branch, Islamic Azad University, Bojnourd, Iran.
2 - Department of Exercise Physiology, Faculty of Sport Sciences, Ferdowsi University of Mashhad, Mashhad, Iran
3 - Department of Physical Education and Exercise Science, Bojnourd Branch, Islamic Azad University, Bojnourd, Iran.
Keywords: Aging, Tau gene, Beta amyloid gene, Continuous exercise, Calorie restriction,
Abstract :
Background and Purpose: Alzheimer's disease, as the most common age-related neurodegenerative disease that Amyloid plaques and interneuron filamentous coils are the two main symptoms of Alzheimer's disease, which are usually associated with amyloid angiopathy in the brain. Materials and methods: 36 old male mice were randomly divided into four control groups, continuous training group and continuous training group with restriction and calorie restriction group according to the entry criteria (same food, homogeneity in terms of age and weight, and same maintenance conditions). Mice participated in 5 sessions (6 weeks, a total of 30 sessions) or 4 sessions per week (8 weeks, a total of 28 sessions) of 60 minutes for eight weeks. Calorie restriction after examining the nutrition of mice for two weeks, between 25 and 30% of the daily calorie consumption of mice is reduced, and calorie restriction is applied in this way. The measurement of blood indices and body composition was done before and after the implementation of the training protocol. Data analysis was performed using the U-Man-Whitney test at a significant level. Results: Our results showed that there is no significant difference between the 4 investigated groups in the expression of tau gene and amyloid beta gene in old male mice with Alzheimer's disease. Conclusion: According to the factors obtained from the study, it seems that continuous training with and without caloric restriction has not been able to change the expression of tau gene and amyloid beta gene in old male rats.
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