An efficient and convenient synthesis of quinazoline derivatives catalyzed by cyanuric chloride in water
محورهای موضوعی : Iranian Journal of CatalysisMahshid Hossaini 1 , Reza Heydari 2 , Malek Taher Maghsoodlou 3
1 - Department of Chemistry, the University of Sistan and Baluchestan, P.O. Box 98135-674, Zahedan, Iran.
2 - Department of Chemistry, the University of Sistan and Baluchestan, P.O. Box 98135-674, Zahedan, Iran.
3 - Department of Chemistry, the University of Sistan and Baluchestan, P.O. Box 98135-674, Zahedan, Iran.
کلید واژه: Water, green chemistry, Aldehyde, Cyanuric Chloride, Organo-catalyst, Quinazoline,
چکیده مقاله :
In this work, an eco-friendly procedure for the preparation of 2,3-dihydroquinazoline-4(1H)-ones was developed by condensation reaction of benzylic and heterocyclic aldehydes with 2-aminobenzamide in the presence of catalytic amounts of cyanuric chloride (2,4,6-trichloro-1,3,5-triazin) as an available and inexpensive organo-catalyst under aqueous media as a green conditions. The new compounds characterized by IR, 1HNMR, 13CNMR, Mass spectrometry, and CHN elemental analysis. Excellent yield, clean reaction media, simple workup and easy purification are advantages of this methodology.
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