Anatomo-Pathological Consequences of Mycotoxins Contamination in Rabbits Feed
محورهای موضوعی : Camelآ. تینلی 1 , جی. پسانتینو 2 , آ. پریلو 3 , ن. زیزو 4
1 - Department of Veterinary Medicine, Section of Veterinary Pathology and Comparative Oncology, University of Bari “Aldo Moro”, 70010 Valenzano, Bari, Italy
2 - Department of Veterinary Medicine, Section of Veterinary Pathology and Comparative Oncology, University of Bari “Aldo Moro”, 70010 Valenzano, Bari, Italy
3 - Department of Veterinary Medicine, Section of Veterinary Pathology and Comparative Oncology, University of Bari “Aldo Moro”, 70010 Valenzano, Bari, Italy
4 - Department of Veterinary Medicine, Section of Veterinary Pathology and Comparative Oncology, University of Bari “Aldo Moro”, 70010 Valenzano, Bari, Italy
کلید واژه: mycotoxins, feed, pathological lesions, rabbits,
چکیده مقاله :
Mycotoxins are secondary metabolites produced by certain filamentous microscopic fungi, which occur naturally in the environment and may persist in animal feed. A mycotoxin contaminated diet may lead to feed refusal, poor feed conversion, diminished body weight gain and causes pathological effects associated with gross and histological changes, which are responsible for great economical losses. The present review summarizes the pathological lesions caused by the most widespread mycotoxins, aflatoxins, ochratoxins and their interaction, potentially hazardous ingredients of rabbit feed.
Abdelhamid A.M., El-Shawaf I., El-Ayoty S.A., Ali M.M. and Gamil T. (1990). Effect of low level of dietary aflatoxins on Baladi rabbits. Arch. Tierenahr. 45, 517-537.
Abdel-Wahhab M.A., Nada S.A. and Arbid M.S. (1999). Ochratoxicosis: Prevention of developmental toxicity by l-methionine in rats. J. Appl. Toxicol. 19, 7-12.
Adebajo L.O. (1993). Survey of aflatoxins and ochratoxin A in store tubers of Cyperus esculantus. Mycopathologia. 124, 41-46.
Agag B.I. (2004). Mycotoxins in foods and feeds: Aflatoxins. Ass. Univ Bull. Environ Res. 7, 173-191.
Ahmed K., El Mahady M.M., Badawy S.A., Ahmed Y.F. and Aly M.A. (2012). Pathological consequences of aflatoxins in male rabbit: cellular, genetic and oxidative damage. Glob. Vet. 8, 721-731.
Akbarsha M.A., Averal H.I., Girija R., Anandhi S. and Faridha B.A. (2000). Male reproductive toxicity of vincristine: Ultrastructural changes in the epididymal epithelial apical cell. Cytobios. 102, 85-93.
Arora R.G. and Fr¨ol´en H. (1981). Interference of mycotoxins with prenatal development of the mouse. II. Ochratoxin A induced teratogenic effects in relation to the dose and stage of gestation. Acta Vet. Scandinavica. 22, 534-552.
Aziz N.H., El-Aziz A.M.A. and Omran R.M.A. (1995). Effects of T-2 mycotoxin on histopathological changes in rabbits. Biomed. Lett. 51, 271-281.
Baker D.C. and Greene R.A. (1987). Coagulation defects of aflatoxin induced rabbits. Vet. Pathol. 24, 62-70.
Bbosa G.S., Kytia D., Lubega A., Ogwal-Okeng J., Anokbonggo W.W. and Kyegombe D.B. (2013). Review of the biological and health effects of aflatoxins on body organs and body systems Pp. in Aflatoxins - Recent Advances and Future Prospects, M. Razzaghi-Abyaneh, Ed. Intech Construction Inc., Philadelphia, USA.
Bennett J.W. and Klich M. (2003). Mycotoxins. Clin. Microbiol. Rev. 16, 497-516.
Bryden W.L. (2012). Mycotoxin contamination of the feed supply chain: Implications for animal productivity and feed security. Anim. Feed Sci. Technol. 173, 134-150.
Brown M.H., Szczech G.M. and Purmalis B.P. (1976). Teratogenic and toxic effects of ochratoxin A in rats. Toxicol. Appl. Pharmacol. 37, 331-337.
Cannon M., Cranston W.I., Hellon R.F. and Townsend Y. (1982). Inhibition, by trichothecene antibiotics, of brain protein synthesis and fever in rabbits. J. Physiol. 322, 447-455.
Cardona T.D., LLangantileke S.G. and Noomhorm A. (1991). Aflatoxin research on grain in Asia: its problems and possible solutions. Pp. 309-322 in Mycotoxin Prevention and Control in Foodgrains. R.L. Semple, A.S. Frio, P.A. Hicks and J.V. Lozare, Eds. FAO, Bangkok, Thailand.
Churamani C.P., Chattopadhyay S.K., Pawaiya R.S. and Johri T.S. (1995). Patho-anatomical studies on cumulative aflatoxicosis induced with low dose in rabbits. Indian J. Vet. Pathol. 19, 119-122.
Clark J.D., Jain A.V. and Hatch R.C. (1980). Experimentally induced chronic aflatoxicosis in rabbits. Am. J. Vet. Res. 41, 1841-1845.
Cortés G., Carvajal M., Méndez-Ramírez I., Ávila-González E., Chilpa-Galván N., Castillo-Urueta P. and Flores C.M. (2010). Identification and quantification of aflatoxins and aflatoxicol from poultry feed and their recovery poultry litter. Poult. Sci. 89, 993-1001.
Coulombe R.A..Jr., Wilson D.W., Hsieh D.P.H., Plopper C.G. and Serabjit-Singh C.J. (1986). Metabolism of aflatoxin B1 in the upper airways of the rabbit: Role of the nonciliated tracheal epithelial cell. Cancer Res. 46, 4091-4096.
Coulombe R.A.Jr. (1994). Nonhepatic disposition and effects of aflatoxin B1. Pp. 89-101 in The Toxicology of Aflatoxins: Human Health, Veterinary and Agricultural significance. D. Eaton and J. Groopman, Eds. Academic Press, USA.
Council on Agricultural Science and Technology (CAST) Report. (1989). Mycotoxins: Economics and Health Risks. Task Force Report No. 116, Ames, Iowa, USA.
Council on Agricultural Science and Technology (CAST) Report. (2003). Mycotoxins: Risks in plant, animal, and human systems. Task Force Report No. 139, Ames, Iowa, USA.
Daniels J.M., Liu L., Stewart R.K. and Massey T.E. (1990). Biotransformation of aflatoxin B1 in rabbit lung and liver microsomes. Carcinogenesis. 11, 823-827.
Doerr J.A. and Huff W.E. (1981). Effect of young broiler chickens of combining low levels of dietary aflatoxin and ochratoxin A. Poult. Sci. 60, 1648-1660.
Dwivedi P. and Burns R.B. (1985). Immunosuppressive effects of ochratoxins A in young turkeys. Avian Pathol. 14, 213-221.
Dwivedi P. and Burns R.B. (1986). The natural occurrence of ochratoxin A and its effects in poultry. A review. Part I: epidemiology and toxicology. World’s Poult. Sci. J. 42, 32-42.
Dwivedi P., Sharma A.K. and Telang A.G. (2004). NATP-CGP Project on Ochratoxicosis in Animals with Special Reference to Teratogenicity, Diagnosis and Ameliorative Measures. Annual Report Division of Pathology, IVRI, Izatnagar, New Delhi, India.
Egbunike G.N. and Ikegwuonu F.L. (1984). Effect of aflatoxicosis on acetyl- cholinesterase activity in the brain and adenohypophysis of the male rat. Neurosci. Lett. 52, 171-174.
El-Nahla S., Imam H., Moussa E., Ibrahim A. and Ghanam A. (2013). Teratogenic effects of aflatoxin in rabbits (Oryctolagus cuniculus). J. Vet. Anat. 6, 67-85.
Essigmann J.M., Croy R.G., Bennett R.A. and Wogan G.N. (1982). Metabolic activation of aflatoxin B1: Patterns of DNA adduct formation, removal and excretion in relation to carcinogenesis. Drug Metab. Rev. 13, 581-602.
Fairhurst S., Maxwell S.A., Seawin J.W. and Swanston D.W. (1987). Skin effects of trichothecenes and their amelioration by decontamination. Toxicology. 46, 307-319.
Fink-Gremmels J. and Malekinejad H. (2007). Clinical effects and biochemical mechanisms associated with exposure to the mycoestrogen zearalenone. Anim. Feed Sci. Technol. 137(3), 326-341.
Frisvad J.C. and Samson R.A. (1991). Filamentous fungi in foods and feeds: ecology, spoilage and mycotoxin production. Pp. 31-68 in Handbook of applied mycology: Food and Feeds. D.K. Arora, K.G. Mukerjii and E.H. Marth, Eds. Marcel Dekker, New York.
Gabal M.A., Awad Y.L., Morcos M.B., Barakat A.M. and Malik G. (1986). Fusario toxicoses of farm animals and mycotoxic leucoencephalomalacia of the equine associated with the finding of trichothecenes in feedstuffs. Vet. Hum. Toxicol. 28, 207-212.
Gabarty A. and Abou El Nour S. (2016). Impact of wheat flour infestation by some insects on its quantity and quality loss, fungal contamination and mycotoxins. Int. J. Agric. Biol. 18, 1122-1130.
Galvano F., Piva A., Ritieni A. and Galvano G. (2001). Dietary strategies to counteract the effects of mycotoxins: A review. J. Food Prot. 64, 120-131.
Glahn R.P., Beers K.W., Bottje W.G., Wideman Jr R.F. and Huff W.E. (1991). Aflatoxicosis alters avian renal function, calcium and vitamin D metabolism. J. Toxicol. Environ. Health. 34, 309-321.
Goswami R. and Kistler H.C. (2004). Heading for disaster: Fusarium graminearum on cereal crops. Mol. Plant Pathol. 5, 515-525.
Guengerich F.P. (2001). Forging the links between metabolism and carcinogenesis. Mutat. Res. 488, 195-209.
Guerre P., Burgat V. and Galtier P. (1997). Dose-related increase in liver heme catabolism during rabbit aflatoxicosis. Toxicol. Lett. 92, 101-108.
Guerre P., Eeckhoutte C., Burgat V. and Galtier P. (2000). The effects of T-2 toxin exposure on liver drug metabolizing enzymes in rabbit. Food Addit. Contam. 17, 1019-1026.
Harriet A.M. (2003). Is indoor mold contamination a threat to health? J. Environ. Health. 62, 0022-0892.
Harvey R.B., Kubena L.F., Elissalde M.H., Rottinghaus G.E. and Corrier D.E. (1994). Administration of ochratoxin A and T-2 toxin to growing swine. Am. J. Vet. Res. 55, 1757-1761.
Hayes W.A., Hood R.D. and Lee H.L. (1974). Teratogenic effects of ochratoxin A in mice. Teratology. 9, 93-97.
Hood R.D., Naughton M.J. and Hayes W.A. (1976). Prenatal effects of ochratoxin A in hamsters. Teratology. 13, 11-14.
Huff W.E., Kubena L.F., Harvey R.B. and Doerr J. (1988). Mycotoxin interactions in poultry and swine. J. Anim. Sci. 66, 2351-2355.
Hussain Z., Khan M.Z., Saleemi M.K., Khan A. and Rafique S. (2016). Clinicopathological effects of prolonged intoxication of aflatoxin B1 in broiler chicken. Pakistan Vet. J. 36, 477-481.
Hussein H.S. and Brasel J.M. (2001). Toxicity, metabolism and impact of mycotoxins in humans and animals. Toxicology. 167, 101-134.
Huwig A., Freimund S., Kappeli O. and Dutler H. (2001). Mycotoxin detoxification of animals feed by different adsorbents. Toxicol. Lett. 122, 179-188.
Jacobsen B.J., Coppock R.W. and Mostrom M.S. (2007). Mycotoxins and mycotoxicoses. Extension Bulletin, Montana State University, Bozeman, Montana.
Jan R., Sadique U., Hassan Z.U., Farid K., Ahmad S., Khan S. and Khan H. (2017). Toxico-pathological and reproductive effects of concurrent oral administration of ochratoxin A and endosul-fan in pregnant rabbits (Oryctolagus cuniculus). Pakistan Vet. J. 37, 19-24.
Khan W.A., Khan M.Z., Khan A., Ul Hassan Z. and Saleemi M.K. (2014). Potential for amelioration of aflatoxin B1-induced immunotoxic effects in progeny of White Leghorn breeder hens co-exposed to vitaminE. J. Immunotoxicol. 11, 116-125.
Khatoon A., Khan M.Z., Khan A. and Javed I. (2016). Toxicopathological and serum biochemical alterations induced by ochratoxin a in broiler chicks and their amelioration by locally available bentonite clay. Pakistan J. Agric. Sci. 53, 977-984.
Kolpin D.W., Schenzel J., Meyer M.T., Phillips P.J., Hubbard L.E., Scott T.M. and Bucheli T.D. (2014). Mycotoxins: Diffuse and point source contributions of natural contaminants of emerging concern to streams. Sci. Total Environ. 470, 669-676.
Krishna L., Dawra R.K., Vaid J. and Gupta V.K. (1991). An outbreak of aflatoxicosis in Angora rabbits. Vet. Hum. Toxicol. 32, 159-161.
Kumagai S. (1989). Intestinal absorption and excretion of aflatoxins in rats. Toxicol. Appl. Pharmacol. 97, 88-97.
Kumar M., Dwivedi P., Sharma A.K., Telang A.G., Patil R.D. and Singh N.D. (2008). Immunotoxicity of ochratoxin a and citrinin in New zealand White Rabbits. World Rabbit Sci. 16, 7-12.
Lakkawar A.W., Chattopadhyay S. and Tripurari S.J. (2004). Experimental aflatoxin B1 toxicosis in young rabbits-a clinical and pathoanatomical study. Slovenia Vet. Res. 41, 73-81.
Makkar H.P.S. and Singh B. (2009). Aflatoxicosis in rabbits. J. Appl. Rabbit Res. 14, 218-221.
Manning B.B., Ulloa R.M., Li M.H., Robinson E.H. and Rottinghaus G.E. (2003). Ochratoxin A fed to channel catfish (Ictalurus punctatus) causes reduced growth and lesions of hepatopancreatic tissue. Aquacult. 219, 739-750.
Marin S., Ramos A.J., Cano-Sancho G. and Sanchis V. (2013). Mycotoxins: Occurrence, toxicology, and exposure assessment. Food Chem. Toxicol. 60, 218-237.
Marquardt R.R. and Frohlich A.A. (1992). A review of recent advances in understanding ochratoxicosis. J. Anim. Sci. 70, 3968-3988.
Massey T.E., Stewart R.K., Danniels J.M. and Liu L. (1995). Biochemical and molecular aspects of mammalian susceptibility to aflatoxin B1 carcinogenicity. Proc. Soc. Exp. Biol. Med. 208, 213-227.
Mayura K., Reddy R.V., Hayes A.W. and Berndt W.O. (1982). Embryocidal, fetotoxic and teratogenic effects of ochratoxin A in rats. Toxicology. 25, 175-185.
Mclean M. and Dutton M.F. (1995). Cellular interactions and metabolism of aflatoxin: an update. Pharmacol. Ther. 65, 163-192.
Mezes M. (2008). Mycotoxins and other contaminants in rabbit feed. Pp. 491-506 in Proc. 9th World Rabbit Congr., Verona, Italy.
Mezes M. and Balogh K. (2009). Mycotoxins in Rabbit feed: A review. World Rabbit Sci. 17, 53-62.
Mir M.S. (1998). Studies on pathology and immunology of ochratoxin A induced toxicosis and its interaction with Pasteurella multocida infection in rats. MS Thesis. Veterinary Research Institute, Izatnagar, India.
Mir M.S., Dwivedi P. and Charan K. (1999). Ochratoxin A induced acute toxicity in rabbits. Indian J. Vet. Pathol. 23, 8-13.
Mir M.S. and Dwivedi P. (2000). Clinical studies on experimental subacute ochratoxicosis in rabbits. Indian J. Vet. Pathol. 24, 99-101.
Mir M.S. and Dwivedi P. (2010). Immunopathology of ochratoxicosis-A in New Zealand White Rabbits (Oryctolagus cuniculus). Vet. Scandinavica. 5, 1-10.
Mizutani Y., Ito Y. and Ohtsubo K. (1997). Inhibition of platelet aggregation in vitro by trichothecene mycotoxins. Mycotoxins. 44, 41-44.
Morgavi D. and Riley R.T. (2007). An historical overview of field disease outbreaks known or suspected to be caused by consumption of feeds contaminated with Fusarium toxins. Anim. Feed Sci. Technol. 137(3), 201-212.
Moss M.O. (1996). Mycotoxins: Centenary review. Mycol. Res. 100, 513-523.
Moura M.A., Machado C.H., Porfírio L.C. and Freire R.B. (2004). Effects of ochratoxin A on broiler leukocytes. Br. J. Poult. Sci. 6, 187-190.
Murphy P.A., Hendrich S., Landgren C. and Bryant C.M. (2006). Food mycotoxins: An update. J. Food Sci. 71, 51-65.
Niyo K.A., Richard J.L., Niyo Y. and Tiffany L. (1988). Pathologic, hematologic, and serologic changes in rabbits given T-2 mycotoxin orally and exposed to aerosols of Aspergillus fumigatus conidia. Am. J. Vet. Res. 49, 2151-2160.
Ostry V., Mair F. and Ruprich J. (2013). Producers and important dietary sources of ochratoxin A and citrinin. Toxins. 5, 1574-1586.
Pestka J.J. (2007). Deoxynivalenol: Toxicity, mechanisms and health risks. Anim. Feed Sci. Technol. 137(3), 283-298.
Pfohl-Leszkowicz A. and Manderville R.A. (2007). Ochratoxin A: an overview on toxicity and carcinogenicity in animals and humans. Mol. Nutr. Food Res. 51, 1189-1192.
Placinta C.M., D’Mello J.P.F. and Macdonald A.M.C. (1999). A review of worldwide contamination of cereal grains and animal feed with Fusarium mycotoxins. Anim. Feed Sci. Technol. 78, 21-37.
Ponnuchamy V. (2000). Studies on pathology and immunology of ochratoxin-A induced toxicosis and its interaction with Salmonella typhimurium infection in guinea pigs. MS Thesis. Veterinary Research Institute, Izatnagar, India.
Prabu P.C., Dwivedia P. and Sharma A.K. (2013). Toxicopathological studies on the effects of aflatoxin B1, ochratoxin A and their interaction in New Zealand White Rabbits. Exp. Toxicol. Pathol. 65, 277-286.
Raina J.S. and Singh B. (1991). Prevalence and pathology of mycotoxicosis in poultry in Punjab. Indian J. Animal Sci. 61, 671-676.
Rati E.R., Shantha T. and Ramesh H.P. (1991). Effect of long term feeding and withdrawal of aflatoxin B1 and ochratoxin A on kidney cell transformation in albino rats. Indian J. Exp. Biol. 29, 813-817.
Richard J.L., Thurston J.R., Deyoe B.L. and Booth G.D. (1975). Effect of ochratoxin and aflatoxin on serum proteins, complement activity and antibody production to Brucella abortus in guinea pigs. Appl. Microbiol. 29, 27-29.
Richard L.L., Bray G.A. andRyan D.H. (1991). Mycotoxins as immunomodulatory in animal systems. Pp. 196-220 in Mycotoxins. Cancer and Health. G.A. Bray and D.H. Ryan, Eds. Louisiana State University Press, USA.
Roberts B.A., Glancy E.M. and Patterson D.S.P. (1981). Rapid economical method for determination of aflatoxin and ochratoxin in animal feed stuffs. J. Assoc. Off. Anal. Chem. 64(4), 961-963.
Rotter B.A., Prelusky D.B. and Pestka J.J. (1996). Toxicology of deoxinivalenol (vomitoxin). J. Toxicol. Environ. Health. 48, 1-34.
Sahoo P.K., Chattopadhyay S.K., Johri T.S., Charan K. and Sikdar A. (1993). Pathology of experimental aflatoxicosis in rabbits. Indian J. Anim. Sci. 63, 268-273.
Saleemi M.K., Khan M.Z., Khan A., Hassan Z.U., Khan W.A., Rafique S., Fatima Z. and Sultan A. (2015). Embryotoxic and histopathological investigation of in ovo inoculation of aflatoxigenic fungal extracts in chicken embryos. Pakistan Vet. J. 35, 403-408.
Salem M.H., Kamel K.I., Yousef M.I., Hassan G.A. and El-Nouty F.D. (2001). Protective role of ascorbic acid to enhance semen quality in rabbits treated with sublethal doses of aflatoxin B1. Toxicology. 162, 209-218.
Schatzmayr G. and Streit E. (2013). Global occurrence of mycotoxins in the food and feed chain: facts and figures. World Mycotoxin J. 6, 213-222.
Sekine T., Miyazaki H. and Endou H. (2006). Molecular physiology of renal organic anion transporters. Am. J. Physiol. 290, 251-261.
Sharma P. (1998). Himachal Pradesh rabbit farmers fear toxin in feed: mortality, infertility cases on rise. The Hindustan Times. 210, 1-3.
Singh K.P., Singh R., Singh Y.P., Telang A.G. and Mehrotra M.L. (1999). Investigation of mortality due to aflatoxicosis in New Zealand White Rabbits. Indian J. Vet. Pathol. 23, 83-84.
Stein A.F., Phillips T.D., Kubena L.F. and Harvey R.B. (1985). Renal tubular secretion and reabsorption as factors in ochratoxicosis: effects of probenicid on nephrotoxicity. J. Toxicol. Environ. Health. 16, 593-604.
Stetinova V., Grossmann V. and Kvetina J. (1998). Changes in the gastrointestinal tract, cardiovascular function and some drug metabolizing processes in rats and guinea pigs intoxicated with aflatoxin B1. Polish J. Pharmacol. 50, 135-141.
Still P.E., Macklin A.W., Ribelin W.E. and Smalley E.B. (1971). Relationship of ochratoxin A to fetal death in laboratory and domestic animals. Nature. 31, 563-564.
Streit E., Schatzmayr G., Tassis P., Tzika E., Marin D., Taranu I., Tabuc C., Nicolau A., Aprodu I., Puel O. and Oswald I.P. (2012). Current situation of mycotoxin contamination and co-occurrence in animal feed-focus on Europe. Toxins. 4, 788-809.
Stresser D.M., Bailey G.S. and Williams D.E. (1994). Indole-3-carbinol and â-naphthoflavone induction of aflatoxin B1 metabolism and cytochrome P450 associated with bioactivation and detoxication of aflatoxin B1 in the rats. Drug Metab. Dispos. 22, 383-391.
Sundaram T.K., Chandrasekaran D., Natrajan A. and Mohan B. (1999). Multimycotoxins: An overview of their occurrence in feed ingredients and feeds in Namakkal. Pp. 23-37 in 18th Ann. Conf. Soc. Toxicol., Luchnow. India.
Suzuki S., Kozuka Y., Satoh T. and Yamazaki M. (1975). Studies on the nephrotoxicity of ochratoxin A in rats. Toxicol. Appl. Pharmacol. 34, 479-490.
Sweeney M.J. and Dobson A.D.W. (1998). Mycotoxin production by Aspergillus, Fusarium and Penicillium species. Int. J. Food Microbiol. 43, 141-158.
Szilágyi M., Fekete S., Huszenicza Gy. and Albert M. (1994). Biochemical and physiological effects of long-term sublethal T-2 toxin feeding in rabbits. Acta Biol. Hung. 45, 69-76.
Thacker H.L. and Carlton W.W. (1977). Ochratoxin A mycotoxicosis in the guinea pig. Food Cosmet. Toxicol. 15, 563-574.
Thrasher J.D. (2012). Aflatoxicosis in animals. Aflatoxins and Health. Available at: www.alphaboostjuice.com/aflatoxicosis_in_animals.pdf.
USAID (2012). Aflatoxin: A Synthesis of the Research in Health, Agriculture and Trade. Feed the Future: The Office of Regional Economic Integration USAID East Africa Regional Mission Nairobi, Kenya. Available at: www.eastafrica.usaid.gov/research_in_Health_Agricultureaand_Trade/pdf, 10-15.
Valtchev I., Koynarski T., Sotirov L., Nikolov Y. and Petkov P. (2015). Effect of aflatoxin B1 on moulard duck’s natural immunity. Pakistan Vet. J. 35, 67-70.
Verma R.J. and Mehta D.N. (1998). Occurrence of hemolytic anemia during aflatoxicosis. Indian J. Environ. Toxicol. 8, 5-7.
Vinita R., Prasad L.N. and Sinha B.K. (2003). Pathological and histochemical changes in liver and kidneys in experimental aflatoxicosis in rabbits. Indian J. Vet. Pathol. 27, 57-65.
Voss K.A., Smith G.W. and Haschek W.M. (2007). Fumonisins: Toxicokinetics, mechanism of action and toxicity. Anim. Feed Sci. Technol. 137, 299-325.
Wangikar P.B., Dwivedi P. and Sinha N. (2004b). Effect in rat of simultaneous prenatal exposure to ochratoxin A and aflatoxin B1 I Maternal toxicity and fetal malformations. Birth Defects Res. Part B: Dev. Reprod. Toxicol. 71, 343-351.
Wangikar P.B., Dwivedi P., Sharma A.K. and Sinha N. (2004c). Effect in rat of simultaneous prenatal exposure to ochratoxin A and aflatoxinB1. II. Histopathological features of teratological anomalies induced in fetuses. Birth Defects Res. Part B: Dev. Reprod. Toxicol. 71, 352-358.
Wangikar P.B., Dwivedi P., Sinhab N., Sharmaa A.K. and Telanga A.G. (2005). Teratogenic effects in rabbits of simultaneous exposure to ochratoxin A and aflatoxin B1 with special reference to microscopic effects. Toxicology. 215, 37-47.
WHO-World Health Organization International Agency for Research on Cancer. (1993). Toxins derived from Fusarium moniliforme: Fumonisins B1 and B2 and fusarin C. World Health Organisation. Available at: https://www.ncbi.nlm.nih.gov/books/NBK513589.
WHO-World Health Organization International Agency for Research on Cancer. (2000). Hazardous chemicals in humans and environmental health: International programme on chemical safety, Geneva, Switzerland. World Health Organisation. Available at: https://apps.who.int/iris/handle/10665/66161.
Wu F. (2004). Mycotoxins risk assessment for the purpose of setting international regulatory standards. Environ. Sci. Technol. 38, 4049-4055.
Wu F. (2006). Economic impact of fumonisin and aflatoxin regulations on global corn and peanut markets. Pp. 277-289 in The Mycotoxin Factbook. Food and Feed Topics. D. Barug, D. Bhatnager, H.P. van Egmond, J.W. van der Kamp, W.A. van Osenbruggen and A. Visconti, Eds. Wageningen Academic Publishers, Wageningen, The Netherlands.
Zaki M.M., El-Midany S.A., Shaheen H. M and Rizzo L. (2012). Mycotoxins in animals: Occurrence, effects, prevention and management. J. Toxicol. Environ. Health Sci. 4, 13-28.
Zofair S.M., Mathew S. and Verma R.J. (1996). Ochratoxin induced hemolysis in rabbits. Indian. J. Exp. Biol. 34, 592-593.
