An Investigation on Population Structure and Inbreeding of Sangsari Sheep
محورهای موضوعی : Camel
م. میرزایی ایلالی
1
(Department of Animal and Poultry Breeding and Genetics, Faculty of Animal Science, Gorgan University of Agricultural Science and Natural Resources, Gorgan, Iran)
س. حسنی
2
(دانشگاه علوم کشاورزی و منابع طبیعی گرگان)
م. آهنی آذری
3
(Department of Animal and Poultry Breeding and Genetics, Faculty of Animal Science, Gorgan University of Agricultural Science and Natural Resources, Gorgan, Iran)
ر. عبداله‌پور
4
(Department of Animal Science, Islamic Azad University, Qaemshahr Branch, Qaemshahr, Iran)
س. نقویان
5
(Department of Animal and Poultry Breeding and Genetics, Faculty of Animal Science, Gorgan University of Agricultural Science and Natural Resources, Gorgan, Iran)
کلید واژه: genetic diversity, inbreeding, population structure, Sangsari sheep,
چکیده مقاله :
The aim of this study was to describe inbreeding and population structure in Sangsari sheep breeding station. For this reason, data from 7028 Sangsari sheep which were collected during 1987-2014 in Sangsari sheep breeding station located near to Damghan city, Semnan province were used. Lambs born during 2010-2014 were considered as reference population. The genetic structure analysis of the population was realized by the ENDOG (v.4.8) software. Mean inbreeding of total population and reference population was 0.28% and 0.70%, respectively. Average relatedness, realized effective population size based on individual increase in inbreeding, effective numbers of founders (fe),and founder genome equivalents (fg) were estimated 0.59%, 148.75, 140 and 49.97, respectively. Mean generation interval in present population was 4.24 years and average number of equivalent to discrete generations was estimated as 1.64. Average coancestry, effective number of ancestors (fa) and average equivalent complete generation were calculated 1.0005%, 76 and 3.02, respectively. Ratio of fe/fa which expresses the effect of population bottlenecks was 1.84. 50% of total genetic variation was explained by the 32 most influential ancestors. By monitoring parameters associated with genetic diversity and breeding management, the reduction of genetic diversity and probable harmful effects resulting from excessive increase of inbreeding can be prevented.
هدف این مطالعه توصیف همخونی و ساختار جامعه در ایستگاه اصلاح نژاد گوسفند سنگسری بود. به این منظور، دادههای 7028 رأس گوسفند سنگسری که در طول سالهای 1365 تا 1392 در ایستگاه اصلاح نژاد گوسفند سنگسری واقع در نزدیکی شهر دامغان، استان سمنان جمع‌آوری شده بود، مورد استفاده قرار گرفت. بره‌های متولد شده در سالهای 1388 تا 1392 به عنوان جامعه مرجع درنظر گرفته شدند. آنالیز ساختار ژنتیکی این جامعه با نرم افزار ENDOG نسخه 8/4 انجام شد. میانگین همخونی کل جامعه و جامعه مرجع به ترتیب 28/0 و 70/0 درصد بود. متوسط رابطه خویشاوندی، اندازه جامعه مؤثر تحقق یافته بر اساس افزایش انفرادی در همخونی، تعداد مؤثر بنیان گذاران (fe) و معادل ژنومی حیوانات بنیان‌گذار (fg) به ترتیب 59/0 درصد، 75/148، 140 و 97/49 تخمین زده شد. میانگین فاصله نسلی در جامعه حاضر 24/4 سال و متوسط تعداد نسل های معادل 64/1 تخمین زده شد. متوسط همتباری، تعداد مؤثر اجداد (fa)، متوسط نسل معادل کامل به ترتیب 0005/1 درصد، 76 و 02/3 محاسبه شد. نسبت fe به fa که بیان کننده اثر باتل نک‌های جامعه است، 84/1 بود. پنجاه درصد کل تنوع ژنتیکی مربوط به 32 جد با بالاترین نفوذ بود. با نظارت برپارامترهای مربوط به تنوع ژنتیکی و مدیریت جفتگیری می‌توان از کاهش تنوع ژنتیکی و اثرات مضر احتمالی ناشی از افزایش همخونی جلوگیری نمود.
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