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  • Evaluation of Antimicrobial Activity of Hydroalcoholic Extracts from Different Parts of Ferula assafoetida L. in Three Regions of South Khorasan Province

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کد مقاله : JCHR-2108-1397 (R1) بازدید : 366 صفحه: 621 - 634

10.22034/jchr.2022.1938969.1397

نوع مقاله: پژوهشی

Evaluation of Antimicrobial Activity of Hydroalcoholic Extracts from Different Parts of Ferula assafoetida L. in Three Regions of South Khorasan Province

محورهای موضوعی :

Batool Jalili 1 , Sakineh Saeidi-sar 2 , Nahid Masoudian 3 , Asghar Zarban 4 , Mohammad Hasan Namaei 5

1 - Department of Biology, Damghan Branch, Islamic Azad University, Damghan, Iran
2 - Department of Agriculture, Faculty of Shariati, Tehran Branch, Technical and Vocational University (TVU), Tehran, Iran
3 - Department of Biology, Damghan Branch, Islamic Azad University, Damghan, Iran
4 - Professor, Department of Biochemistry, Faculty of Medicine, Birjand University of Medical Sciences, Birjand, Iran
5 - Infectious Disease Research Center, Birjand University of Medical Sciences, Birjand, Iran

تاریخ دریافت : 1400/06/06 تاریخ پذیرش : 1401/01/28 تاریخ انتشار : 1401/09/10

کلید واژه: hydroalcoholic extract, Antimicrobial Activity, South Khorasan Province, Ferula asafoetida L,

چکیده مقاله :

Due to the increased resistance of bacteria to chemical drugs and the low side effects of medicinal plants, using these plants has been considered in disease treatment. Ferula asafoetida L., as one of the medicinal and native plants of southern Khorasan province (Iran), is used in traditional medicine to treat many diseases. The present study aimed to investigate the antimicrobial activity of hydroalcoholic extract of different parts of Ferula asafoetida L. in three regions of South Khorasan Province.The required chemicals were purchased from Merck and Sigma companies. The microbes were obtained from the Birjand University of Medical Sciences and the Iranian Scientific and Industrial Research Organization. The antimicrobial activity of hydroalcoholic extracts was evaluated by dilution in agar. For this purpose, the plant was collected from three areas: Sarbisheh, Ghayen, and Nehbandan. After identification, drying, and pulverizing, the extracts were prepared by soaking. Some of the extracts showed an inhibitory effect on gram-positive bacteria (Staphylococcus aureus and Bacillus subtilis), but none inhibited the growth of Gram-negative bacteria. Moreover, hydroalcoholic extracts of different parts of Ferula asafoetida L. of Sarbisheh had no inhibition effect on the growth of Candida albicans. The results revealed that the hydroalcoholic extracts of the plant could be used as a suitable substitute for chemical drugs to treat diseases.

چکیده انگلیسی:

منابع و مأخذ:


  1. Mitschel P.A., Lea R.B., Bathala M.S., 1972. Antimicrobial agens from Higher Plants. I, Introduction, National and methodology Lioydia.157 - 66.
    2.
  2. Khosravi A., Malecan M.,2004. Effects of Lavandul astoechas extracts on staphylococcus aureus and other gram negative bacteria.The Journal of Qazvin University of Medical Sciences. 29, 3-9. [In Persian]
    3.
  3. Hancock E.W., 2005. Mechanisms of action of newer antibiotics for Gram-positive pathogens. Lancet Infect Dis. 5, 209–218
    4.
  4. Davies J., Webb V., Kraause R.M., 1998. The Emergining Infections.San Diego: Academic press.239-273
    5.
  5. Yadegary D., 2002. Biological activities of essential oil of peppermint and Myrtus communis, Martyr Beheshti University of Medical Sciences. Summary of Congress articles of Iranian Medicinal Plants. pp.64 [In Persian]
    6.
  6. pimenov M.G., leonov M.V., 2004. The Asian Umbelliferae Biodiversity Database (ASIUM) with Particular Reference to South-West Asian Taxa. Turkish Journal of Botany. 28,139-145.
    7.
  7. 7. Lamnaouer D., Omari M., Mounir A.EL., Alouani M., 1990. Anticoagulant actitivity of ferula Communis in sheep maghre 6-veterinaire. 5(21),5-10.
    8.
  8. 8. Zargari A. Medicinal Plants, 4th ed.Tehran Univ ,2002.
    9.
  9. 9. Omidbaigi R. Production and processing of medicinal plants, 2th ed. Astan ghods ,2009.
    10.
  10. 10. Moradi H., Planet V., RuhElahi Keshtoli N., Khosravi N., Study of medicinal properties of Ferula assa-foetida, the first national conference on sustainable development in agricultural sciences and natural resources with the environment Environmental culture,Tehran. https://civilica.com/doc/783472/
    11.
  11. Zare Karizi A.R., Omidi M., Fallah Hosseini H., Yazdani D., Rezazadeh S., Irvani N., Oladzad A., 2011. A review of the harmacological effects of the medicinal plant (Ferula assa - foetida L.). J Med plants. 10(40),17-25.(Persian)
    12.
  12. Mirdavoodi Akhavan H., Babakhanlo P., 2008. Identification of Medicinal Plants in Markazi Province. Iranian Journal of Medicinal and Aromatic Plants. 4(38),544-559.
    13.
  13. 13. Vaishnavi C., Kaur S., Kaur M., 2007. Bactericidal activity of kitchen spices and condiments on entero pathogens.Natural Product Radiance .6(1), 46-9.
    14.
  14. Sasikumar J.M., Thayumanavan T., Subashkumar R., Janardhanan K., Lakshmanaperumalsamy P., 2007. Antibacterial activity of some ethnomedicinal plants from the Nilgiris, Tamil Nadu, India. Nat Prod Radiance. 6(1), 34-39.
    15.
  15. Martinez M.J., Betancourt J., Alonso-Gonzalez N., Jauregui A., 1996. Screening of some cuban medicinal plants for antimicrobial activity. J Ethnopharmacol . 52(3), 171-174.
    16.
  16. Mortazavi S.A., Tabatabai Yazdi F., Alizadeh Behbahani B., Vasiee A.R., 2015. Antibacterial effect of Ferula assa-foetida (on some pathogenic diseases of food origin), the third Conference food science and industry, Date: 2015/9/9
    17.











17. Naeini A., Naseri M., Kamalinejad M., Khoshzaban F., Rajabian T., Nami H., Mansori S., Zavieh D., 2011. Study On Anti_Candida Effects Of Essential Oil And Extracts of Iranian Medicinal Plants, In Vitro. Journal of Medicinal Plants. 10(38), 163 -172.
 


  1. Vahedi A., Vahedi A., Dehpouri F., 2013. Study of chemical compounds and essential oils and antimicrobial activity of Ferula assa species, 3rd National Conference on Medicinal Plants, Amol. https://civilica.com/doc/288176
    2.
  2. Rahmoun M.N., Benabdallah M., Villemin D., Boucherit K., Mostefa Kara B., Ziani Cherif C., 2010. Antimicrobial screening of the Algerian lawsonia inermis, (henna). Der Pharma Chemica. 2(6) ,320 -326.
    3.
  3. Cock I.E., 2008. Antibacterial Activity of Selected Australian Native Plant Extracts.The Internet Journal of Microbiology. 4(2), 1–8.
    4.
  4. Joshi B., Lekhak S., Shorma A., 2009. Antibacterial Property of Different Medicinal Plants: Ocimum sanctum, Cinnamomum zeylanicum, Xanthoxylum armatum and Origanum majorana. Nepal Journals Onliney. 5(1),143–150.
    5.
  5. Walter C., Shinvari Z.K., Afzal I., Malik R.N., 2011. Antibacterial Activity in Herbal Products Used in Pakistan. Pakistan Journal Of Botany. 43,155–162.
    6.
  6. Amiri A., Jomehpour N., 2016. Evaluation the Effect of Anti bacterial of Ferula assa-foetida L, Carum copticum, Mentha piperita L Hydroalcoholic Extract on Standard Sensitive and Methicillin- Resistant Staphylococcus aureus , Escherichia coli O157H7 and Salmonella typhimurium. Sjimu. 24(2),72-79.
    7.
  7. Shakouri S., Motevolizadeh A., Dilem Salehi M., 2015. Evaluation of chemical compounds, antimicrobial properties, antioxidant activity of essential oil and plant extract of Ferula assafoetida L. In Neyshabur, 23rd National Congress of Science and Technology of Iranian Food, Islamic Azad University, Quchan Branch. [In Persian]
    8.
  8. Dehpour Jouybari A.A., 2013 .Identification of the Compounds of Essential Oils and Antimicrobial Activity of Ethanolic Extractof Ferula assafoetida L. Journal of Application Biotechnology and Microbiology. 33-40. [In Persian]
    9.
  9. Unasho A., Melaku A., Debela A., Mekasha A., Girma S., Kebede T., Fantaw S., Asaminew N., 2009. Investigation of antibacterial activities of Albizia gummifera and Ferula communis on Streptococcus pneumoniae and Streptoccus pyogenes. Ethiop Med J. 47, 25-32.
    10.
  10. Akhlaghi Feizabad S.H., 2014. Evaluation of Antioxidant Activity of Ferula ovina Methanol Extract Essential Oil Analysis by GC-MS and Determination of Antibacterial Effect of Flower Stem and Leaf. Essential Oil Journal of Quantum Chemistry and Spectroscopy 23-35.[In Persian]
    11.
  11. Priscila G., Alzira M.S., Thereza C.V., 2006. Chemical resistance of the gram negative bacteria todifferent sanitizers in a water purification system.BMC Infectious Disease. 6,131.
    12.
  12. Hesani B.,Identification of essential oil components and evaluation of antioxidant, anticancer and antimicrobial effects of Ferula ovina Boiss from Kashan region . Masters Testis , Kashan University,2012.
    13.
  13. Tamemoto K., Takaishi Y., Chen B., Kawazoe K., Shibata H., Higuti T., 2001.Sesquiterpenoids from the fruits of Ferula kuhistanica and antibacterial activity of the constituents of F. kuhistanica. Phytochemistry. 58(5),763-767.
    14.
  14. Marilena C., Bersani C., Comi, G., 2001. Impedance measurements to study the antimicrobial activity of essential oils from Lamiaceae and Compositae. International Journal of Food Microbiology. 67,187–195.
    15.
  15. Bajpai V.K., Al-Reza S.M., Choi U.K., Lee J.H., Kang S.C., 2009. Chemical composition antibacterial and antioxidant activities of leaf essential oil and extracts of Metasequioa glyptostroboides Miki ex Hu. Food Chem Toxicol .47,1876-83.
    16.
  16. Weerakkody N.S., Caffin N., Turner M.S., Dykes G.A., 2010. In vitro antimicrobial activity of less-utilized spice and herb extracts against selected food-borne bacteria. Food Control. 21,1408-1414.
    17.
  17. 34. Krittika N., Natta L., Orapin K., Antimicrobial effect of five Zingiberaceae Essential oils.Molecules.12, 2047-2060.
    18.
  18. Elgayyar M., Draughon F.A., Golden D.A., 2001. Antimicrobiol activity of essential oils from plants against selected pathogenic and saprophytic microorganisms. J Food Protect .64,1019-1024.
    19.
  19. Duffy C.F., Power RF., 2001. Antioxidant and antimicrobial properties of some Chinese plant extracts. Int J Antimicrob Ag.17, 527-529.
    20.
  20. Opperman T.J., Nguyen S.T., 2015. Recent advances toward a molecular mechanism of efflux pump inhibition. Front. Microbiol. 6,421.
    21.
  21. Venter H., Mowla, R., Ohene-Agyei T., Ma S., 2015. RND-type drug eux pumps from Gram-negative bacteria: molecular mechanism and inhibition. Front. Microbiol. 6, 377.
    22.
  22. Tegos G., Stermitz F.R., Lomovskaya O., Lewis K., 2002. Multidrug pump inhibitors uncover remarkable activity of plant antimicrobials. Antimicrob Agents Chemother.46,3133–3141.
    23.
  23. Habibi Z., Ghanian S., Ghasemi S., Yousefi M., 2013. Chemical composition and antibacterial activity of the volatile oil from seeds of Artemisia annua L.from Iran. NatProd Res.27,198-200.
    24.
  24. Kahkonen M.P., Hopia A.I., Vuorela H.J., Rauha J.P., Pihlaja K., Kujala T.S., 1999. Antioxidant Activity of Plant Extracts Containing Phenolic Compounds. J Agric Food Chem. 47(10), 3954-3962.
    25.
  25. Yalpani M., Tyman J.U.P., 1983. The phenolic acids of Pistachia vera.Phytochemistry.22,2263-2266.
    26.
  26. Marner F.J., Freyer A., Lex J., 1991.Triterpenoids from gum mastic: The resin of Pistacia lentiscus. Phytochemistry. 30, 3709-3721.
    27.
  27. Yadav R.N.S., Agarwala M., 2011. Phytochemical analysis of some medicinal plants. J Phytology. 3(12),10-14.
    28.
  28. Zakerin A.R., Ahmadi E., Fasihi Ramandi M., Abdollahi S., Molazadeh A.R., Jafari S., 2015. The Effects of Ecologic Condition on Antimicrobial Activity of Endemic Herbal Extracts in Fars Province. JFUMS. 5(1),111-119. [In Persian]
    29.
  29. Zhang Z., Liao L., Moore J., Wu T., Wang Z., 2009 .Antioxidant phenolic compounds from walnut kernels (Juglans regia L.). Food Chem .113(1), 160-165.
    30.
  30. 47. Taguri T., Tanaka T., Kouno I., 2006. Antibacterial spectrum of plant polyphenols and extracts depending upon hydroxyl phenyl structure. Biol. Pharm. Bull. 29, 2226–2235.
    31.
  31. Tian F., Li B., Ji B., Zhang G., Luo Y., 2009. Identification and structure–activity Relationship of gallotannins separated from Galla chinensis. LWT-Food Sci. Technol. 42,1289–1295.
    32.
  32. 49. Negi P.S., Review Plant extracts for the control of bacterial growth: Efficacy, stability and safety issues for food application. Int J Food Microb.156(1),7-17
    33.
  33. 50. Da Silva L.C.N., Sandes J. M., de Paiva M.M., de Araújo J.M., Figueiredo R.C.B.Q.D., da Silva M.V., 2013. Anti- Staphylococcus aureus action of three Caatinga fruits evaluated by electron microscopy. Nat. Prod. Res. 27, 1492–1496.
    34.
  34. 51. Hayek S.A., Gyawali R., Ibrahim S.A., 2013. “Antimicrobial natural products” in Microbial Pathogens and Strategies for
    35.

Combating them: Science, Technology and Education, FORMATEX, 910–921.

52 .Gyawali R., Ibrahim S.A., 2014. Natural products as antimicrobial agents. Food Control. 46, 412–429.

  1. 53. Nostro A., Germano M.P., Angelo V.A., Marino A., Connatelli M.A., 2000 .Extraction methods and bioautography for evaluation of medicinal plant antimicrobial activity. Lett. Appl. Microbiol. 30(5), 389-394.
    2.
  2. 54. Salehi M., Hashemi Karuie S.M., Nasrolahi Omran A., Mobini M., Asghar Hedari M., 2015. Antifungal activity of in vitro aqueous and alcoholic extracts of Barije root (Ferula gummosa). Journal of Birjand University of Medical Sciences. 21(4), 444-450.
    3.

55.Bashir S., Alam M., Ahmad B., Aman A., 2014 .Antibacterial, Anti-fungal and Phytotoxic activities of Ferula narthex Boiss.Pak J Pharm Sci .27(6),1819-1825.

  1. 56. Naeini A., Khosarvi A.R., Chitsaz M., Shokri H., Kamlnejad M., 2009. Anti-Candida albicans activity of some Iranian plants used in traditional medicine.19(3),168-172.
    2.
  2. 57. Jafari A., Jafari H., Deghanbanadkoki A., Baghbanian M., 2014 .Antifungal Activity of Aqueous Extracts from Ferula assa foetida Aerial parts on Candida albicans and its Comparison with Fluconazole in vitro.TB.13 (3),171-181.
    3.
  3. 58. Mohammadi R., Shokouh Amiri M.R., Sepah vand A., Roodbar Mohammadi S., Shadzi S., Mirsafaei H.j., 2009. Antifungal Activity of Ferula assa- foetida Against Clinical Agents of Mucormycosis. Journal of Isfahan Medical School . 27(100),581-88.
    4.
  4. 59. Chevallier A., 1996. Encyclopedia of Herbal Medicine.1sted. New York: DK Publishing Inc. Ferula gummosa.pp. 259.
    5.

60.Srivastava A.W., Shym S., 2002. Citrus: Climate and soil.Edition 1st. Delhy, India: International Book Distributing Company. pp.151-153

61  .Mahmoodi H., Rahnama K., Arabkhani M., 2011. evaluation of antibacterial activity of essential oil and hydro extract of herbal plants on Bacteria. JMP. 9(4),34-45. [In Persian]

  1. 62. Naderi Hagibaghercandi M., Sefidkon F., Azizi A., 2012. Affect of various methods of distillation on quantity and quality of Lauris nobilis essential oil. JMP. 38(1),78-84. [In Persian]
    2.
  2. 63. Haji Mehdi Poor H., Khanavi M., Shekarchi M., Abedi Z., Pir Ali Hamedani M., 2010. Evaluation and defining of best methods to extract phenol compounds in plants. JMP. 4(32),145-152. [In Persian]
    3.
  3. 64. Ayim J.S., Dwuma Badu D., Fiagbe NY., 1977. Constituents of West African medicinal plants.XXI. Tiliafunimine,a new imino bisbenzylisoquinoline alkaloid fromTiliacora funifera.LIoydia. 40,561-565.
    4.

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