اثر تمرین صبح در مقایسه با تمرین عصر بر پاسخ اسپکسین و لپتین به هشت هفته تمرین استقامتی در زنان چاق
محورهای موضوعی :
فصلنامه زیست شناسی جانوری
محمد کریمی
1
,
مژگان بقایی برزآبادی
2
1 - گروه تربیت بدنی و علوم ورزشی، دانشگاه صنعتی قم، قم، ایران
2 - گروه تربیت بدنی و علوم ورزشی، دانشگاه صنعتی قم، قم، ایران
تاریخ دریافت : 1402/02/17
تاریخ پذیرش : 1402/03/12
تاریخ انتشار : 1402/09/01
کلید واژه:
چاقی,
تمرین استقامتی,
اشتها,
ریتم شبانهروزی,
چکیده مقاله :
اختلال در تنظیم تعادل انرژی در شرایط چاقی دربرگیرنده مکانیسمهای متعددی است که بسیاری از آنها هنوز به درستی شناخته شده نیستند. ریتمهای شبانهروزی، نوسانات هورمونی و به ویژه هورمونهای درگیر در بحث اشتها را به دنبال دارند. هدف از این تحقیق مطالعه اثر هشت هفته تمرین استقامتی در نوبت صبح در مقایسه با نوبت عصر بر مقادیر اسپکسین و لپتین زنان چاق بود. در این مطالعه نیمه تجربی 30 زن داوطلب چاق با میانگین سنی 4/4 ± 3/35 سال و نمایه توده بدنی 2/1 ± 7/31 کیلوگرم/مترمربع به طور تصادفی در سه گروه مساوی (10 = n) شامل گروههای کنترل، تمرین صبح و تمرین عصر تقسیم شدند. پروتکل تمرین استقامتی شامل به مدت هشت هفته، سه جلسه در هفته و با شدت 60 تا 75 درصد ضربان قلب بیشینه اجرا گردید. 48 ساعت قبل و پس از مداخله تمرین استقامتی، در شرایط 10 ساعت ناشتایی شبانه، خونگیری انجام شد. مقادیر اسپکسین و لپتین به روش الایزا ارزیابی شد. تجزیه و تحلیل داده ها با استفاده از آزمون تحلیل واریانس یکطرفه انجام شد. نتایج نشان داد مداخله تمرین در صبح و عصر منجر به کاهش معنادار در مقادیر لپتین (02/0 = p) و افزایش معنادار در مقادیر اسپکسین (03/0 = p) گردید. در مقایسه بین تمرین صبح و عصر، تغییرات لپتین (01/0 =p ) و اسپکسین (01/0=p ) در نوبت عصر بیشتر بود. بر اساس یافته های این مطالعه به نظر میرسد تمرینات استقامتی با شدت متوسط در یک دوره هشت هفتهای میتواند اثرات مثبتی بر هورمونهای اسپکسین و لپتین در موضوع اشتها داشته باشد. تمرینات عصر نسبت به تمرینات صبح اثرات بهتری به دنبال دارد.
چکیده انگلیسی:
Disturbance in regulation of energy balance in obesity involves several mechanisms, many of which are still not well understood. Circadian rhythms are followed by hormonal fluctuations, especially hormones involved in appetite. The aim of this research was to study the effect of eight weeks of endurance training in the morning compared to the evening on the levels of spexin and leptin in obese women. In this semi-experimental study, 30 obese female volunteers with an average age of 35.3 ± 4.4 years and a body mass index of 31.7 ± 1.2 kg/m2 were randomly divided into three equal groups (n = 10) including; Control, morning training and evening training groups. The protocol of endurance training was carried out for eight weeks, three sessions per week and with an intensity of 60 to 75% of the maximum heart rate. 48 hours before and after the intervention of endurance training, blood sampling was done under conditions of 10 hours of overnight fasting. Spexin and leptin values were evaluated by ELISA method. Data were analyzed by using one-way analysis of variance test at a significance level of p<0.05. The results showed that exercise intervention in the morning and evening led to a significant decrease in leptin values (p=0.02) and a significant increase in spexin values (p=0.03). In comparison between morning and evening training, changes in leptin (p=0.01) and spexin (p=0.01) were higher in the evening session. Based on the findings of this study, it seems that endurance training with moderate intensity in a period of eight-week may have positive effects on the hormones of spexin and leptin in the matter of appetite. Evening training has better effects than morning training.
منابع و مأخذ:
Adams K.F., Schatzkin A., Harris T.B., Kipnis V., Mouw T., Ballard-Barbash R. and et al. 2006. Overweight, obesity and mortality in a large prospective cohort of persons 50 to 71 years old. New England Journal of Medicine, 355(8):763-778.
Christoffersen B.Ø., Sanchez-Delgado G., John L.M., Ryan D.H., Raun K., Ravussin E. 2022. Beyond appetite regulation: Targeting energy expenditure, fat oxidation, and lean mass preservation for sustainable weight loss. Obesity, 30(4):841-857.
Dibner C., Schibler U., and Albrecht U. 2010. The mammalian circadian timing system: organization and coordination of central and peripheral clocks. Annual Review of Physiology, 72:517-549.
Flegal K.M., Carroll M.D., Ogden C.L., Lester R.C. 2010. Prevalence of Overweight and Obesity in the United States, 1999-2004. JAMA, 303(3):235-241.
Ge J.F., Walewski J.L., Anglade D., Berk P.D. 2016. Regulation of hepatocellular fatty acid uptake in mouse models of fatty liver disease with and without functional leptin signaling: Roles of NfKB and SREBP-1C and the effects of spexin. Seminars in Liver Disease, 36(4):360-72
Gu L., Ma Y., Gu M., Zhang Y., Yan S., Li N. and et al. 2015. Spexin peptide is expressed in human endocrine and epithelial tissues and reduced after glucose load in type 2 diabetes. Peptides, 71:232-239
Karimi M., Safapoor F. 2018. Effect of a period of selected yoga exercises on serum levels of serotonin and dopamine in non-athlete obese women. Journal of Practical Studies of Biosciences in Sport, 6(11):70-80.
Khadir A., Kavalakatt S., Madhu D. and et al. 2020. Spexin as an indicator of beneficial effects of exercise in human obesity and diabetes. Scientific Reports, 10:10635.
9. Kumar S., Hossain J., Nader N., Aguirre R., Sriram S., Balagopal P.B. 2016. Decreased circulating levels of spexin in obese children. Journal of Clinical Endocrinology and Metabolism, 101(7): 2931-2936.
Lambert C.P., Sullivan D.H., Evans W.J. 2003. Effects of testosterone replacement and/or resistance training on interleukin-6, tumor necrosis factor alpha, and leptin in elderly men ingesting megestrol acetate: A Randomized Controlled Trial. The Journals of Gerontology, 58(2):165-170.
Lichtenstein M.B., Andries A., Hansen S., Frystyk J., Stoving R.K. 2015. Exercise addiction in men is associated with lower fat-adjusted leptin levels. Clinical Journal of Sport Medicine, 25(2):138-43
Ma A., He M., Bai J., Wong MKH., Ko WKW., Wong AOL. 2017. Dual role of insulin in spexin regulation: functional link between food intake and spexin expression in a fish model. Endocrinology, 158:560-577.
Parastesh M, Heidarianpour A, Saremi A. 2014. The effect of 12 weeks of aerobic training on lung function and serum leptin levels in obese men. Journal of Ilam University of Medical Sciences, 22(1):139-146
Radic R., Nikolic V., Karner I., Kosovic P., Kurbel S., Selthofer R., Curkovic M. 2003. Circadian Rhythm of Blood Leptin Level in Obese and Non-Obese People. Collegium Antropologicum, 27(2): 555-561.
Radziuk J.M. 2013. The Suprachiasmatic Nucleus, Circadian Clocks, and the Liver. Diabetes, 62:1017-1019.
Rahmani Nia F., Hojjati Z., Rahnama N., Soltani B. 2009. Leptin [Heart Disease and Exercise]. World Journal of Sport, 13-20 (Persian).
Shahidi F., Pirhadi S. 2014. The effect of physical exercise and training on serum leptin levels. Razi Journal of Medical Sciences, 21(1246):1-14.
Walewski JL., Ge F., Gagner M., Inabnet W.B., Pomp A., Branch A.D. and et al. 2010. Adipocyte accumulation of long-chain fatty acids in obesity is multifactorial, resulting from increased fatty acid uptake and decreased activity of genes involved in fat utilization. Obesity Surgery, 20(1):93-107.
Walewski J.L., Ge F., Lobdell H.T., Levin N., Schwartz G.J., Vasselli J.R. 2014. Spexin is a novel human peptide that reduces adipocyte uptake of long chain fatty acids and causes weight loss in rodents with diet-induced obesity. Obesity (Silver Spring), 22(7):1643-52.
Weltman A., Pritzlaff C., Wideman L., Considine R., Fryburg D., Gutgesell M. and et al. 2000. Intensity of acute exercise does not affect serum leptin concentrations in young men. Medicine and Science in Sports and Exercise, 32(9):1556.
Wong M.K., Sze K.H., Chen T., Cho C.K., Law H.C., Chu I.K. and et al. 2013. Goldfish spexin: solution structure and novel function as a satiety factor in feeding control. American Journal of Physiology, Endocrinology and Metabolism, 305(3):348-66
Wu H., Lin F., Chen H. and et al. 2016. Ya-fish (Schizothorax prenanti) spexin: identification, tissue distribution and mRNA expression responses to periprandial and fasting. Fish Physiol. Biochemistry, 42:39.
Yang I., Coldiz G.A. 2015. Prevalence of Overweight and Obesity in the United States, 2007-2012. JAMA Internal Medicine, 175(8):1412-1413.
Zilaei-Bouri S.H., Khedri A., Ahangar pour A., Zilaei-Bouri M. 2013. Comparing the Effects of Aerobic Exercises of High and Moderate Intensity on Serum Leptin Levels and Capacity of Fat Oxidation among Young Obese Girls. Journal of Fasa University of Medical Sciences, 3(1):81-87.
Zoladz J., Konturek S., Duda K., Majerczak J., Sliwowski Z., Grandys M., Bielanski W. 2005. effect of moderate incremental exercise, performed. Journal of Physiology and Pharmacology, 56(1):63-85.
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